374 citations
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May 2016 in “The Lancet. Diabetes & endocrinology” Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.
277 citations
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July 2002 in “Molecular Endocrinology” Removing part of the vitamin D receptor stops vitamin D from working properly.
256 citations
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October 2013 in “Nature Communications” Bioengineered lacrimal glands can restore tear production and protect eyes.
185 citations
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June 2014 in “Journal of Investigative Dermatology” A man with severe hair loss and skin disease regrew his hair with no side effects after taking tofacitinib.
151 citations
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July 2011 in “Archives of Dermatological Research” Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.
142 citations
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December 1991 in “Antimicrobial Agents and Chemotherapy” Dextran sulfate was found to be toxic and ineffective for treating HIV.
116 citations
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December 2013 in “European journal of endocrinology” Combining liraglutide and metformin helps obese women with PCOS who didn't lose weight on metformin alone to lose more weight.
102 citations
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September 1977 in “The Lancet” Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.
100 citations
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March 1973 in “American Journal of Cardiology” Minoxidil effectively lowers blood pressure without major side effects.
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January 2000 in “The Journal of Clinical Endocrinology and Metabolism” Spironolactone most effective for hirsutism, but has side effects.
92 citations
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October 2002 in “Journal of The American Academy of Dermatology” Finasteride improves hair loss in women with hyperandrogenism.
86 citations
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May 2013 in “American journal of obstetrics and gynecology” Gynecologists should provide comprehensive care for transgender patients, including mental health evaluation, hormone therapy, and surgical options, while monitoring for side effects and ensuring patient safety.
83 citations
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April 1992 in “Clinical Endocrinology” Having enough iron improves the effectiveness of a specific hair loss treatment in women.
82 citations
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April 1981 in “Clinical endocrinology” A girl with rickets and hair loss was found to have a rare condition where her body didn't respond to vitamin D treatment.
81 citations
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July 2012 in “Translational Psychiatry” Memantine may slightly improve memory in people with Down syndrome, but more research is needed.
80 citations
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December 2017 in “International Journal of Dermatology” Low-dose oral minoxidil and spironolactone combo effectively reduces hair loss and improves hair density in women.
80 citations
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September 1984 in “Journal of The American Academy of Dermatology” 5% minoxidil helps hair regrowth in androgenic alopecia.
75 citations
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November 1996 in “Fertility and Sterility” Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.
74 citations
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September 1980 in “Medical Clinics of North America” Toxic epidermal necrolysis is a severe skin condition often caused by drugs, with complex treatment and a high risk of death, but survivors usually heal without scars.
71 citations
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January 2004 in “Dermatology” Oral finasteride works better than topical minoxidil for hair growth, both are safe.
61 citations
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January 2015 in “Hormones” Liraglutide caused significant weight loss in some obese women with PCOS, especially those with severe obesity and insulin resistance.
59 citations
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February 2003 in “Veterinary Dermatology” Cyclosporin is effective for treating skin conditions in small animals, but requires careful dosing and monitoring for side effects.
56 citations
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April 2003 in “Fertility and Sterility” All three treatments reduce hirsutism, but spironolactone works best long-term.
55 citations
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February 1985 in “Archives of Dermatology” Using minoxidil on the scalp can help grow hair for people with hereditary baldness.
55 citations
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October 1975 in “Circulation” Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.
54 citations
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May 2017 in “Biomedicine & Pharmacotherapy” Edible seeds from the Cucurbitaceae family like pumpkin and watermelon seeds are nutritious and may have health benefits, but eating too much can cause side effects.
51 citations
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May 2010 in “Journal of Drug Targeting” Transcutol-containing vesicles improve minoxidil's skin penetration and hair growth promotion.
49 citations
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August 1996 in “The Journal of Clinical Endocrinology and Metabolism” The combination of cyproterone acetate and testosterone enanthate is highly effective in preventing sperm production and could be a good reversible male contraceptive.
48 citations
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October 2011 in “Sports Medicine” Ice-skating athletes often have skin problems due to cold, infections, and inflammation, needing careful treatment and prevention.
47 citations
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August 2000 in “Endocrine Reviews” The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.