January 2026 in “Dermatology Practical & Conceptual” Nail changes are common in alopecia areata and can indicate its severity.
July 2021 in “PARIPEX INDIAN JOURNAL OF RESEARCH” Knuckle darkening can be an early sign of vitamin B12 deficiency.
12 citations
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March 2021 in “JAAD Case Reports” Nail changes from immunotherapy can be managed without stopping cancer treatment.
The study concludes that Twenty-nail dystrophy is more common in boys among children and in women among adults, with varying response to treatment.
January 2021 in “Skin Appendage Disorders”
December 2023 in “Royal Society of Chemistry eBooks” Nails are a useful alternative to hair for analyzing long-term substance exposure.
Hair and nail disorders can harm self-esteem, but early treatment helps.
13 citations
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June 2010 in “Journal of The American Academy of Dermatology” A man with Cronkhite-Canada syndrome had all 20 nails detach but improved with treatment.
February 2023 in “International Journal of Dermatology” February 2026 in “JEADV Clinical Practice” Nail pitting in kids can be harmless or indicate other health issues, so thorough evaluation is crucial.
April 2019 in “International journal of research in dermatology” A child with rough nails also had hair loss and allergies.
May 2018 in “Dermatologic Surgery” 6 citations
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June 2024 in “Drug Testing and Analysis” Nails could be used to check long-term drug use, but more research is needed.
19 citations
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January 2018 Most people with alopecia areata have nail changes, which are common but don't greatly affect their quality of life.
58 citations
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November 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” The Foxn1 gene is essential for normal nail and hair development.
16 citations
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August 1992 in “Archives of dermatological research” Lab-grown nail cells show characteristics similar to natural nail and hair.
The nail immune system is similar to hair but different from skin, with fewer immune markers.
44 citations
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May 1980 in “Archives of Dermatology” "20-nail dystrophy" can have multiple causes.
18 citations
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March 1974 in “Acta dermato-venereologica” Chronic kidney disease can cause skin and nail problems.
5 citations
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January 2012 in “Journal of nutrition & food sciences” The supplement improved hair, skin, and nails appearance and had long-term benefits.
16 citations
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February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
55 citations
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February 2013 in “The Anatomical Record” Mouse nails are similar to human nails, making them useful for studying nail diseases.
October 2023 in “CRC Press eBooks” Children with darker skin can have various hair and nail issues.
March 2026 in “Scholars Journal of Medical Case Reports” Nail issues are common in kids with alopecia areata and should be checked for better diagnosis.
2 citations
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May 2009 in “Medicine” Hair and nails can help diagnose diseases, with nail issues often linked to skin conditions and hair loss having various causes and treatments.
September 2022 in “JAAD case reports” The man has a genetic skin condition called pachyonychia congenita.
January 1939 in “Münchener medizinische Wochenschrift”
January 2025 in “International Journal of Dermatology Sciences” Nail changes in alopecia areata are common and may indicate severity and genetic risk.
30 citations
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May 1980 in “Journal of the American Academy of Dermatology” Alopecia areata can cause spotty white areas on nails.
1 citations
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January 2010 in “Springer eBooks” Certain micronutrients may improve hair and nail health, but more research is needed to confirm their benefits.