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DHT is needed for long-term depression, while E2 is needed for full long-term potentiation in male rat brains.

The availability of certain hormones and specific stimulation patterns affect long-term synaptic changes in the male rat brain.

Estrogen and androgen signals control synaptic changes in rat brains.

Neurosteroids like neuro-estrogen and neuro-androgen are crucial for brain function and can improve cognition and protect against aging-related decline.

Sex and stress steroids quickly change brain cell structures in the hippocampus.

Hormones during puberty increase certain receptors in the brain, and this change is influenced by estrogen levels.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

Finasteride use can cause lasting negative effects like sexual dysfunction, depression, anxiety, and cognitive issues.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Ovarian and stress hormones can change GABA A receptors through neurosteroids.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Neurosteroids show promise for treating epilepsy and more research is needed.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.

Male tissue has more cell death than female tissue after ischemia, and some neurosteroids only protect female cells.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Ketogenic diet, neurosteroids, and HMGB1-TLR4 signaling pathway are potential targets for new epilepsy treatments.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

In late pregnancy, allopregnanolone reduces stress responses in rats by affecting brain chemicals.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Stress and hormones like progesterone can affect absence seizures, but their effects change with different life stages.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride reduces inflammation and improves immune response after trauma by altering hormone levels.