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Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

research Defining stem cell dynamics and migration during wound healing in mouse skin epidermis

363 citations , March 2017 in “Nature Communications”

Stem cells help heal wounds by rapidly dividing and migrating to the wound edge.

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

research Identification of the cell lineage at the origin of basal cell carcinoma

351 citations , February 2010 in “Nature Cell Biology”

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

IL-17-Producing Gamma Delta T Cells Enhance Bone Regeneration

research IL-17-producing γδ T cells enhance bone regeneration

343 citations , March 2016 in “Nature Communications”

IL-17-producing γδ T cells help improve bone healing.

research Bioactivities, isolation and purification methods of polysaccharides from natural products: A review

305 citations , July 2016 in “International Journal of Biological Macromolecules”

Polysaccharides have many health benefits and are used in drugs, but isolating and purifying them is complex and requires careful methods.

Deletion of DNA Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

research Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

277 citations , July 2002 in “Molecular Endocrinology”

Removing part of the vitamin D receptor stops vitamin D from working properly.

research Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

271 citations , September 2008 in “Nutrition reviews”

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

research Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo

264 citations , January 2008 in “Journal of biomedical optics”

Zinc oxide nanoparticles in sunscreen do not penetrate deep into the skin.

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