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GlossaryERK inhibitors

drugs that block proteins involved in cell signaling

ERK inhibitors are drugs or molecules that block the activity of ERK (Extracellular signal-Regulated Kinases), which are proteins involved in sending signals within cells. These signals can control various functions, including cell growth and division. By inhibiting ERK, these drugs can potentially treat conditions like cancer, where cell growth is uncontrolled, or even certain types of hair loss by affecting the pathways that regulate hair follicle activity.

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research The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation

15 citations , March 2015 in “Experimental Dermatology”

Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.

research VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK

120 citations , May 2012 in “Experimental Cell Research”

VEGF promotes hair follicle cell growth through the VEGFR-2/ERK pathway.

research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations , March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

research Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells

July 2024 in “International Journal of Molecular Sciences”

The inhibitor DPP can promote hair growth.

research The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors

18 citations , January 2017 in “Postępy Dermatologii i Alergologii”

EGFR inhibitors can cause various skin issues during cancer treatment, and managing these is important for patient care.

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-α Production in LPS-Activated Macrophages via Suppression of NF-κB

54 citations , June 2008 in “Planta Medica”

Hinokitiol may help treat hair loss by reducing inflammation and promoting hair growth.

research Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling

8 citations , June 2022 in “Frontiers in bioengineering and biotechnology”

A patch made from human lung fibroblast material helps heal skin wounds effectively, including diabetic ulcers.

research Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor

33 citations , January 2015 in “Journal of Ginseng Research”

Ginsenoside Rg3 from Panax ginseng can lighten skin by reducing melanin production.

research 873 The effect of Cilostazol on hair growth: A novel therapeutic option for the treatment of hair loss

1 citations , April 2017 in “Journal of Investigative Dermatology”

Cilostazol may help hair grow and could be a new treatment for hair loss.

research Cutaneous Drug Eruptions Associated with the Use of New Oncological Drugs

29 citations , January 2012 in “Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy”

New cancer drugs often cause skin and nail problems.

research 691 Topical curcumin promotes induction of the murine hair cycle

3 citations , April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Curcumin applied to the skin can start hair growth in mice.

research 546 Epidermal growth factor receptor as a key regulator of the immune privilege

November 2022 in “Journal of Investigative Dermatology”

EGFR is crucial for preventing hair follicle inflammation and hair loss.

research When bugs and drugs conspire: driving acneiform skin toxicity

1 citations , February 2020 in “The Journal of clinical investigation/The journal of clinical investigation”

Certain cancer drugs interact with skin bacteria to cause acne-like rashes.

research Sorafenib-induced eruption resembling pityriasis rubra pilaris

21 citations , July 2011 in “Journal of the American Academy of Dermatology”

A man developed a rash similar to pityriasis rubra pilaris after starting sorafenib for cancer, possibly due to the drug's effect on skin cells.

research Cutaneous adverse effects of targeted therapies

149 citations , January 2015 in “Journal of the American Academy of Dermatology”

Targeted cancer therapies often cause skin side effects, needing dermatologist care.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

Preconditioning With Far-Infrared Irradiation Enhances Proliferation, Cell Survival, And Migration Of Rat Bone Marrow-Derived Stem Cells Via CXCR4-ERK Pathways

research Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways

44 citations , October 2017 in “Scientific Reports”

Far-infrared radiation improves stem cell growth and movement, helping heart therapy.

research Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias

10 citations , December 2018 in “Medical Science Monitor”

The MAPK/ERK pathway is crucial in controlling cell growth and death in finasteride-induced hypospadias.

research Wheat Sprout Extract Stimulates Cell Proliferation via Phosphorylation of ERK and Akt in Human Dermal Papilla Cells

June 2017 in “Yakakoeji/Yaghag hoeji”

Wheat sprout extract boosts hair cell growth by activating specific proteins.

Wnt/β-Catenin and ERK Pathway Activation: The Possible Mechanism of Various LED Light Regulating the Proliferation of Human Outer Root Sheath Cells

research Wnt/β-catenin and ERK pathway activation: The possible mechanism of various light-emitting diode light regulates the proliferation of human outer root sheath cells

May 2017 in “Journal of The American Academy of Dermatology”

LED light helps human hair root cells grow and move by activating certain cell pathways.

Bisphenol-A Antagonizes the Rapidly Modulating Effect of Dihydrotestosterone on Spinogenesis and Long-Term Potentiation of Hippocampal Neurons

research Bisphenol-A antagonizes the rapidly modulating effect of DHT on spinogenesis and long-term potentiation of hippocampal neurons

10 citations , December 2017 in “Chemosphere”

Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.

research Effect of Puerariae Radix Ethanol Extract on the Proliferation of Human Dermal Papilla Cells

3 citations , June 2017 in “Journal of Physiology & Pathology in Korean Medicine”

Puerariae Radix extract may help hair growth by increasing cell activity.

research Inhibition of TNF-α-Induced Collagen Degradation and Oxidative Damage by Centipeda minima and Brevilin A in Human Dermal Fibroblasts

1 citations , May 2025 in “Current Issues in Molecular Biology”

Centipeda minima and brevilin A protect skin cells from damage and aging.

research Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades

14 citations , January 2016 in “Biochemical and Biophysical Research Communications”

Ginsenoside Re from ginseng may help hair grow by blocking a specific growth-inhibiting pathway.

research Role of Ornithine Decarboxylase in Human Hair Follicles

1 citations , January 2010

Ornithine decarboxylase is crucial for human hair growth and the hair cycle.