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GlossaryEstrogenic Activity

ability of a substance to mimic or influence estrogen effects

Estrogenic activity refers to the ability of a substance to mimic or influence the effects of estrogen, a primary female sex hormone, in the body. This can impact various biological processes, including reproductive health, bone density, and hair growth. Substances with estrogenic activity can bind to estrogen receptors and trigger similar responses as natural estrogen, which is why they are significant in both medical treatments and environmental health studies.

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research Mechanism of action of bolandiol (19-nortestosterone-3β,17β-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities

11 citations , November 2009 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

research Protective cardiovascular and renal actions of vitamin D and estrogen

13 citations , December 2012 in “Frontiers in bioscience”

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

research Testosterone Prevents Cutaneous Ischemia and Necrosis in Males Through Complementary Estrogenic and Androgenic Actions

12 citations , March 2017 in “Arteriosclerosis, thrombosis, and vascular biology”

Testosterone helps prevent skin damage in males by acting through both estrogen and androgen pathways.

research The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta?

65 citations , May 2006 in “Journal of Investigative Dermatology”

Dexamethasone may influence hair growth by altering estrogen receptor activity in hair cells.

research Cellular actions of testosterone in vascular cells: Mechanism independent of aromatization to estradiol

55 citations , June 2012 in “Steroids”

Testosterone affects vascular cells directly without converting to estradiol.

research Mechanism of action of herbs and their active constituents used in hair loss treatment

47 citations , August 2016 in “Fitoterapia”

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

research The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors

219 citations , January 2006 in “Drug Metabolism Reviews”

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

research 5α‐Reductase Isozymes and Androgen Actions in the Prostate

93 citations , February 2009 in “Annals of the New York Academy of Sciences”

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

research Steroid inhibitors of androgen-potentiated actions on skin

4 citations , July 1983 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry”

Certain hormones can reduce skin oil and hair growth, potentially helping treat acne and excessive hair in women.

research Anti-SARS-CoV-2 Action of 5α-Reductase Inhibitors May Be Mediated by Dehydroepiandrosterone. Letter.

1 citations , February 2022 in “The Journal of Urology”

Certain drugs like Dutasteride and Finasteride might help fight SARS-CoV-2 by increasing levels of a steroid called DHEA, which can protect the heart and increase nitric oxide to counteract the virus.

research Mechanisms of testosterone action

January 2021

Testosterone works in different ways, including direct interaction with its receptor, conversion to other hormones for specific effects on genitalia, hair, bones, and muscle, and changes in body fat and sexual function when low.

research In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach

30 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

research Topical and nutricosmetic products for healthy hair and dermal antiaging using “dual‐acting” (2 for 1) plant‐based peptides, hormones, and cannabinoids

13 citations , May 2021 in “FASEB bioAdvances”

Plant-based products can improve hair and skin health without harmful side effects.

research Gonadal Sex Steroids: Production, Action and Interactions in Mammals

2 citations , November 2012 in “InTech eBooks”

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Nutraceuticals Known to Promote Hair Growth Do Not Interfere With the Inhibitory Action of Tamoxifen in MCF7, T47D and BT483 Breast Cancer Cell Lines

research Nutraceuticals known to promote hair growth do not interfere with the inhibitory action of tamoxifen in MCF7, T47D and BT483 breast cancer cell lines

February 2024 in “PloS one”

Nutraceuticals that promote hair growth do not reduce tamoxifen's effectiveness in breast cancer treatment.

research Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death

34 citations , February 2015 in “Frontiers in Cellular Neuroscience”

Zebrafish helped find new ways to prevent drug-induced hair cell death and potential treatments for hearing loss.

research Nutraceuticals Known To Promote Hair Growth Do Not Interfere With The Inhibitory Action of Tamoxifen In MCF7, T47D And BT483 Breast Cancer Cell Lines

February 2022 in “Research Square (Research Square)”

Certain nutraceuticals may enhance hair growth without affecting the cancer-fighting properties of tamoxifen.

research Nutraceuticals Known to Promote Hair Growth Do not Interfere with the Inhibitory Action of Tamoxifen in MCF7, T47D and BT483 Breast Cancer Cell Lines

December 2021 in “Research Square (Research Square)”

Hair growth-promoting nutraceuticals do not block the cancer-fighting effects of tamoxifen and may enhance its action.

research [Skin cells as steroid target; the steroid action in some skin diseases and wound healing].

1 citations , January 2005 in “PubMed”

Steroids affect skin health and healing, offering new treatment options.

research LB822 Nutraceuticals known to promote hair growth do not interfere with the inhibitory action of tamoxifen in breast cancer cells

August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair growth supplements do not reduce the effectiveness of the breast cancer treatment tamoxifen.

research Endocrine disruptors as risk factors for idiopathic premature thelarche in girls: A case-control study

1 citations , March 2025 in “Archivos Argentinos de Pediatria”

Exposure to certain chemicals in food and containers may increase the risk of early breast development in young girls.

research Sulfatase inhibitors: a patent review

47 citations , November 2012 in “Expert Opinion on Therapeutic Patents”

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

research Immuno-Endocrinology of COVID-19: The Key Role of Sex Hormones

16 citations , December 2021 in “Frontiers in Endocrinology”

Sex hormones may affect COVID-19 severity, with estrogen possibly reducing risk and testosterone potentially increasing it.

research Anogenital distance as a biomarker for incomplete masculinization : Molecular mechanisms in the perineum

January 2020 in “Research Portal Denmark”

A short male anogenital distance may indicate incomplete masculinization due to disrupted androgen action.

research Dermatologic Problems of Older Women

17 citations , April 2006 in “Dermatologic Clinics”

Older women face various skin issues like dryness and thinning, and treatments are available but can have side effects; proper skin care and legal health decisions are important.

research Palpable Purpura in an Elderly Man—Quiz Case

5 citations , October 2003 in “Archives of Dermatology”

The elderly woman experienced hair loss and scalp itching, especially at the front hairline, and lost her eyebrows.

research Androgen Action in the Ovary

62 citations , August 2018 in “Frontiers in Endocrinology”

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

research The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

130 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

research The Hair Follicle as an Estrogen Target and Source

159 citations , July 2006 in “Endocrine Reviews”

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

research Estrogens and aging skin

150 citations , April 2013 in “Dermato-endocrinology”

Estrogen therapy can reduce skin aging but has cancer risks.