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GlossaryEpidermal Differentiation Genes

regulate skin cell maturation and barrier formation

Epidermal Differentiation Genes are a group of genes that play a crucial role in the development and maturation of the outermost layer of the skin, known as the epidermis. These genes regulate the process by which skin cells (keratinocytes) mature, form protective barriers, and eventually shed, ensuring the skin remains healthy and functional.

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research Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex

77 citations , April 2005 in “Journal of Investigative Dermatology”

Repetin is a protein involved in skin and hair development, binding calcium and compensating for other proteins when needed.

research 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

TET enzymes are important for skin and hair development by controlling gene activity in specific areas.

research Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation

19 citations , September 2007 in “The Journal of Steroid Biochemistry and Molecular Biology”

Glucocorticoid receptors help regulate genes important for skin health and hair growth.

2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

86 citations , August 2011 in “Toxicological sciences”

TCDD speeds up skin barrier formation by increasing certain gene expressions.

research Epidermal Dysplasia and Abnormal Hair Follicles in Transgenic Mice Overexpressing Homeobox Gene MSX-2

49 citations , August 1999 in “Journal of Investigative Dermatology”

Overexpressing the MSX-2 gene in mice causes skin and hair growth issues.

Chromatin Remodeler Lymphoid-Specific Helicase (Lsh) Is a Critical Determinant Controlling Postnatal Epidermal Growth, Differentiation, and Response to Injury

research 707 Chromatin remodeler Lymphoid-specific helicase (Lsh) is a critical determinant controlling postnatal epidermal growth, differentiation and response to injury

April 2016 in “Journal of Investigative Dermatology”

Lymphoid-specific helicase (Lsh) is crucial for skin growth, change, and healing after injury.

research 591 Chromatin architectural protein CTCF regulates terminal keratinocyte differentiation in the developing epidermis and hair follicles

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

CTCF protein is essential for skin and hair follicle development in mice.

research Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets.

39 citations , January 2016 in “PubMed”

Understanding how EDC genes are regulated can help develop better drugs for skin diseases.

research Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia

19 citations , August 2012 in “Cell death and differentiation”

Intu gene is crucial for hair follicle formation by helping keratinocytes differentiate through primary cilia.

research The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function

1 citations , January 2013

Glucosylceramides are essential for healthy skin and proper wound healing.

research 547 CDK9 Kinase Activation in Association with AFF1-SEC Initiate Epidermal Progenitor differentiation

November 2022 in “Journal of Investigative Dermatology”

NCSTN gene mutation causes abnormal skin cell differentiation and more inflammation, contributing to Hidradenitis Suppurativa.

research Hair follicle differentiation: expression, structure and evolutionary conservation of the hair type II keratin intermediate filament gene family

65 citations , February 1992 in “Development”

Type II keratin genes are crucial for hair follicle differentiation and have a conserved structure and expression pattern.

research Expression of the Scube3 epidermal growth factor-related gene during early embryonic development in the mouse

17 citations , December 2006 in “Gene Expression Patterns”

Scube3 gene affects mouse embryo growth in multiple areas, but needs more research.

research Chapter 3 Expression and Modification of Keratins During Terminal Differentiation of Mammalian Epidermis

81 citations , January 1987 in “Current topics in developmental biology/Current Topics in Developmental Biology”

Keratins change and are modified differently in skin layers and body parts.

research Loss of ERBB2 and ERBB3 Receptors Impacts Epidermal Differentiation in Mice

July 2024 in “Journal of Investigative Dermatology”

Losing both ERBB2 and ERBB3 receptors in mice causes significant skin problems and inflammation.

Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

research Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

69 citations , August 1999 in “Developmental biology”

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

research A 4kb Fragment of the Desmocollin 3 Promoter Directs Reporter Gene Expression to Parakeratotic Epidermis and Primary Hair Follicles

1 citations , July 2006 in “Journal of Investigative Dermatology”

A 4kb fragment of the desmocollin 3 promoter targets gene expression to specific skin and hair follicle areas.

research Human Epidermal Neural Crest Stem Cells (hEPI-NCSC)—Characterization and Directed Differentiation into Osteocytes and Melanocytes

91 citations , March 2011 in “Stem Cell Reviews and Reports”

Human epidermal neural crest stem cells can become bone and skin pigment cells, making them useful for therapies.

The Early Region of Trichodysplasia Spinulosa Polyomavirus Drives Proliferation, Altered Differentiation, and Ectopic Expression of Hair Follicle Differentiation Markers in Interfollicular Tail Epidermis

research LB1019 The early region of trichodysplasia spinulosa polyomavirus drives proliferation, altered differentiation, and ectopic expression of hair follicle differentiation markers in interfollicular tail epidermis

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

The early genes of a specific virus can cause abnormal skin cell growth and hair follicle changes.

research Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations

41 citations , December 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

Deleting MED1 in skin cells causes hair loss and skin changes.

research Author response: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ

March 2017

Loss of Dnmt3a and Dnmt3b leads to more aggressive skin tumors, but blocking PPAR-γ can reduce this effect.

research The nude gene and the skin

41 citations , October 2001 in “Experimental Dermatology”

The nude gene is important for skin and hair development.

research Decision letter: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ

November 2016

Loss of Dnmt3a and Dnmt3b increases aggressive skin tumors by affecting PPAR-γ.

research The Proximal Promoter of the Human Transglutaminase 3 Gene

105 citations , February 1996 in “Journal of biological chemistry/The Journal of biological chemistry”

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

research Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation

79 citations , December 1999 in “Mechanisms of Development”

Whn is crucial for hair growth in certain areas by controlling a specific gene.

research Isolation and Characterization of a Putative Keratin-Associated Protein Gene Expressed in Embryonic Skin of Mice

22 citations , July 1998 in “Journal of Investigative Dermatology”

The 4C32 gene may help in mouse skin development and differentiation.

research Le gènehairlessde la souris

4 citations , May 2006 in “médecine/sciences”

The hairless gene is crucial for hair health, and its mutations cause hair loss.

research MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters

1 citations , July 2023 in “Nature communications”

MOF controls key genes for skin development by regulating mitochondrial and ciliary functions.

research Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin

555 citations , July 2001 in “Genes & Development”

Tcf3 and Lef1 are key in deciding skin stem cell roles.

research Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium

56 citations , July 2004 in “Mechanisms of Development”

Pax9 is crucial for proper tongue surface development and preventing skin-like changes.