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GlossaryDystrophic Anagen Hairs

hairs in active growth phase but abnormally weak and thin

Dystrophic anagen hairs are hairs that are in the active growth phase (anagen) but are abnormally thin, weak, and often break easily due to damage or underlying health conditions. This can be caused by factors such as nutritional deficiencies, autoimmune disorders like alopecia areata, or physical trauma to the hair follicles.

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research Patients with profuse hair shedding may reveal anagen hair dystrophy: a diagnostic clue of alopecia areata incognita

31 citations , October 2010 in “Journal of the European Academy of Dermatology and Venereology”

Some people with heavy hair shedding might actually have a hidden form of alopecia, which can be identified by specific hair changes.

research Pretreatment of epidermal growth factor promotes primary hair recovery via the dystrophic anagen pathway after chemotherapy‐induced alopecia

25 citations , May 2013 in “Experimental Dermatology”

Epidermal growth factor helps hair recover after chemotherapy.

research Dystrophic-Anagen Effluvium Occurring During Pegylated Interferon-α-2a/Ribavirin Therapy

2 citations , March 2015 in “Hepatitis Monthly”

A woman's hair loss during Hepatitis C treatment with PEG-INF-a-2a and Ribavirin was reversible after stopping the medication.

research Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression

69 citations , May 1997 in “Veterinary Pathology”

The angora mouse mutation causes long hair and hair defects due to a gene deletion.

research Hair loss during lithium treatment

29 citations , July 1982 in “British Journal of Dermatology”

Lithium treatment can cause increased hair shedding and hair loss in patients.

research Hair Shaft Abnormalities. Pili Bifurcati: A Scanning Electron Microscopy Analysis

5 citations , March 2009 in “Pediatric Dermatology”

The study found that pili bifurcati causes hair to intermittently split into two branches, each with its own outer layer.

Anagen Effluvium Due to Thallium Poisoning from Chinese Herbal Medicine and Rodenticide Containing Thallium Salts

research Anagen effluvium due to thallium poisoning derived from the intake of Chinese herbal medicine and rodenticide containing thallium salts

5 citations , June 2015 in “Journal of dermatology”

A woman and her daughter had thallium poisoning from a herbal drink and rodenticide, causing hair loss and other symptoms.

research What can the hair tell us about COVID‐19?

27 citations , December 2020 in “Experimental Dermatology”

Grey hair and baldness may be linked to COVID-19 severity, but more analysis is needed; post-infectious hair loss is related to the severity of the disease and usually recovers within 3-6 months.

Hair Loss in Cancer Chemotherapy Patients

research Hair loss in cancer chemotherapeutic patients.

10 citations , July 2007 in “PubMed”

Chemotherapy causes hair loss in cancer patients by affecting both growing and resting hair.

research Reply to early onset effluvium secondary to COVID-19 and body-hair effluvium

December 2021 in “Journal of The American Academy of Dermatology”

COVID-19 can cause different types of hair loss, which may last up to 100 days, and treatments are still being explored.

research A patient with diffuse hair loss

January 2015 in “Indian Dermatology Online Journal”

The patient's hair loss is most likely due to diffuse alopecia areata.

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations , June 2005 in “Journal of Investigative Dermatology”

The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.

research Pretreatment with epidermal growth factor promotes primary hair recovery in the chemotherapy-induced alopecia

January 2013 in “Seoul National University Open Repository (Seoul National University)”

Epidermal growth factor helps hair regrow after chemotherapy.

research Hair root studies in patients suffering from primary and secondary syphilis

6 citations , May 1987 in “Acta dermato-venereologica”

Syphilis patients showed abnormal hair root changes, with no difference between primary and secondary stages.

research Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice

31 citations , August 2000 in “Journal of Investigative Dermatology”

Stem cells are key for hair follicle recovery.

research Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation

19 citations , November 2001 in “Journal of Investigative Dermatology Symposium Proceedings”

Human hair follicles can regenerate and recover after severe injury by going through a brief abnormal resting phase before growing again.

Widespread Dystrophic-Anagen Alopecia and Drug Eruption Due to Usage of PEG-IFN Alpha-2a/Ribavirin Combination Therapy

research Widespread Dystrophic-Anagen Alopecia and Drug Eruption due to Usage of PEG-IFN ?-2a /Ribavirin Combination Therapy

1 citations , January 2014 in “Hair therapy & transplantation”

The combination therapy of PEG-IFN α-2a and Ribavirin can cause widespread hair loss and skin reactions.

research An Experimental Study of Morphofunctional Features of Hair Follicles Early Response in Cyclophosphamide-Induced Alopecia

September 2024 in “Journal of Anatomy and Histopathology”

Miliacin helps damaged hair follicles grow new hair faster.

research Lanceolate Hair (lah): A Recessive Mouse Mutation with Alopecia and Abnormal Hair

36 citations , July 1996 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice with the 'lanceolate hair' mutation have abnormal hair and skin similar to human Netherton's syndrome.

research Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-mediated Root Sheath Disruption in Advance of Overt Hair Loss

37 citations , November 2003 in “Veterinary pathology”

Hair loss in mice starts with immune cells damaging hair roots before it becomes visible.

research Histopathology of Hypotrichosis with Juvenile Macular Dystrophy

19 citations , May 2004 in “The American Journal of Dermatopathology”

The research found that a specific gene mutation causes fewer hair follicles and disrupted hair growth cycles, leading to thin and short hair in people with Hypotrichosis with Juvenile Macular Dystrophy.

research Disorders of the Hair and Nails

1 citations , January 2013 in “Elsevier eBooks”

The document reviews various hair and nail disorders, their causes, and treatments, emphasizing the need for proper diagnosis and the link between nail changes and systemic diseases.

research Why Do Not All Chemotherapy Patients Lose Their Hair? Answering an Intriguing Question

1 citations , January 2021 in “Skin appendage disorders”

Chemotherapy patients don't all lose their hair due to factors like hair growth rates, age, genetics, and the type of drugs used.

research Clinical relevance of hair microscopy in alopecia

15 citations , July 2002 in “Clinical and Experimental Dermatology”

Hair microscopy is useful for diagnosing certain hair loss conditions but has limitations and must be interpreted carefully.

research Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro

6 citations , August 2019 in “PLOS ONE”

Gambogic Amide helps maintain hair color and promotes hair growth.

research FGF signaling for hair cycle resting phase alleviates radiation alopecia

1 citations , September 2016 in “Journal of Dermatological Science”

FGF18 treatment during hair's resting phase can protect against hair loss from radiation.

The Role of P-Cadherin in Skin Biology and Pathology: Lessons from the Hair Follicle

research The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle

15 citations , February 2015 in “Cell & tissue research/Cell and tissue research”

P-cadherin is important for hair growth and health, and its problems can cause hair and skin disorders.

research Mimicking Senescence Factors to Characterize the Mechanisms Responsible for Hair Regression and Hair Loss: An In Vitro Study

July 2025 in “Organoids”

TGF-β1 and FGF-18 are key in hair loss, and Minoxidil helps hair growth.

research Skin signs in the diagnosis of thallium poisoning

48 citations , February 1998 in “British Journal of Dermatology”

Thallium poisoning can cause severe neurological symptoms and hair loss.

Clinical and Histological Challenge in the Differential Diagnosis of Diffuse Alopecia: Female Androgenetic Alopecia, Telogen Effluvium and Alopecia Areata – Part I

research Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata – part I

29 citations , October 2012 in “Anais Brasileiros De Dermatologia”

Diagnosing hair loss disorders needs clinical, dermoscopic, and histological differences, and checking menstrual cycle, weight changes, drug therapy, and nail changes.