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A new syndrome was linked to two new genetic changes in the MBTPS1 gene in a 14-year-old girl.

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

Blocking DGAT1 reduces oil gland size in mice and dogs, but only mice experience hair loss.

Removing Gsdma1/2/3 genes reduces skin cell overgrowth by blocking a specific cell pathway.

Dapagliflozin improved blood sugar control in a man with Werner syndrome without side effects.

The ZIP13 variant is linked to abnormal hair quality.

A new gene variant in the DSP gene is linked to a unique type of hair loss.

SCD1 is crucial for skin health and overall energy balance.

Dried blood spots can be as stable as frozen liquid samples for storing certain metabolites.

Higher levels of the DP2 receptor may lead to hair loss.

Mutations in the DSG4 gene cause a severe form of brittle hair and skin issues.

Lack of sleep in mice leads to prostatitis by reducing certain hormones and activating an inflammatory pathway, which can be temporarily fixed with normal sleep.

Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, which could be a new target for treating hair loss and other skin conditions driven by testosterone.

ACOD1 deficiency worsens hair loss by causing cell aging and mitochondrial problems, but 4-OI may help.

Blocking 11β-HSD1 reduces stress hormone damage in hair growth cells.

Syndecan-1 is essential for maintaining skin fat and preventing cold stress.

THAP1 gene changes do not affect DYT1 dystonia; finasteride may help reduce tics and OCD in Tourette syndrome.

Blocking 11β-HSD1 can lessen the harmful effects of glucocorticoids on hair growth cells.

Targeted protein degraders show promise in treating cancer but need to target more diverse proteins.

A gene deletion in DSG4 causes sparse hair in some Pakistani families.

Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.

Gasdermin A3 causes hair follicle stem cells to activate too early, leading to hair loss.

Disrupting a specific protein's function in hair follicle stem cells triggers their activation and a self-healing process.

Gorab deficiency speeds up skin aging by disrupting protein regulation and reducing collagen.

A small change in the TRPS1 gene leads to a less severe form of a syndrome affecting hair, nose, and finger development.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

A specific gene mutation causes a severe skin disorder in a family.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.