34 citations
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February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.
12 citations
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June 2007 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” A reliable model for screening type II 5α-reductase inhibitors was created and validated.
August 2022 in “Indonesian Journal of Medical Chemistry and Bioinformatics” Certain herbal compounds might help prevent hair loss in menopausal women by activating Vitamin D receptors.
61 citations
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September 1994 in “The Journal of Clinical Endocrinology and Metabolism” 28 citations
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March 1973 in “The Journal of Clinical Endocrinology & Metabolism” Altered DHEA metabolism in hair follicles may be linked to hair loss in balding men.
November 2025 in “Journal of Investigative Dermatology” Minoxidil helps hair growth by improving blood vessel function.
1 citations
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July 2025 in “Journal of Photochemistry and Photobiology B Biology” Photobiomodulation helps protect hair follicle cells from damage caused by DHT.
2 citations
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January 2022 in “Skin Pharmacology and Physiology” Dexamethasone increases the activity of androgen receptors in human skin cells, which may link it to certain types of hair loss.
6 citations
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December 2021 in “Scientific Reports” Inhibiting class I HDACs helps maintain hair growth ability in skin cells.
January 2006 in “Benzina: Revista d'excepcions culturals” Trienones are more effective at inhibiting the enzyme linked to hair loss than dienones.
39 citations
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March 2018 in “Archives of Dermatological Research” Androgens may block hair growth signals, targeting this could treat hair loss.
August 2013 in “Circulation Research” Finasteride reduces heart enlargement and improves heart function.
July 2025 in “Journal of Investigative Dermatology”
28 citations
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May 1986 in “Clinics in endocrinology and metabolism” New compounds may soon be tested to treat excessive hair growth in women.
1 citations
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December 2019 in “Journal of medicine and life science” Docosahexaenoic acid (DHA) may help hair growth by promoting dermal papilla cell proliferation.
June 2012 in “Nature digest” A substance called prostaglandin D2 is linked to stopping hair growth in men with common baldness.
January 2019 in “Dermatologica Sinica” Dutasteride improved both hair loss and acne in two young men.
5 citations
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July 1994 in “PubMed” Finasteride, when taken daily, lowers dihydrotestosterone levels but doesn't noticeably affect adrenal steroid production, except by blocking the 5 alpha-reductase enzyme.
Finasteride and dutasteride can harm male reproductive health, affecting sperm and causing sexual dysfunction.
21 citations
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December 2015 in “Development Growth & Differentiation” DHT is crucial for urethral formation, and its disruption can affect masculinization and lead to hypospadias.
219 citations
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October 2009 in “Steroids” 5α-reductase inhibitors, like Finasteride and Dutasteride, help manage benign prostatic hyperplasia.
12 citations
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March 2017 in “Medicinal Chemistry Research” Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.
20 citations
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June 1995 in “Tetrahedron Letters” New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.
10 citations
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October 2010 in “International Journal of Andrology” Finasteride doesn't affect oral testosterone undecanoate, and high DHT levels may cause acne, prostate issues, and hair loss.
78 citations
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November 2005 in “Endocrinology” Hairless protein can block vitamin D activation in skin cells.
46 citations
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March 2001 in “Journal of endocrinological investigation” 5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.
56 citations
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December 2002 in “The Journal of Clinical Endocrinology & Metabolism” Human bone cells mainly produce a type 1 enzyme that may help regulate bone health.
May 2012 in “Scientific American” Blocking a compound called prostaglandin D₂ might help treat hair loss.
April 2017 in “Austin Journal of Cancer and Clinical Research” 5α-reductase inhibitors like Finasteride and Dutasteride may help manage prostate cancer by blocking testosterone conversion.
14 citations
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September 2006 in “Experimental Dermatology” Interleukin‐1 α reduces androgen receptor levels and increases certain cytokines in human scalp cells.