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GlossaryEpidermal Growth Factor

stimulates cell growth and healing in skin and hair

Epidermal Growth Factor (EGF) is a protein that stimulates cell growth, proliferation, and differentiation by binding to its receptor, EGFR. It plays a crucial role in the healing of wounds and the regeneration of skin and hair follicles. EGF is often used in skincare products to promote skin repair and reduce signs of aging.

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research Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

252 citations , November 1995 in “The EMBO Journal”

Blocking EGFR in mice causes hair loss and skin changes.

research Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes

226 citations , August 2006 in “Molecular and Cellular Biology”

EGF signaling affects gene expression in skin cells, influencing hair growth and potentially cancer.

research Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor

169 citations , September 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

ZD1839 (Iressa) causes skin and hair side effects, treatable with tretinoin cream and minocycline.

research Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.

164 citations , December 1984 in “Proceedings of the National Academy of Sciences”

TCDD reduces EGF receptor activity and causes various developmental changes in animals.

Classification and Management of Skin, Hair, Nail, and Mucosal Side Effects of Epidermal Growth Factor Receptor Inhibitors

research Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors

138 citations , February 2007 in “European journal of cancer”

EGFR inhibitors often cause skin problems and other side effects, but these are usually reversible and can be managed to keep patients comfortable.

research Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth

124 citations , December 1983 in “Developmental Biology”

EGF receptors are crucial for skin cell growth and decrease with age.

research Cutaneous Side Effects in Non-Small Cell Lung Cancer Patients Treated with Iressa (ZD1839), an Inhibitor of Epidermal Growth Factor

116 citations , December 2003 in “Acta Dermato Venereologica”

Iressa often causes skin issues like acne and dryness in lung cancer patients.

research Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development.

107 citations , June 1997 in “PubMed”

EGFR is essential for normal hair development and follicle differentiation.

research Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation

97 citations , June 2013 in “Journal of Dermatological Science”

Understanding EGFR's role in skin is crucial for better treatments and managing side effects.

research Epidermal Growth Factor as a Biologic Switch in Hair Growth Cycle

94 citations , July 2003 in “Journal of biological chemistry/The Journal of biological chemistry”

EGF controls hair growth by regulating hair follicles' growth phases.

research The PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) syndrome

90 citations , August 2006 in “British Journal of Dermatology”

PRIDE syndrome includes skin and hair issues from cancer treatment with EGFR inhibitors.

research EFFECTS OF EPIDERMAL GROWTH FACTOR ON HAIR GROWTH IN THE MOUSE

84 citations , February 1981 in “Journal of Endocrinology”

Epidermal growth factor slows hair and body growth in mice.

research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

research Epidermal growth factor delays the development of the epidermis and hair follicles of mice during growth of the first coat

72 citations , January 1983 in “The Anatomical Record”

Epidermal growth factor delays skin and hair development in mice.

research Epidermal Growth Factor Receptor Inhibitors: A Review of Cutaneous Adverse Events and Management

68 citations , January 2014 in “Dermatology research and practice”

Skin side effects from cancer drugs targeting EGFR can affect treatment adherence but can be managed with antibiotics like tetracycline.

research 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane

60 citations , December 1988 in “Journal of Biochemical Toxicology”

TCDD reduces EGF receptors in the liver, affecting growth and development.

Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

research Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro

58 citations , June 1987 in “Archives of Dermatological Research”

EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.

research Nonscarring inflammatory alopecia associated with the epidermal growth factor receptor inhibitor gefitinib

57 citations , August 2006 in “Journal of the American Academy of Dermatology”

Gefitinib can cause hair loss without scarring.

research Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

53 citations , July 2009 in “Cancer Research”

Blocking certain proteins can reduce skin inflammation caused by cancer treatment.

research Aberrant expression of epidermal growth factor receptor in aural cholesteatoma

48 citations , March 1993 in “The Laryngoscope”

Cholesteatoma shows abnormal and increased EGF receptor expression, indicating its rapid growth.

research Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling

43 citations , January 2016 in “Cellular physiology and biochemistry”

Epidermal Growth Factor helps hair follicle cells grow and move by activating a specific cell signaling pathway.

research Effects of Intradermally Injected and Topically Applied Mouse Epidermal Growth Factor on Wool Growth, Skin and Wool Follicles of Merino Sheep

36 citations , June 1988 in “Australian Journal of Biological Sciences”

Mouse epidermal growth factor injections in sheep affected wool growth and skin, but saline did not.

research Epidermal Growth Factor Upregulates Production of Supernumerary Hair Cells in Neonatal Rat Organ of Corti Explants

33 citations , January 2000 in “Acta Oto-Laryngologica”

Epidermal growth factor increases extra hair cells in newborn rat ears.

research A case report of inflammatory nonscarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib

33 citations , June 2009 in “Journal of Cutaneous Pathology”

Erlotinib can cause nonscarring hair loss and itchy skin.

Neutralization of IL-8 Prevents Dermatologic Adverse Events Associated with Epidermal Growth Factor Receptor Inhibition

research Neutralization of IL-8 Prevents the Induction of Dermatologic Adverse Events Associated with the Inhibition of Epidermal Growth Factor Receptor

32 citations , June 2012 in “PLoS ONE”

Blocking IL-8 can reduce skin rashes from cancer treatment.