research Breaking the ‘rule-of-five’ to access bridged bicyclic heteroaromatic bioisosteres
A new method creates unique chemical structures that could improve drug discovery.
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300-330 / 1000+ results research A computer‐aided drug repurposing: the antibacterial agents targeting GroEL
Daprodustat, combined with PAβN, could be a new antibacterial treatment.
research Small molecules facilitate single factor-mediated sweat gland cell reprogramming
Small molecules can help turn skin cells into sweat gland-like cells for potential skin repair.
research Evaluation of total sulfhydryl levels and dietary habits in pemphigus vulgaris
Eating foods with sulfhydryl may worsen pemphigus vulgaris.
research Trans glutaminase-mediated cross-linking in mammalian epidermis
research De novo designed bifunctional proteins for targeted protein degradation
Newly designed proteins can effectively degrade specific proteins in cells, offering a promising alternative for targeted protein degradation.
research Role of cholesterol sulfate in epidermal structure and function: Lessons from X-linked ichthyosis
Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.
research Cross-linked features of mouse pelage hair resistant to detergent extraction
Some mutant mice have hair with abnormal cross-linking, mainly in the cuticle, not affecting other hair parts.
research A mechanical model of overnight hair curling
Longer time setting curls overnight leads to better curl retention.
research 566 Staphylococcus epidermidis for the topical treatment of epidermal growth factor receptor (EGFR) inhibitor-induced dermal toxicity
ATR04-484 ointment shows promise for treating skin issues from cancer therapies.
research A new staining method for visualization of keratin filaments in hair fibre cross sections.
A new method effectively visualizes keratin in hair without harsh chemicals.
research Serine-rich ultra high sulfur protein gene expression in murine hair and skin during the hair cycle.
Two specific genes are more active during hair growth in mice.
research De novo designed bifunctional proteins for targeted protein degradation
Newly designed proteins can effectively degrade specific proteins in cells, offering a potential new therapy method.
research New Insight Into the Immunostaining Method Suitable for the Pilosebaceous Complex Unit
The study found that a one-step antibody method is better than the LSAB method for accurately studying hair follicle structures without false positives.
research 1422 Uncoupling desmosomal cadherin adhesion activates quiescent hair follicle stem cells and orchestrates self-organized regeneration through outside-in signaling
Disrupting a specific protein's function in hair follicle stem cells triggers their activation and a self-healing process.
research Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia
Oxidative stress affects hair loss in men with androgenetic alopecia.
research Hair colouring, permanent styling and hair structure
Frequent hair coloring and styling can damage hair and cause breakage or loss.
research Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts
Minoxidil reduces lysine hydroxylase in skin cells.
research Lack of a gonadal or adrenal androgenic mechanism for the hypertrichosis produced by diazoxide, phenytoin and minoxidil
These drugs cause hair growth without affecting testosterone or adrenal hormones.
research Perspectives and Challenges of Hair Analysis
Hair is a complex organ, and understanding its detailed structure and growth phases is crucial for analyzing substances within it.
research Study of the composition of 140 shampoos: similarities and differences depending on the sales channel used
Pharmacy-sold shampoos tend to have fewer allergens compared to those sold in other stores.
research A Hair Growth-Enhancing Component of Hydrolysate of Human Placenta: In vitro and In vivo Assessments
IGF-1 from human placenta helps hair grow.
research Physiological Importance of the Vitaminoid Thiocyanate and Its Influence on Hair Growth
Thiocyanate helps hair growth and can be supplemented in diet or applied topically.
research USES OF ONION (Allium cepa L.) & ALOE VERA (Aloe barbadensis Miller) POST HAIR DYE TREATMENT
Onion and Aloe vera can help protect hair from damage caused by hair dyes.
research Using platelet-rich plasma to treat hair loss and thinning
Injecting platelet-rich plasma into the scalp stimulates hair growth, increases hair density, and treats hair loss effectively with minimal side effects.
research Using platelet-rich plasma to treat hair loss and thinning
Platelet-rich plasma (PRP) injections effectively treat hair loss and thinning in both men and women, with high satisfaction and no major side effects.
research Central Centrifugal Cicatricial Alopecia
Hair loss in African American women, caused by hair care, genetics, and environment, needs more research for better treatment.
research Trichothiodystrophy: Review of sulfur-deficient brittle hair syndromes and association with the ectodermal dysplasias
research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids
The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.
research STITCH: Augmented Dexterity for Suture Throws Including Thread Coordination and Handoffs
STITCH improves suture accuracy and efficiency, especially with human help.