253 citations
,
March 1994 in “Developmental dynamics” Apoptosis is essential for human skin development and forming a functional epidermis.
165 citations
,
June 2007 in “European Journal of Cell Biology” Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.
87 citations
,
January 2017 in “PLoS Genetics” Removing both KLK5 and KLK7 proteins can prevent death and skin issues in Netherton syndrome.
67 citations
,
December 2019 in “PloS one” Beta-caryophyllene helps improve wound healing in mice, especially in females.
50 citations
,
January 2016 in “The FEBS journal” RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.
43 citations
,
January 2011 in “Plastic and Reconstructive Surgery” Stem cells have great potential for improving wound healing, but more research is needed to find the best types and ways to use them.
40 citations
,
January 1994 in “Skin Pharmacology and Physiology” Male hormones affect oil-producing skin cells differently based on their body location, and the drug spironolactone can reduce these effects.
39 citations
,
July 2021 in “Stem Cell Research & Therapy” Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.
37 citations
,
July 2016 in “Current Opinion in Cell Biology” Live imaging has advanced our understanding of stem cell behavior and raised new research questions.
34 citations
,
June 2008 in “In vitro cellular & developmental biology. Animal” Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.
32 citations
,
March 2014 in “PLOS ONE” Mice lacking fibromodulin have disrupted healing patterns, leading to abnormal skin repair and scarring.
31 citations
,
February 2019 in “International Journal of Cosmetic Science” Caffeine applied to the scalp can protect hair follicles from UV damage.
28 citations
,
March 2010 in “Histochemistry and cell biology” Skin cells can help create early hair-like structures in lab cultures.
26 citations
,
January 2014 in “Cell Structure and Function” Human sweat glands contain stem cells capable of self-renewal and forming different cell types.
22 citations
,
December 2013 in “Molecular biology of the cell” ILK is essential for proper hair follicle development and structure.
19 citations
,
April 2015 in “Developmental Dynamics” The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.
15 citations
,
January 2012 in “Journal of Veterinary Science” Different dog breeds have varying skin thickness and protein expression in their skin.
15 citations
,
December 2014 in “PLoS ONE” A mutation in the iRhom2 gene causes hairless mice due to abnormal hair follicle development.
13 citations
,
January 2022 in “Stem cell reviews and reports” Mouse stem cells from hair follicles can improve wound healing and reduce scarring.
13 citations
,
December 2020 in “Dermatologic Therapy” Sebaceous glands in our skin, developing during pregnancy and active in puberty, produce sebum for skin lubrication, temperature control, and fighting germs, also help in hormone regulation, and their dysfunction can cause conditions like acne and hair loss.
12 citations
,
June 2018 in “Journal of Cosmetic Dermatology” PRP is effective for hair loss and might work better with other treatments, but more research is needed.
12 citations
,
July 2021 in “Scientific Reports” Glutamic acid helps increase hair growth in mice.
11 citations
,
January 2012 in “Journal of cell science” Rac1 is essential for proper hair structure and color.
10 citations
,
May 2018 in “Cell death discovery” HSP90 and lamin A/C are crucial for hair growth and could be targets for treating hair loss.
9 citations
,
July 2020 in “Experimental Dermatology” Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.
9 citations
,
March 2015 in “International reviews of immunology” Skin abnormalities can indicate immunodeficiency due to shared origins with the immune system.
7 citations
,
April 2018 in “Molecular Medicine Reports” BeauTop helps hair grow by increasing certain growth factors.
6 citations
,
August 2019 in “PLOS ONE” Gambogic Amide helps maintain hair color and promotes hair growth.
6 citations
,
February 2012 in “American Journal of Animal and Veterinary Sciences” Growth factors are crucial for hair follicle growth and development.
4 citations
,
November 2014 The skin protects the body, regulates temperature, senses touch, and makes vitamin D.