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Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

The conclusion is that hirsutism should be diagnosed and treated because it affects quality of life and may signal other health problems.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Melatonin protects skin against UV damage by regulating various cellular processes.

Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.

New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

lncRNA XLOC_008679 and gene KRT35 affect cashmere fineness in goats.

The document concludes that proper diagnosis and combined treatments are key for hirsutism management, and weight loss may help overweight patients.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

PCOS may start before birth, involves metabolic issues, and can be treated with drugs like metformin and lifestyle changes.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

New treatments for low male hormones improved sexual function and mood but had unclear risks, especially for older men.

Aromatic plants can naturally help prevent skin aging and improve skin health.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Interferons are effective for some skin conditions and cancers, but can have side effects and need more research for optimal use.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Newborn skin is uniquely prepared to adapt to new environments compared to adult skin.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Puberty often causes skin issues like acne and excessive sweating, and treatments require patience as results may vary.

New treatments for skin conditions related to the sebaceous gland are being developed based on current research.

Finasteride helps protect brain in old male rats.