April 2024 in “Communications biology” Enzymes involved in Vitamin A metabolism affect hair growth and type in mice.
May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.
Proretinal nanoparticles are a safe and effective way to deliver retinal to the skin.
March 2009 in “Dermatology Online Journal” Manipulating EGFR signaling may help treat hair loss and promote hair growth.
1010 citations
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August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
788 citations
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February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
759 citations
,
February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
555 citations
,
July 2001 in “Genes & Development” Tcf3 and Lef1 are key in deciding skin stem cell roles.
503 citations
,
May 2009 in “Cell stem cell” Lrig1 marks a unique group of stem cells in mouse skin that can become different skin cell types.
414 citations
,
August 2005 in “Nature” Activating TERT in mice skin boosts hair growth by waking up hair follicle stem cells.
401 citations
,
January 2013 in “Postepy Dermatologii I Alergologii” The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.
380 citations
,
March 2000 in “Proceedings of the National Academy of Sciences” Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.
375 citations
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February 2006 in “Journal of Cell Science” The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
354 citations
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February 2011 in “Genes & Development” EZH1 and EZH2 are crucial for healthy hair growth and skin repair.
338 citations
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July 2009 in “Development” Sox2-positive cells determine specific hair follicle types in mammals.
333 citations
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March 2000 in “Proceedings of the National Academy of Sciences” Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.
300 citations
,
August 2012 in “Seminars in Cell & Developmental Biology” The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.
277 citations
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February 2013 in “Science Signaling” Mitochondrial reactive oxygen species are essential for skin and hair development.
253 citations
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March 1994 in “Developmental dynamics” Apoptosis is essential for human skin development and forming a functional epidermis.
232 citations
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October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.
232 citations
,
January 2013 in “Nature Cell Biology” Understanding where cancer cells come from helps create better prevention and treatment methods.
218 citations
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April 2008 in “Genes & Development” Skin stem cells help repair damage and maintain healthy skin.
211 citations
,
November 2018 in “Nature Cell Biology” Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.
211 citations
,
May 2018 in “Trends in cell biology” Different types of skin cells play specific roles in development, healing, and cancer.
195 citations
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January 2008 in “Photochemistry and Photobiology” Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.
195 citations
,
November 2001 in “The Journal of Cell Biology” Desmocollin 1 is essential for strong skin and proper skin function.
192 citations
,
January 2015 in “Journal of the American Academy of Dermatology” Targeted cancer therapies often cause serious skin problems that need careful management.
184 citations
,
September 2006 in “PLoS Genetics” The Apc gene is crucial for normal skin and thymus development.
183 citations
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January 2014 in “BioMed Research International” AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.
182 citations
,
May 2003 in “Development” Myc activation reduces skin stem cells by affecting cell adhesion.