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GlossaryEpidermal Growth Factor Receptor

protein on cell surfaces aiding growth and division

The Epidermal Growth Factor Receptor (EGFR) is a protein found on the surface of cells that helps them grow and divide. It is crucial in regulating cell growth, survival, and differentiation. When EGFR is mutated or overexpressed, it can lead to uncontrolled cell proliferation, which is a common feature in various cancers.

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research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

research The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors

18 citations , January 2017 in “Postępy Dermatologii i Alergologii”

EGFR inhibitors can cause various skin issues during cancer treatment, and managing these is important for patient care.

research Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor

169 citations , September 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

ZD1839 (Iressa) causes skin and hair side effects, treatable with tretinoin cream and minocycline.

research Cutaneous consequences of inhibiting EGF receptor signaling in vivo: Normal hair follicle development, but retarded hair cycle induction and inhibition of adipocyte growth in EgfrWa5 mice

32 citations , January 2010 in “Journal of Dermatological Science”

Reduced EGFR signaling delays hair cycle and reduces fat growth, but hair development remains normal.

research Syntaxin 9 is Enriched in Skin Hair Follicle Epithelium and Interacts With the Epidermal Growth Factor Receptor

13 citations , December 2005 in “Traffic”

Syntaxin 9 helps in transporting and signaling of the EGF receptor in skin and stomach cells.

research Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development

25 citations , September 2018 in “Molecular Biology of the Cell”

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

research KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin

82 citations , May 2009 in “Development”

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

research The Cutaneous Epidermal Growth Factor Network: Can it be Translated Clinically to Stimulate Hair Growth? - eScholarship

March 2009 in “Dermatology Online Journal”

Manipulating EGFR signaling may help treat hair loss and promote hair growth.

research Role for the Epidermal Growth Factor Receptor in Chemotherapy-Induced Alopecia

20 citations , July 2013 in “PLoS ONE”

Targeting EGFR may help reduce hair loss from chemotherapy.

research 546 Epidermal growth factor receptor as a key regulator of the immune privilege

November 2022 in “Journal of Investigative Dermatology”

EGFR is crucial for preventing hair follicle inflammation and hair loss.

research Nonscarring inflammatory alopecia associated with the epidermal growth factor receptor inhibitor gefitinib

57 citations , August 2006 in “Journal of the American Academy of Dermatology”

Gefitinib can cause hair loss without scarring.

research Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation

97 citations , June 2013 in “Journal of Dermatological Science”

Understanding EGFR's role in skin is crucial for better treatments and managing side effects.

Beta-Catenin–Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding

research β-Catenin–Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding [RETRACTED]

13 citations , February 2018 in “Plastic and Reconstructive Surgery”

The study found that a specific signaling pathway helps skin wounds heal faster but may lead to larger scars.

research Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair

10 citations , July 2019 in “Advances in Wound Care”

Reducing Flightless I protein improves wound healing by activating skin stem cells.

research Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling?

19 citations , September 2008 in “Journal of Cellular Physiology”

Blocking EGFR can cause skin inflammation by disrupting IL-1 signaling.

research Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice.

114 citations , July 2003 in “PubMed”

Lack of KSR1 stops certain skin tumors in mice.

research VEGF upregulates VEGF receptor-2 on human outer root sheath cells and stimulates proliferation through ERK pathway

23 citations , June 2012 in “Molecular Biology Reports”

VEGF stimulates hair cell growth and increases growth receptor levels through a specific signaling pathway.

A Desmosomal Cadherin Controls Multipotent Hair Follicle Stem Cell Quiescence and Orchestrates Regeneration Through Adhesion Signaling

research A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling

1 citations , November 2023 in “iScience”

A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.

research Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells

1 citations , January 2022 in “BMC Genomic Data”

The study found that androgen receptors in skin cells mainly affect the focal adhesion pathway and control the caveolin-1 gene, with implications for new treatments for related diseases.

research MLPH-mediated activation of dermal papilla IGF-1 signaling drives human hair shaft elongation and anagen induction

February 2026 in “Biomedicine & Pharmacotherapy”

MLPH helps hair grow by activating IGF-1 signaling in hair cells.

research 870 Y27632 promotes proliferation via EGFR signaling in a newly isolated and characterized human primary sebocyte cell line

April 2019 in “Journal of Investigative Dermatology”

Y27632 increases cell growth through EGFR signaling, not ROCK1/2.

research Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways

1 citations , December 2023 in “Animals”

Winter provides the best fur quality for Rex rabbits due to seasonal changes in specific signaling pathways.

research Cutaneous Side Effects in Non-Small Cell Lung Cancer Patients Treated with Iressa (ZD1839), an Inhibitor of Epidermal Growth Factor

116 citations , December 2003 in “Acta Dermato Venereologica”

Iressa often causes skin issues like acne and dryness in lung cancer patients.

research The Cutaneous Epidermal Growth Factor Network: Can it be Translated Clinically to Stimulate Hair Growth?

39 citations , March 2009 in “Dermatology Online Journal”

Understanding EGFR roles could lead to new hair loss treatments.

research The Epithelial Stem Cell Niche in Skin

9 citations , January 2017 in “Elsevier eBooks”

Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.

research Hair follicle stem cells and the collapse of self-tolerance in alopecia: the interplay of barrier function, the microbiome, and immunity

November 2024 in “EMBO Molecular Medicine”

JAK inhibitors may reverse early hair loss, but prolonged inflammation can cause permanent hair loss.