research Clinical relevance of testosterone and dihydrotestosterone metabolism in women
Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.
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research Long-term detection of methyltestosterone (ab-) use by a yeast transactivation system
A yeast-based test can detect the steroid methyltestosterone in urine longer than traditional methods.
research Issues in transgender dermatology: A systematic review of the literature
The review highlights the need for more research on transgender dermatology, the role of dermatologists in gender affirmation, and the effects of hormone therapy on skin and hair.
research Hormone Treatment for the Adult Transgender Patient
Hormone therapy is safe and effective for transgender adults, but requires regular monitoring and mental health support.
research The stimulation of hair growth in the flank organs of female hamsters by subcutaneous testosterone propionate and its inhibition by topical cyproterone acetate: dose-response studies
Testosterone increases hamster hair growth; cyproterone acetate reduces it.
research Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1
Male cells need DHT to respond to testosterone, while female cells do not.
research Optimization of LC method for the determination of testosterone and epitestosterone in urine samples in view of biomedical studies and anti-doping research studies
Researchers developed a reliable method to measure testosterone and epitestosterone in urine for medical and anti-doping use.
research Membrane androgen receptors may mediate androgen reinforcement
Androgen self-administration might be controlled by membrane receptors, not nuclear ones.
research [Effect of selective 5alpha-reductase inhibitor or/and testosterone undecanoate on the reproductive function of male rats].
Testosterone undecanoate can reduce the negative effects of Finasteride on male reproductive health.
research PCPT Results Could Affect Trial on Testosterone Replacement
The trial on testosterone replacement therapy in older men faced concerns due to prostate cancer risk.
research A method for simultaneous analysis of androgens, dutasteride and finasteride in human serum by liquid chromatography tandem mass spectrometry
A new method was developed to analyze certain hormones and drugs in human blood efficiently.
research DIABETE E DOLORE: EFFETTO TERAPEUTICO DEI METABOLITI DEL TESTOSTERONE
Testosterone metabolites may help relieve diabetic nerve pain.
research Androgenic effect of testosterone and some of its metabolites in relation to their biotransformation in the skin.
Testosterone and some of its forms can strongly stimulate oil gland growth in skin.
research Effect of cosmetic hair treatment and natural hair colour on hair testosterone concentrations
Cosmetic hair treatments can increase hair testosterone levels, while natural hair color does not affect it.
research Clinical benefits and adverse effects of genetically-elevated free testosterone levels: a Mendelian randomization analysis
Higher free testosterone levels can increase bone density and decrease body fat but may raise the risk of prostate cancer, hair loss, and benign prostate enlargement.
research Modulating testosterone pathway: a new strategy to tackle male skin aging?
Honokiol might help reduce male skin aging by maintaining testosterone levels.
research Cardiac and brainstem neuroinflammatory pathways account for androgenic incitement of cardiovascular and autonomic manifestations in endotoxic male rats
Testosterone plays a big role in heart and nervous system damage caused by inflammation in male rats, suggesting that blocking testosterone production could help manage this condition.
research Androgen Therapy in Women: An Endocrine Society Clinical Practice Guideline
The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.
research Determination of some sex hormones in health supplements by liquid chromatography with tandem mass spectrometry
The method detected sex hormones in some health supplements, with one containing banned testosterone.
research Androgen Replacement in Women: A Commentary
Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.
research Penis Endocrinology
Hormones, especially testosterone and DHT, are key for penis development and function, and testosterone therapy may help with erectile dysfunction in those with low levels.
research 17-Oximino-5-androsten-3β-yl esters: synthesis, antiproliferative activity, acute toxicity, and effect on serum androgen level
Some synthesized compounds were more effective than Finasteride in reducing prostate cancer cell growth and androgen levels.
research Effects of pre- and post-pubertal dihydrotestosterone treatment on penile length in 5α-reductase type 2 deficiency
Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.
research Breast cancer in a transgender man
Transgender men need personalized cancer care and continued testosterone therapy for well-being.
research Greater conversion of testosterone to 5α-dihydrotestosterone, reflecting increased peripheral 5α-reductase activity in nude mice treated with high doses of cyclosporine A
High doses of cyclosporine A increase testosterone conversion, possibly boosting hair growth.
research The circulating dihydrotestosterone/testosterone ratio is increased by gut microbial 5α-reductase activity in females
Women have a higher DHT/testosterone ratio than men, possibly due to gut bacteria activity.
research Intracrine and Myotrophic Roles of 5α-Reductase and Androgens
Muscles can make their own androgens, which may help muscle growth.
research SUN-049 Male Pattern Baldness and Waist-Hip Ratio as Markers of Arterial Stiffness in Transgender Men Undergoing Long-Term Testosterone Therapy
Male pattern baldness may indicate arterial stiffness in transgender men on long-term testosterone therapy.
research News & Notes
Loop diuretics may double bone loss in elderly men, finasteride lowers prostate cancer risk but may increase high-grade tumors, abarelix reduces testosterone quickly, and transdermal testosterone offers minimal sexual benefit for women.
research Determinants of Plasma Androgen and Estrogen Levels in Men
Understanding testosterone and estradiol levels is crucial for identifying normal and abnormal hormone levels in men, especially as they age.