16 citations
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November 2018 in “The journal of pain/Journal of pain” 14,15-EET may help reduce poststroke pain by affecting certain brain proteins.
16 citations
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November 2024 in “Human Genetics and Genomics Advances” Nociplastic pain is a complex, heritable trait with genetic links to chronic and neuropathic pain.
August 2016 in “Journal of Investigative Dermatology” The endocannabinoid system affects oil production and inflammation in skin cells.
15 citations
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September 1999 in “British Journal of Dermatology” Epimorphin, a protein, plays a key role in the development of hair follicles in human fetuses, but it doesn't help in maintaining the stem cell population of the follicular skin layer.
May 2026 in “Commagene Journal of Biology” Anti-aging peptides are promising in cosmeceuticals for improving skin appearance by targeting biological mechanisms of skin aging. They stimulate extracellular matrix protein synthesis, inhibit matrix-degrading enzymes, enhance skin barrier integrity, suppress inflammation, and modulate micro-muscle contractions. Despite their potential and generally favorable safety profiles, challenges such as peptide stability, purity, effective skin penetration, and limited standardized clinical data remain. Future advancements in delivery technologies and rigorous clinical research are necessary to overcome these barriers and enhance the effectiveness of peptide-based formulations.
66 citations
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July 2007 in “Journal of Molecular Medicine” Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.
11 citations
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March 2017 in “Journal of Biomedical Semantics” The Drug Ontology was updated to better classify drugs for hypertension, malaria, and opioid abuse, and to allow for more accurate research queries.
26 citations
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January 1992 in “Carcinogenesis” TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.
New peptides can delay aging and improve cell function.
1 citations
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May 2025 in “Natural Products and Bioprospecting” PEVIII is a promising treatment for Pseudomonas aeruginosa keratitis.
9 citations
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August 2023 in “Molecules” Two peptides, RMYYY and VMYMI, may be effective anti-inflammatory drugs.
July 2024 in “Journal of Investigative Dermatology” Certain substances can help skin cells become anti-inflammatory, aiding in tissue repair.
43 citations
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May 1999 in “Journal of Biological Chemistry” Agouti protein affects melanocortin receptors through competitive antagonism and receptor down-regulation.
21 citations
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September 2019 in “International Journal of Nanomedicine” RADA16-I can effectively deliver and release mangiferin, improving its solubility and bioavailability.
Sphingosine 1-phosphate helps control mechanical pain.
May 2020 in “Authorea (Authorea)” Olfactory receptors found outside the nose may offer new treatments for diseases like cancer and help in wound healing and hair growth.
48 citations
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January 2003 Endophytes from Southeast Asia and Japan can produce useful substances like enzymes and antibiotics.
10 citations
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April 2022 in “Critical reviews in food science and nutrition” Skin odorant receptors respond to flavors and could be targeted to improve skin health and treat diseases.
99 citations
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August 1998 in “Pain” Blocking GABA(A) receptors increases neuron sensitivity, showing GABA and glycine have different roles in pain.
8 citations
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September 2021 in “EMBO Molecular Medicine” A new small peptide may help hair growth by activating a specific receptor and should be tested in humans.
1 citations
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October 2023 in “Egyptian Journal of Immunology” PCOS is linked to low-grade chronic inflammation.
91 citations
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May 2003 in “PubMed” Neuroactive steroids affect cocaine's rewarding effects through the sigma1 receptor.
33 citations
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June 1995 in “International journal of legal medicine” Environmental factors can greatly reduce drug levels in hair.
17 citations
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December 2001 in “Journal of Investigative Dermatology” The osteopontin gene is active in a specific part of rat hair follicles during a certain hair growth phase and might affect hair cycle and diseases.
6 citations
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May 2022 in “Colloids and Surfaces B: Biointerfaces” Eating peptides from certain shellfish may help wounds heal faster by reducing inflammation.
8 citations
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February 2023 in “American Journal of Physiology-Cell Physiology” Adiponectin and bradykinin play important roles in skin health and may help treat skin conditions.
4 citations
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December 2010 in “Copernican Letters” Synthetic polypeptides in cosmetics may help with anti-aging, but their effectiveness on real skin is uncertain.
4 citations
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April 2017 in “F1000Research” Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.
23 citations
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December 2008 in “Current medicinal chemistry” Stimulating sensory neurons can increase IGF-I production, which may help treat various diseases and improve tissue health.
October 2014 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” A new type of nerve cell involved in itch perception was discovered.