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GlossaryEstrogenic Activity

ability of a substance to mimic or influence estrogen effects

Estrogenic activity refers to the ability of a substance to mimic or influence the effects of estrogen, a primary female sex hormone, in the body. This can impact various biological processes, including reproductive health, bone density, and hair growth. Substances with estrogenic activity can bind to estrogen receptors and trigger similar responses as natural estrogen, which is why they are significant in both medical treatments and environmental health studies.

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Hormonal Activity in Commonly Used Black Hair Care Products: Evaluating Hormone Disruption as a Plausible Contribution to Health Disparities

research Hormonal activity in commonly used Black hair care products: evaluating hormone disruption as a plausible contribution to health disparities

25 citations , May 2021 in “Journal of exposure science & environmental epidemiology/Journal of exposure science and environmental epidemiology”

Common Black hair care products may affect hormone levels and potentially impact health, especially in reproductive and metabolic areas.

research A Phytochemical and Pharmacological Review on Cynomorium songaricum as Functional and Medicinal Food

2 citations , April 2018 in “Natural Product Communications”

Cynomorium songaricum has many health benefits and could help with hair regrowth.

High Circulating Estrone and Low Testosterone Correlate with Adverse Clinical Outcomes in Men with Advanced Liver Disease

research High circulating oestrone and low testosterone correlate with adverse clinical outcomes in men with advanced liver disease

17 citations , March 2016 in “Liver international”

Men with advanced liver disease and high oestrone and low testosterone levels have worse health outcomes.

research Melatonin and the hair follicle

109 citations , October 2007 in “Journal of pineal research”

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Sex Hormone-Binding Globulin as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome

research Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome

58 citations , November 2020 in “International Journal of Molecular Sciences”

SHBG may be a useful early indicator and treatment target for PCOS.

research Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework

October 2025 in “Frontiers in Toxicology”

A new method effectively predicts estrogen-related health effects for early screening.

Complex Extract of Polygonatum Sibiricum and Nelumbinis Semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model

research Complex Extract of Polygonatum sibiricum and Nelumbinis semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model

May 2023 in “Nutrients”

A mix of Polygonatum sibiricum and Nelumbinis semen may ease menopause symptoms with fewer side effects.

research Contaminants of emerging concern in the fetal environment

November 2022

Fetal environments contain various chemicals that may disrupt hormones.

research Minoxidil May be a Partial Agonist of Estrogen Receptor Alpha

April 2026 in “microPublication”

Minoxidil might partially activate estrogen receptors, affecting hair growth.

research Red ginseng monograph

67 citations , May 2018 in “Journal of Ginseng Research”

Red ginseng may improve immunity, fatigue, memory, blood circulation, and menopausal symptoms, and is generally safe to consume.

Angelica Gigas Nakai (Korean Dang-Gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy: Active Phytochemicals and In Vivo Molecular Targets

research Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets

2 citations , January 2025 in “Pharmaceutical Research”

Angelica gigas Nakai root extracts may help with cancer, pain, memory loss, and metabolic issues.

research Women Also Use 5α-Reductase Inhibitors—Reply

November 2017 in “JAMA internal medicine”

Women also use 5α-reductase inhibitors, and their effects differ from men.

Dendrobium Officinale Polysaccharide Improves Hair Regrowth in Androgenetic Alopecia Mice and Is Associated with Coordinated Changes in Local Steroid Metabolism, ESR1 Activation, and Keratin-Related Follicular Responses

research Dendrobium officinale polysaccharide improves hair regrowth in androgenetic alopecia mice and is associated with coordinated changes in local steroid metabolism, ESR1 activation, and keratin-related follicular responses

May 2026 in “Frontiers in Pharmacology”

Dendrobium officinale polysaccharide helps hair regrowth in hair loss mice by affecting local steroid metabolism and hair follicle responses.

research Bioactivities of the Hydrous Ethanol Extract From Marine Green Alga Chlamydomonas Sp. W80

January 2019 in “International Journal of Plant Animal and Environmental Sciences”

The extract from marine green alga Chlamydomonas sp. W80 has antioxidant, anti-inflammatory, anti-aging, hair growth, immune-boosting, and skin lightening effects.

research Lansium domesticum—A Fruit with Multi-Benefits: Traditional Uses, Phytochemicals, Nutritional Value, and Bioactivities

36 citations , April 2022 in “Nutrients”

Langsat fruit has health benefits like fighting malaria, bacteria, and aging, but its peel is toxic.

research Women Also Use 5α-Reductase Inhibitors

November 2017 in “JAMA internal medicine”

Women also use 5α-reductase inhibitors for hair loss and hirsutism.

research Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An in Silico and in Vitro Study

29 citations , October 2020 in “Environmental health perspectives”

Five preservatives may disrupt hormone function and need more health and environmental risk assessment.

research Deciphering the Skin Anti-Aging and Hair Growth Promoting Mechanisms of Opophytum forskahlii Seed Oil via Network Pharmacology

December 2025 in “International Journal of Molecular Sciences”

Opophytum forskahlii seed oil may help with anti-aging and hair growth.

research Kelulut Honey Regulates Sex Steroid Receptors in a Polycystic Ovary Syndrome Rat Model

1 citations , November 2022 in “International Journal of Molecular Sciences”

Kelulut Honey can help regulate sex hormone receptors in rats with Polycystic Ovary Syndrome, similar to common medications.

research Expression Profiles of Reproduction- and Thyroid Hormone-Related Transcripts in the Brains of Chemically-Induced Intersex Frogs

24 citations , January 2011 in “Sexual Development”

Intersex frogs have different brain gene activity related to sex and thyroid hormones.

research A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer

431 citations , October 2008 in “Current Medicinal Chemistry”

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

research Androgens and Cardiovascular Disease

658 citations , June 2003 in “Endocrine reviews”

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

research New approaches to the treatment of osteoporosis

28 citations , August 2000 in “Current Opinion in Chemical Biology”

Future osteoporosis treatments should focus on increasing bone growth, with many promising options available.

research Wound Healing and the Use of Medicinal Plants

170 citations , September 2019 in “Evidence-based Complementary and Alternative Medicine”

Some medicinal plants can help heal wounds and may lead to new treatments.

Modeling Androgen Synthesis and Action During Human Sexual Differentiation

research Modelling androgen synthesis and action during human sexual differentiation

February 2010 in “ePrints Soton (University of Southampton)”

Male sexual differentiation is regulated independently, while female differentiation occurs in an androgenic environment, affecting conditions like congenital adrenal hyperplasia.

research Phenolsulphotransferase: localization in kidney during human embryonic and fetal development

18 citations , November 1994 in “Histochemical Journal”

The enzyme PST is found in developing human kidneys and helps with detoxification and development.

research Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

4 citations , June 2023 in “Frontiers in Aging”

Improving blood flow and oxygen levels in middle age may help prevent age-related diseases.