Transplanting cultured skin sheets improved acne scars in four patients.
Hair follicle-derived sheets can effectively treat vitiligo by repigmenting skin.
March 2019 in “Dermatologic Surgery” 92 citations
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April 1999 in “The journal of investigative dermatology/Journal of investigative dermatology” Nonpalmoplantar skin cells can be made to express keratin 9 by interacting with palmoplantar fibroblasts.
4 citations
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May 2012 in “Tissue Engineering and Regenerative Medicine” Scientists created three types of structures to help regrow hair follicles, and all showed promising results for hair regeneration.
162 citations
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December 2008 in “Stem Cells” Hair follicle stem cells can become corneal-like cells, potentially helping restore vision.
January 2012 in “조직공학과 재생의학” The study found that certain three-dimensional scaffolds can help regenerate hair effectively.
1 citations
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June 2024 in “PLoS ONE” HAP-cell-sheets improved wound healing in diabetic mice.
4 citations
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March 2021 in “Journal of Histotechnology” Hidradenitis suppurativa lesions have less collagen and elastin but more new blood vessels.
Cellular flows and tissue mechanics guide feather follicle formation in birds.
28 citations
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September 2015 in “Wiener Klinische Wochenschrift” New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.
September 2008 in “Acta Ophthalmologica” Hair follicle stem cells can become corneal-like cells with the right environment.
May 2020 in “Research Square (Research Square)” Human stem cells can turn into functional eye cells that might help treat retinal diseases.
40 citations
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March 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Growing hair follicles have high mitochondrial activity and ROS in specific regions, aiding hair formation.
11 citations
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January 2013 in “Veterinary dermatology” Keratinocytes from dog hair follicles can create a functional skin layer in a lab model, useful for dog skin therapy.
February 2026 in “American Journal Of Pathology” Skin organoids can mimic human skin responses to injury and inflammation, making them useful for studying skin diseases and testing treatments.
May 2023 in “Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ” High doses of rosemary extract can harm the liver, kidneys, and reproductive organs in young rats.
508 citations
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February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
129 citations
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May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
1 citations
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January 2019 in “Elsevier eBooks” Electrospun matrices help regenerate skin and hair follicles using PCL and collagen scaffolds.
January 2007 in “The Year book of surgery” Mast cells and VEGF contribute to post-surgery adhesions, and blocking VEGF can reduce these adhesions; also, certain factors affect wound healing and fetal skin heals differently with age.
August 2018 in “Journal of Investigative Dermatology” The conclusion is that using light-sheet fluorescence microscopy with a special solution can effectively create detailed 3D images of human skin for dermatological research.
260 citations
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June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
82 citations
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February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
8 citations
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November 2020 in “Nature Communications” Adult stem cells with Tp63 can form hair and skin cells when placed in new skin, showing they have hidden abilities for skin repair.
4 citations
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May 2014 in “Biochemical Society Transactions” Environmental cues can change the fate and function of epithelial cells, with potential for cell therapy.
170 citations
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July 2012 in “Journal of Investigative Dermatology” Wnt ligands are crucial for hair growth and repair.
114 citations
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December 1951 in “Archives of Dermatology” Aminopterin strongly suppresses epithelial tissues and can treat certain skin conditions but has significant side effects.
19 citations
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March 2017 in “PLoS ONE” PSU are better than THF at regenerating skin layers in lab models.
3 citations
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June 1983 in “Archives of Dermatology” Aminopterin effectively improves skin conditions but has toxic side effects that need careful monitoring.