192 citations
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January 2015 in “Journal of the American Academy of Dermatology” Targeted cancer therapies often cause serious skin problems that need careful management.
133 citations
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May 2016 in “Cell Host & Microbe” Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.
129 citations
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May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
128 citations
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October 2011 in “Development” Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.
113 citations
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September 2005 in “Journal of Investigative Dermatology” Applying a special compound can promote hair growth without harmful side effects.
111 citations
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August 1998 in “Journal of Investigative Dermatology” μ-opiate receptors in skin cells may affect skin health and healing.
108 citations
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January 2003 in “Journal of Cosmetic Dermatology” Wrinkles form due to structural skin changes and vary in type and treatment response.
101 citations
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August 2010 in “PLoS ONE” Selenoproteins are crucial for healthy skin and hair.
94 citations
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February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
90 citations
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October 1996 in “Dermatologic Clinics” Growth factors are crucial for hair development and could help treat hair diseases.
81 citations
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September 2009 in “Birth defects research” Different body areas in mice produce different hair types due to interactions between skin layers.
74 citations
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June 2018 in “Cell death and disease” Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.
72 citations
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November 2017 in “Journal of developmental biology” The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
68 citations
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December 1991 in “Annals of the New York Academy of Sciences” Hair growth can be induced by certain cells found at the base of hair follicles, and these cells may also influence hair development and regeneration.
57 citations
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February 1994 in “Experimental dermatology” Melatonin affects mouse skin and may regulate skin functions.
50 citations
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December 2020 in “Bioactive Materials” Wound dressing absorbs fluid, regenerates hair follicles, and heals skin burns.
44 citations
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December 1991 in “Annals of the New York Academy of Sciences” EGF and FGF help hair growth by affecting cell differentiation and fiber growth.
43 citations
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October 2013 in “Journal of Investigative Dermatology” Organotypic culture systems can grow skin tissues that mimic real skin functions and are useful for skin disease and hair growth research, but they don't fully replicate skin complexity.
43 citations
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January 2012 in “Biological Research” The origins of many adult skin stem cells are still mostly unknown.
41 citations
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December 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” Deleting MED1 in skin cells causes hair loss and skin changes.
39 citations
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September 2007 in “BMC developmental biology” Neuregulin3 affects cell development in the skin and mammary glands.
37 citations
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July 2016 in “Current Opinion in Cell Biology” Live imaging has advanced our understanding of stem cell behavior and raised new research questions.
36 citations
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May 2016 in “Biomaterials” Endo-HSE helps grow hair-like structures from human skin cells in the lab.
36 citations
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March 2011 in “Nature Communications” Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.
28 citations
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March 2017 in “Endocrinology” Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.
25 citations
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March 2012 in “Journal of Dermatological Science” Genetic variants linked to ten skin diseases were found, showing both immune and non-immune factors play a role.
24 citations
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April 2012 in “Developmental Biology” Dermal papillae cells, important for hair growth, come from multiple cell lines and can be formed by skin cells, regardless of their origin or hair cycle phase. These cells rarely divide, but their ability to shape tissue may contribute to their efficiency in inducing hair growth.
23 citations
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June 2012 in “Molecular Biology Reports” VEGF stimulates hair cell growth and increases growth receptor levels through a specific signaling pathway.
23 citations
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March 2010 in “Medical hypotheses” Merkel cells may have roles in sensing magnetic fields, creating fingerprints, Reiki energy healing, passing on environmental information to offspring, and influencing hair shape.
18 citations
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January 2018 in “International journal of medical sciences” Non-thermal plasma treatment makes mouse skin thicker and increases growth factors without harming the tissue.