February 2010 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Finasteride can cause skin reactions, so dermatologists should be aware.
April 2017 in “Actas urológicas españolas” 5-alpha reductase inhibitors increase the risk of sexual dysfunction in patients treating enlarged prostate but not in those treating hair loss.
7 citations
,
September 1997 in “PubMed”
35 citations
,
January 2012 in “The Journal of Sexual Medicine” Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.
2 citations
,
May 2017 in “Zenodo (CERN European Organization for Nuclear Research)” Topical minoxidil 5% can cause erectile dysfunction and decreased libido.
January 2025 in “Clinical and Experimental Optometry” Men with androgenetic alopecia may have more severe dry eye and meibomian gland dysfunction.
January 2025 in “Journal of Men s Health” Young men's erectile dysfunction is linked to mental health issues and risky behaviors promoted by online communities, highlighting the need for better mental health support and healthy masculinity standards.
1 citations
,
October 2024 in “JCEM Case Reports” 5α-reductase deficiency can cause ambiguous genitalia and gender dysphoria, treatable with testosterone.
November 2022 in “Hair transplant forum international” Finasteride does not cause sexual dysfunction in men with hair loss.
1 citations
,
April 2025 in “Journal of Clinical Medicine” Hair loss in alopecia areata can negatively affect sexual quality of life.
February 2026 in “The Journal of Sexual Medicine” GnRH agonists can help manage recurrent priapism in sickle cell patients, but long-term safety is unclear.
1 citations
,
July 2015 in “Cambridge University Press eBooks” Testosterone therapy can improve sexual function in women but long-term safety is unclear.
111 citations
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August 2015 in “Reviews in Endocrine and Metabolic Disorders” 5α-reductase inhibitors may cause persistent sexual dysfunction and depression, needing more research on long-term effects.
July 2016 in “Reactions Weekly” Cyproterone and finasteride reduced hypersexuality but caused serious side effects.
May 2015 in “Journal of The American Academy of Dermatology” Young men taking finasteride for hair loss have a higher risk of sexual dysfunction.
9 citations
,
July 2003 in “International Journal of Clinical Practice” Age and other health issues affect erectile dysfunction more than finasteride or alpha-blockers.
2 citations
,
September 2007 in “International Journal of Impotence Research” Local testosterone treatment improved sexual desire in a female with fragile X syndrome.
February 2024 in “The Journal of Sexual Medicine” 5-α reductase inhibitors do not significantly affect male reproductive function but may reduce semen volume.
May 2022 in “The Journal of Sexual Medicine” Finasteride is linked to sexual dysfunction, especially in younger men using it for hair loss.
October 2010 in “Journal of Men's Health” The conclusion is that doctors should be careful when prescribing 5α-reductase inhibitors due to possible serious side effects, and they should discuss these risks with patients.
April 2026 in “The Journal of Urology” Low-dose finasteride may increase erectile dysfunction risk over time.
29 citations
,
July 2012 in “The Journal of Sexual Medicine” Rats had lasting erectile problems after stopping a certain medication.
The paper suggests that a decrease in estrogen receptor activity may cause sexual dysfunction syndromes and proposes hormonal treatments.
June 2026 in “British Journal of Dermatology” Finasteride mildly affects semen but is reversible; dutasteride has stronger effects with incomplete recovery.
38 citations
,
October 2014 in “Current Opinion in Endocrinology, Diabetes and Obesity” 5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.
January 2018 in “Elsevier eBooks” 5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.
April 2026 in “The Journal of Urology” Finasteride and dutasteride reduce semen quality, with dutasteride having a stronger negative effect.
6 citations
,
October 2011 in “ISRN Ophthalmology” Higher testosterone and dehydroepiandrosterone sulphate levels may help diagnose meibomian gland dysfunction.
January 2025 in “JCEM Case Reports” Enzyme replacement therapy may help alleviate symptoms in complex cases like this.