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GlossaryEx Vivo Culture

growing cells or tissues outside their original biological context

Ex Vivo Culture refers to the process of growing or maintaining cells, tissues, or organs outside of their original biological context, typically in a controlled laboratory environment. This technique allows researchers to study biological processes in a more natural state than in vitro (in a petri dish) while still being able to manipulate and observe the sample closely. For example, hair follicles can be cultured ex vivo to study hair growth and alopecia treatments.

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research A simple method using ex vivo culture of hair follicle tissue to investigate intrinsic circadian characteristics in humans

12 citations , July 2017 in “Scientific reports”

Researchers developed a way to study human body clocks using hair tissue, which works similarly in both healthy and dementia patients.

research Ex Vivo Organ Culture of Human Hair Follicles: A Model Epithelial–Neuroectodermal–Mesenchymal Interaction System

13 citations , October 2010 in “Methods in molecular biology”

Hair follicle culture helps study cell interactions and effects of substances on tissue growth.

Human Hair Growth Ex Vivo Is Correlated With In Vivo Hair Growth: Selective Categorization of Hair Follicles for More Reliable Hair Follicle Organ Culture

research Human hair growth ex vivo is correlated with in vivo hair growth: selective categorization of hair follicles for more reliable hair follicle organ culture

27 citations , November 2005 in “Archives of Dermatological Research”

Choosing hair follicles at the same growth stage leads to more consistent hair growth experiments.

Prostaglandin F2α Stimulates Growth of Human Intermediate Hair Follicles in Ex Vivo Organ Culture with Potential Clinical Relevance

research Prostaglandin F2α stimulates the growth of human intermediate hair follicles in ex vivo organ culture with potential clinical relevance

June 2025 in “Frontiers in Physiology”

Prostaglandin F2α may help treat hair loss by promoting hair growth.

research Identification of human hair follicle antigens targeted in the presumptive autoimmune hair follicle disorder alopecia areata and their potential functional relevance in vitro : methods development for isolation and identification of alopecia areata-relevant human hair follicle antigens using a proteomics approach and their functional assessment using an ex vivo hair follicle organ culture model

January 2008 in “Bradford Scholars (University of Bradford)”

Alopecia areata may be caused by antibodies targeting specific hair follicle proteins, hindering hair growth.

research Ex-vivo Hair Growth Promotion Efficacy of Biofield Energy Treated Williams Medium E using Vibrissae Hair Follicle Organ Culture

December 2018 in “Zenodo (CERN European Organization for Nuclear Research)”

Biofield Energy Treatment may promote hair growth and help treat certain skin conditions.

Intrinsic Activation of Cell Growth and Differentiation in Ex Vivo Cultured Human Hair Follicles by a Transient Endogenous Production of ROS

research Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS

9 citations , March 2019 in “Scientific reports”

Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.

Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives

research 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives

November 2022 in “Journal of Investigative Dermatology”

The document concludes that a new method has been developed to test anti-aging substances on human skin, showing that these substances can reduce skin aging signs.

Generation of Human Hair Follicle Organoids In Vitro and Ex Vivo by Co-Culture of Primary Human Hair Matrix Keratinocytes and Dermal Papilla Fibroblasts

research 773 Generation of human hair follicle organoids in vitro and ex vivo by co-culture of primary human hair matrix keratinocytes and dermal papilla fibroblasts

June 2020 in “Journal of Investigative Dermatology”

Scientists successfully grew mini hair follicles using human skin cells, which could help treat baldness.

research 613 Assessment of the induction and morphogenic potential of human hair matrix cells and dermal papilla fibroblasts ex vivo

1 citations , September 2019 in “Journal of Investigative Dermatology”

Human hair matrix cells and dermal papilla fibroblasts can form early hair follicle structures but don't produce hair shafts yet.

research Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

208 citations , January 2013 in “Lab on a Chip”

The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.

research Effect of Orthosiphon stamineus plant extract on in vitro dermal papilla cell proliferation and ex vivo hair growth

1 citations , January 2017 in “Deleted Journal”

Orthosiphon stamineus extract can significantly boost hair growth and cell proliferation in hair loss patients.

An Umbilical Cord Blood-Derived Exosome Product Stimulates Hair Growth Through Laminin V and Collagen XVII: An Ex Vivo Study

research A umbilical cord blood-derived exosome product simulates hair growth through laminin V and collagen XVII: an ex vivo study

November 2025 in “Archives of Dermatological Research”

Limelight (CB-EVs) safely promotes hair growth.

research Dedifferentiation of committed epithelial cells into stem cells in vivo

551 citations , November 2013 in “Nature”

Certain mature cells in mouse lungs can turn back into stem cells to aid in tissue repair.

research Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging

March 2026 in “Ageing Research Reviews”

Advanced lab models are needed to better study human skin aging and develop treatments.

research In vitro models to study hair follicle generation

5 citations , November 2017 in “Elsevier eBooks”

Scientists can now grow hair-like structures in a lab using special 3D culture systems, which could potentially help people with hair loss or severe burns.

Glycogen Phosphorylase Inhibitor Promotes Hair Growth via Protecting from Oxidative Stress and Regulating Glycogen Breakdown in Human Hair Follicles

research Glycogen Phosphorylase Inhibitor Promotes Hair Growth via Protecting from Oxidative-Stress and Regulating Glycogen Breakdown in Human Hair follicles

August 2024 in “Biomolecules & Therapeutics”

A new compound, HTPI, promotes hair growth by protecting cells from damage and regulating energy use.

research Non-thermal atmospheric pressure plasma activates Wnt/β-catenin signaling in dermal papilla cells

24 citations , August 2021 in “Scientific Reports”

Non-thermal plasma could help hair growth by activating key cell signals.

research Hair Growth Promoting Effect of Urticadioica L

September 2018 in “Central Asian journal of medical sciences (Print)”

Urticadioica L extract may enhance human hair growth.

Panax Ginseng Extract Antagonizes the Effect of DKK-1-Induced Catagen-Like Changes of Hair Follicles

research Panax ginseng extract antagonizes the effect of DKK-1-induced catagen-ike changes of hair follicles

15 citations , August 2017 in “International Journal of Molecular Medicine”

Panax ginseng extract may help prevent hair loss caused by DKK-1.

research The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target

December 2023 in “Communications biology”

Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.

research Experimental assessment of regenerative properties of platelet rich plasma on the human skin - a review

January 2022 in “Pastic and aesthetic research”

PRP helps skin regeneration but needs standardized testing for consistent results.

research Tissue engineering of human hair follicles using a biomimetic developmental approach

184 citations , December 2018 in “Nature Communications”

Researchers created human hair follicles using a new method that could help treat hair loss.

Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata

research Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells of a Healthy Donor on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata: Targeting Dysregulated T Cells and the Acquisition of Immunotolerance

1 citations , October 2022 in “International Journal of Molecular Sciences”

Using healthy donor stem cells can potentially calm overactive immune cells and reduce inflammation in severe hair loss patients, offering a possible treatment method.

research Evaluation of the activity of laser light doses compared to an inactive control dose on ex vivo hair growth

February 2010 in “Journal of The American Academy of Dermatology”

Low-level laser therapy increased hair growth compared to no treatment.

research Macrophage-Stimulating Protein Promotes Hair Growth Ex Vivo and Induces Anagen from Telogen Stage Hair Follicles In Vivo

25 citations , June 2004 in “Journal of Investigative Dermatology”

Macrophage-stimulating protein helps hair grow and can start hair growth phase in mice and human hair samples.

Vitamins and Their Derivatives Synergistically Promote Hair Shaft Elongation via PlGF/VEGFR-1 Signalling Activation

research Vitamins and their derivatives synergistically promote hair shaft elongation ex vivo via PlGF/VEGFR-1 signalling activation

1 citations , September 2022 in “Journal of dermatological science”

Certain vitamins and their derivatives can help hair grow longer by activating specific growth signals.

research 509 Using the human iPSCs-derived sensory neurons re-innervated skin ex vivo model to investigate mast cell-nerve fiber cross-talk in solar elastosis

November 2024 in “Journal of Investigative Dermatology”

Nerve fibers may worsen mast cell activity, leading to abnormal elastic fiber buildup from sun exposure.

research 1372 Biological effects of electrical epilation on human hair follicles and perifollicular skin ex vivo

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Electrical epilation damages hair follicles and surrounding skin, likely preventing hair regrowth.

research Analysis of Dermal Papilla Cell Interactome Using STRING Database to Profile the ex Vivo Hair Growth Inhibition Effect of a Vinca Alkaloid Drug, Colchicine

23 citations , February 2015 in “International Journal of Molecular Sciences”

Colchicine can inhibit hair growth by affecting cell activity and protein expression in hair follicles.