72 citations
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November 2002 in “Journal of Investigative Dermatology” Estrogen receptor α controls hair growth cycles and skin thickness in male mice.
69 citations
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August 1999 in “Developmental biology” The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.
62 citations
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July 1993 in “Journal of Investigative Dermatology” Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.
56 citations
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December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair follicle cells age faster and lose pigment due to less catalase, causing hair to turn gray.
48 citations
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January 2018 in “Stem Cells International” Skin-derived stem cells show promise for improving wound healing and creating transplantable tissue.
46 citations
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December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Disrupting Acvr1b in mice causes severe hair loss and thicker skin.
45 citations
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July 2009 in “Journal of Investigative Dermatology” The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.
43 citations
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January 2012 in “Biological Research” The origins of many adult skin stem cells are still mostly unknown.
42 citations
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July 2017 in “Molecular therapy” A form of vitamin E promotes hair growth by activating a specific skin pathway.
42 citations
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October 2006 in “Theriogenology” Porcine skin cells are useful for studying wound healing and cancer.
41 citations
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January 2015 in “Development” Atoh1 expression can create new Merkel cells in the skin.
39 citations
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January 2013 in “Journal of Investigative Dermatology” Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.
39 citations
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March 2009 in “Dermatology Online Journal” Understanding EGFR roles could lead to new hair loss treatments.
30 citations
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April 2020 in “Stem Cell Research & Therapy” PI3K/Akt pathway is crucial for hair growth and regeneration.
29 citations
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September 2017 in “Oncology and therapy” The document provides advice on how to recognize and treat skin-related side effects of cancer drugs known as EGFR inhibitors.
29 citations
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October 2010 in “Journal of Investigative Dermatology” Activating Kras in mouse skin causes excess skin and hair loss.
28 citations
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September 2015 in “Wiener Klinische Wochenschrift” New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.
27 citations
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May 2007 in “Archives of dermatological research” Diphencyprone treatment increases CD8 lymphocytes in the scalp, which is associated with hair regrowth in alopecia areata patients.
23 citations
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August 2018 in “Facial Plastic Surgery Clinics of North America” Using defensins to activate stem cells may improve skin aging signs without causing inflammation.
22 citations
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August 2013 in “Experimental Dermatology” EGFR hyperactivation increases sebaceous gland size and sebum production in mice.
19 citations
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January 2007 in “Journal of medical investigation” GFP transgenic mice help study cell origins in skin grafts.
18 citations
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January 2013 in “Journal of Investigative Dermatology” WIF1 helps keep skin stem cells inactive to prevent excessive cell growth.
13 citations
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March 2022 in “Cell Death and Differentiation” Sema3A can both slow and speed up wound healing, depending on its form and combination with EGF.
13 citations
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January 2018 in “Cellular Physiology and Biochemistry” Fat-derived stem cells can help protect and repair skin stem cells from aging caused by UV light.
12 citations
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May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” Laminin 332 is essential for normal skin cell behavior and structure.
10 citations
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September 2018 in “Regenerative Medicine” New hair can grow from large wounds in mice, but less so as they age, involving reprogramming of skin cells and specific molecular pathways.
8 citations
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February 2020 in “Journal of Drug Delivery Science and Technology” Encapsulating chlorogenic acid in nanoparticles boosts type 17 collagen production, potentially aiding skin care.
7 citations
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January 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” Skin cells control immune cell placement, helping the skin respond better to challenges.
7 citations
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October 2018 in “BMC genomics” Key genes can rewire networks, changing skin appendage types.
6 citations
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July 2023 in “Nature cell biology” SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.