research JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
JunB is crucial for maintaining healthy skin and hair follicles.
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210-240 / 1000+ results research Outer root sheath (ORS) cells organize into epidermoid cyst-like spheroids when cultured inside Matrigel: a light-microscopic and immunohistological comparison between human ORS cells and interfollicular keratinocytes
research Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells
Combining letrozole and quercetin in spanlastics may improve breast cancer treatment.
research WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation
WIF1 helps keep skin stem cells inactive to prevent excessive cell growth.
research The E6/E7 oncogenes of human papilloma virus and estradiol regulate hedgehog signaling activity in a murine model of cervical cancer
HPV genes and estradiol increase a cancer-related signaling pathway, which may be targeted for cervical cancer treatment.
research Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis
Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.
research Cell cycle controls long-range calcium signaling in the regenerating epidermis
Calcium signaling in skin cells is crucial for communication and regeneration.
research Cutaneous Side Effects in Non-Small Cell Lung Cancer Patients Treated with Iressa (ZD1839), an Inhibitor of Epidermal Growth Factor
Iressa often causes skin issues like acne and dryness in lung cancer patients.
research Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis
Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.
research TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis
TCF/Lef1 activity is essential for proper skin cell development and renewal.
research Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance
Repurposing existing drugs and using micronutrients may effectively target cancer stem cells and improve cancer treatment.
research Transcription Regulation and Protein Subcellular Localization of the Truncated Basic Hair Keratin hHb1-ΔN in Human Breast Cancer Cells
A truncated protein linked to breast cancer may change cell adhesion.
research Bikunin, a Serine Protease Inhibitor, is Present on the Cell Boundary of Epidermis
Bikunin is found on the cell boundaries of certain skin layers and may help regulate skin and hair functions.
research Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis
research FOXE1, A New Transcriptional Target of GLI2 Is Expressed in Human Epidermis and Basal Cell Carcinoma
research Discrimination between basal cell carcinoma and hair follicles in skin tissue sections by Raman micro-spectroscopy
Raman micro-spectroscopy can help distinguish basal cell carcinoma from hair follicles in skin tissue.
research Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation
Understanding how certain proteins and genetic changes control skin stem cells is key to treating skin diseases.
research Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment
Myc activation reduces skin stem cells by affecting cell adhesion.
research Skin melanocytes: biology and development
The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.
research Wnt Signaling Across Adult Skin Mini-Organs: Interfollicular Epidermis, Hair Follicle, and Nail—Implications for Disease and Regeneration
Wnt signaling is crucial for skin, hair, and nail health and regeneration.
research Melanocytes: The new Black
Melanocytes are crucial for skin pigmentation and can affect conditions like melanoma, vitiligo, and albinism, as well as hair color and hearing.
research Adam10 haploinsufficiency causes freckle-like macules in Hairless mice
A mutation in the Adam10 gene causes freckle-like spots on Hairless mice.
research The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters
The type of tumor suppressor gene lost affects the behavior of skin cancer.
research Models for Skin Cancer
Malignant melanoma is the deadliest skin cancer, while BCC is the most common but rarely spreads, and SCC is more aggressive than BCC.
research Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus
The Apc gene is crucial for normal skin and thymus development.
research Smoking and the skin
Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.
research Loss of ‘Epidermal Melanin Unit’ Integrity in Human Skin During Melanoma-Genesis
Melanoma development can be linked to the breakdown of skin's melanin-producing units.
research Fondation René Touraine
The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.
research Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia
The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.
research Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures
A new 3D culture system helps grow and study mouse skin stem cells for a long time.