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GlossaryVascular Endothelial Growth Factor

stimulates new blood vessel formation

Vascular Endothelial Growth Factor (VEGF) is a protein that stimulates the formation of new blood vessels. It plays a crucial role in both normal processes like wound healing and the growth of hair, as well as in pathological conditions such as cancer, where it can promote tumor growth by increasing blood supply.

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research Differentiation of human hair follicle stem cells into endothelial cells induced by vascular endothelial and basic fibroblast growth factors

24 citations , November 2013 in “Molecular Medicine Reports”

Human hair follicle stem cells can become endothelial cells with certain growth factors, useful for vascular treatments.

Extracellular Vesicles From 3D Cultured Dermal Papilla Cells Improve Wound Healing Via Krüppel-Like Factor 4/Vascular Endothelial Growth Factor A-Driven Angiogenesis

research Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis

1 citations , January 2023 in “Burns and trauma”

Tiny particles from 3D-grown skin cells speed up wound healing by promoting blood vessel growth.

research Endothelium-derived relaxing factor and minoxidil: active mechanisms in hair growth

1 citations , August 1989 in “Archives of Dermatology”

Minoxidil may promote hair growth by mimicking a natural body process.

research Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells

192 citations , March 1998 in “British Journal of Dermatology”

Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

research Expression of vascular endothelial growth factor (VEGF) in various compartments of the human hair follicle

105 citations , December 1998 in “Archives of Dermatological Research”

Dermal papilla cells mainly drive blood vessel growth in hair follicles.

research Capture of endothelial cells under flow using immobilized vascular endothelial growth factor

60 citations , February 2015 in “Biomaterials”

A surface with VEGF can specifically capture endothelial cells from flowing fluids.

research Promoted growth of murine hair follicles through controlled release of vascular endothelial growth factor

56 citations , June 2002 in “Biomaterials”

Controlled release of VEGF in a collagen hydrogel boosts hair growth in mice.

Hair Growth Promoting Effect of Dermal Papilla-Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells Through Vascular Endothelial Growth Factor

research Hair growth promoting effect of dermal papilla like tissues from canine adipose-derived mesenchymal stem cells through vascular endothelial growth factor

8 citations , January 2016 in “Journal of Veterinary Medical Science”

Lab-made tissues from dog fat stem cells can help grow hair by releasing a growth factor.

Recombinant Human Growth Hormone Promotes Burn Wound Repair by Regulating Vascular Endothelial Growth Factor and Microvessel Density

research Recombinant Human Growth Hormone Promotes Burn Wound Repair by Regulating Vascular Endothelial Growth Factor and Micro Vessel Density

January 2024

Recombinant human growth hormone helps burn wounds heal faster by increasing blood vessel growth.

Evaluation of Serum Levels of Vascular Endothelial Growth Factor in Female Patients with Telogen Effluvium

research Evaluation of Serum Levels of Vascular Endothelial Growth Factor (VEGF) in Female Patients with Telogen Effluvium

March 2018 in “Benha Journal of Applied Sciences”

Women with telogen effluvium have lower levels of VEGF, which may contribute to their hair loss.

research Topical Rice Bran Oil (Oryza sativa L.) Has The Same Effect With 2% Topical Minoxidil To Prevent Senile Alopecia Through Improved Vascular Endothelial Growth Factor (VEGF) Protein Expression, Hair Follicle Diameter And Length In Wistar Rats (Rattus norvegicus) Exposed To Ultraviolet B Light

January 2023 in “International journal of research publications”

Rice bran oil works as well as 2% minoxidil to prevent hair loss and promote hair growth.

research Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study

58 citations , May 2004 in “British Journal of Dermatology”

Diphenylcyclopropenone treatment helps hair growth in alopecia areata by promoting blood vessel growth and cell survival.

research Role of vascular endothelial growth factor in hair follicle biology

January 2009 in “International Journal of Pathology and Clinical Medicine”

VEGF is important for hair growth and cycle control.

research Effects of latanoprost on vascular endothelial growth factor protein synthesis in human dermal papilla cells

January 2006

Latanoprost increases VEGF protein in human cells, which may help hair growth.

research Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia

100 citations , August 2008 in “American Journal Of Pathology”

VEGF-A is crucial for normal skin function and may be linked to psoriasis.

The Effect of Finasteride on the Expression of Vascular Endothelial Growth Factor and Microvessel Density: A Possible Mechanism for Decreased Prostatic Bleeding in Treated Patients

research The Effect of Finasteride on the Expression of Vascular Endothelial Growth Factor and Microvessel Density: A Possible Mechanism for Decreased Prostatic Bleeding in Treated Patients

90 citations , January 2003 in “The Journal of Urology”

Finasteride may reduce prostate bleeding by lowering blood vessel growth factor levels and blood vessel density in certain prostate areas.

research Regulation of microvascular permeability by vascular endothelial growth factors

48 citations , May 2002 in “Journal of Anatomy”

VEGFs increase blood vessel permeability, especially in diseases like cancer and heart disease.

research Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles

47 citations , May 1995 in “Journal of Investigative Dermatology”

Hair follicles in people with alopecia have lower levels of a key blood vessel growth protein.

Gelatin-Chondroitin-6-Sulfate-Hyaluronic Acid Scaffold Seeded with Vascular Endothelial Growth Factor 165 Modified Hair Follicle Stem Cells as a Three-Dimensional Skin Substitute

research Gelatin-chondroitin-6-sulfate-hyaluronic acid scaffold seeded with vascular endothelial growth factor 165 modified hair follicle stem cells as a three-dimensional skin substitute

45 citations , October 2014 in “Stem cell research & therapy”

Modified rat stem cells on a special scaffold improved blood vessel formation and wound healing in skin substitutes.

research Effects of Finasteride on Vascular Endothelial Growth Factor

35 citations , January 2002 in “Scandinavian Journal of Urology and Nephrology”

Finasteride reduces prostate bleeding by affecting blood vessel growth.

research Differing responses of human follicular and nonfollicular scalp cells in an in vitro wound healing assay: Effects of estrogen on vascular endothelial growth factor secretion

30 citations , March 2008 in “Wound Repair and Regeneration”

Estrogen affects scalp cell types differently, enhancing some wound healing processes.

17β-Estradiol Enhances Vascular Endothelial Growth Factor Production and Dihydrotestosterone Antagonizes the Enhancement via the Regulation of Adenylate Cyclase in Differentiated THP-1 Cells

research 17β-Estradiol Enhances Vascular Endothelial Growth Factor Production and Dihydrotestosterone Antagonizes the Enhancement via the Regulation of Adenylate Cyclase in Differentiated THP-1 Cells

18 citations , March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Estrogen increases blood vessel growth factor production, while testosterone blocks this increase.

Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

research Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

11 citations , September 2019 in “Dermatologic Surgery”

A substance called Vascular Endothelial Growth Factor can protect certain hair follicle stem cells from damage caused by androgens, suggesting a new possible treatment for hair loss.

Comparison Between Single- Versus Double-Spin Prepared Platelet-Rich Plasma Injection in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor

research Comparison between single- versus double-spin prepared platelet-rich plasma injection in treatment of female pattern hair loss: clinical effect and relation to vascular endothelial growth factor

10 citations , September 2020 in “Archives of Dermatological Research”

Both methods improve hair density and thickness; double-spin may be more effective.

research Finasteride Reduces Microvessel Density and Expression of Vascular Endothelial Growth Factor in Renal Tissue of Diabetic Rats

7 citations , March 2015 in “The American Journal of the Medical Sciences”

Finasteride helps reduce blood vessel growth in diabetic rat kidneys.

research Activation of cAMP Signaling in Response to α-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells

6 citations , August 2022 in “International journal of molecular sciences”

α-Phellandrene may help prevent hair loss by increasing growth factors and cell growth in hair cells through a specific signaling pathway.

research Topical tacrolimus suppresses the expression of vascular endothelial growth factor and insulin-like growth factor-1 in late anagen

6 citations , June 2009 in “Clinical and Experimental Dermatology”

Topical tacrolimus reduces certain growth factors in hair follicles.

research Induction of Vascular Endothelial Growth Factor Messenger Ribonucleic Acid Expression in Stored Micrografts by Aminoguanidine

3 citations , November 2005 in “Dermatologic Surgery”

Aminoguanidine increases a specific growth signal in stored hair grafts, which may help them survive better after being transplanted.

research A Split Scalp Study of Single versus Double Spin Platelet-rich plasma Injections in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor in PRP

1 citations , October 2021 in “QJM: An International Journal of Medicine”

Double-spin PRP is more effective for treating female hair loss than single-spin PRP.

research Unexpected Autocrine Role of Vascular Endothelial Growth Factor in Squamous Cell Carcinoma

1 citations , February 2009 in “Journal of Investigative Dermatology”

VEGF helps squamous cell carcinoma grow in ways beyond just blood vessel formation.