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High-dose glucocorticoid therapy clears skin lesions in pemphigus vulgaris but causes side effects like weight gain and muscle weakness.

Male C57BL/6 mice show age-related fluctuations in certain hormones and their ratios in both blood and hair.

Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

A dog developed skin issues from too many steroids, but reducing steroids and using a specific treatment fixed the problems.

Adrenal tumors should be considered in Addison's disease if unusual results appear, with surgery as a solution.

Glucocorticoids affect dogs' skin reactions to histamine, which vary by time of day.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

The method can measure multiple steroids in human hair to study long-term steroid metabolism, especially in newborns and children.

Polycystic Ovary Syndrome (PCOS) often leads to severe acne, and lifestyle changes and hormonal treatments can help manage it.

Women with PCOS have higher 5alpha-reductase activity, affecting steroid levels.

High glucocorticoids cause pancreatic malfunction and malabsorption, reversible with enzyme supplements.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

Testosterone therapy increases bone density in older men with low testosterone levels.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Screen young women with menstrual issues, acne, or excess hair for high cortisol to avoid misdiagnosis.

Generalized glucocorticoid resistance causes hormone imbalances and varied symptoms due to gene mutations.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

A new gene variant causes glucocorticoid resistance in a mother and son.

Blocking 11β-HSD1 can lessen the harmful effects of glucocorticoids on hair growth cells.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

Cedrol may help reduce liver fat and fat cell growth caused by corticosteroids.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

The N363S gene variant does not cause higher adrenal androgen levels in women with polycystic ovary syndrome.

Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.