research Fish Cell Spheroids, a Promising In Vitro Model to Mimic In Vivo Research: A Review
Fish cell spheroids are a promising tool for replicating real-life conditions in research.
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research The Osler Lecture 2012 'Pharmacology 2.0, medicines, drugs and human enhancement'
The lecture concluded that drugs for human enhancement are here to stay and called for their responsible development and fair access.
research An industry update: what’s new in the field of therapeutic delivery this month?
New drugs for Alzheimer's and rheumatoid arthritis advanced, a Zika vaccine is in development, and there were business deals in anesthesia and oncology.
research Workplace Drug Testing Using Hair Samples
Hair testing is a reliable method for detecting workplace drug use when done with proper sample preparation and confirmation.
research Grand challenges in dermatologic drug discovery: four priorities to transform skin disease treatment
Transforming skin disease treatment requires new strategies, better drug models, and patient-focused research.
research Geometric classification of scalp hair for valid drug testing, 6 more reliable than 8 hair curl groups
A 6-group hair classification is more reliable for drug testing than an 8-group system.
research Anti‐Doping Testing at FIFA World Cup 2022
All samples tested negative for banned substances, ensuring competition integrity.
research Diagnostic challenges in determining alopecia areata
Diagnosing alopecia areata is challenging and requires careful examination and various tests to distinguish it from other hair loss types.
research Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System
New skin disease treatments using TDDS are improving but face challenges like side effects and high costs.
research Exploring the Versatility of Microemulsions in Cutaneous Drug Delivery: Opportunities and Challenges
Microemulsions could improve skin drug delivery but face challenges like complex creation and potential toxicity.
research Drug-Loaded Extracellular Vesicle-Based Drug Delivery: Advances, Loading Strategies, Therapeutic Applications, and Clinical Challenges
EV-based drug delivery shows promise but faces challenges in standardization and scalability.
research Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches
Drug repositioning is a promising way to quickly develop new treatments, especially for rare diseases.
research In vitro hair follicle growth model for drug testing
Researchers developed a new method to test hair growth drugs and found that adult cells are best for hair growth, but the method needs improvement as it didn't create mature hair follicles.
research Recent Insights into the Potential and Challenges of Sericin as a Drug Delivery Platform for Multiple Biomedical Applications
Sericin from silk cocoons could be a promising drug delivery tool, but stability and consistency need improvement.
research Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing of Topical Dermatologic Products
The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.
research Ocfentanil testing in hair from a fatality case: Comparative analysis of a lock of hair versus a single hair fiber
Both a lock of hair and a single hair strand can show chronic drug use, but at least six single hairs are needed for accurate results.
research Improved forensic hair evidence for drugs of abuse by mass spectrometry
Forensic hair analysis for drugs is now more reliable and accurate.
research The C3H/HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results
Both mouse and rat models are effective for testing alopecia areata treatments.
research Can an in vitro hair drug model be developed using dermal papilla cells alone?
Dermal papilla microtissues could be useful for initial hair growth drug testing.
research Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies
Extracellular vesicles show promise for treating diseases but face challenges in development and regulation.
research Drug eruptions in dermatology
Skin reactions to drugs are common and can be deadly, usually requiring stopping the drug and may be better prevented with genetic testing in the future.
research Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19
Cepharanthine, a Japanese hair loss drug, shows promise as a COVID-19 treatment but needs more testing.
research Late presentation of myotonic dystrophy
Myotonic dystrophy should be considered in patients with hair thinning, and genetic counseling is important.
research The 39th Manfred Donike workshop on doping analysis
The 39th Manfred Donike Workshop discussed methods for detecting misuse of steroids, gene doping, and the complexity of identifying drug residues in urine, highlighting the ongoing efforts to improve global anti-doping work.
research The potential for occupational exposure of veterinarians to ketamine resulting in positive drug tests
Veterinarians could test positive for ketamine from work exposure, not just substance abuse.
research The role of 3Rs in the age of One Health: where we are and where we’re going
Innovative methods are reducing animal testing and improving biomedical research.
research (Un)targeted Scanning of Locks of Hair for Drugs of Abuse by Direct Analysis in Real Time–High-Resolution Mass Spectrometry
A new method can quickly and accurately detect drugs in hair.
research Can dermal delivery of therapeutics be improved using thermoresponsive nanogels?
Thermoresponsive nanogels show promise for delivering medicine through the skin but need more safety testing and regulatory approval before clinical use.
research An overview of current strategies and future prospects in drug repurposing in tuberculosis
Drug repurposing offers promising strategies to improve tuberculosis treatment despite challenges.
research Drug repurposing: Clinical practices and regulatory pathways
Drug repurposing offers faster, cheaper drug development but faces challenges like safety, ethics, and funding.