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GlossaryExtracellular Matrix Proteins

provide structural and biochemical support to surrounding cells

Extracellular Matrix Proteins (ECM Proteins) are a group of molecules secreted by cells that provide structural and biochemical support to the surrounding cells. These proteins, such as collagen, elastin, and fibronectin, form a complex network that helps maintain tissue integrity, facilitates cell communication, and plays a crucial role in wound healing and tissue regeneration.

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The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility

research The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility

44 citations , June 2009 in “Biomaterials”

Skin cell clumping for hair growth is improved by a protein called fibronectin, which helps cells stick and move better.

research Development of Hair Follicle Dermal Papilla Spheroids Encapsulated in Alginate Hydrogel with Extracellular Matrix Protein

November 2024

Encapsulating hair follicle cells in a special gel boosts their activity.

research Endothelin-1 combined with extracellular matrix proteins promotes the adhesion and chemotaxis of amelanotic melanocytes from human hair follicles in vitro

11 citations , August 2006 in “Cell Biology International”

Endothelin-1 helps amelanotic melanocytes stick and move better on certain proteins.

Combination of Media, Biomaterials, and Extracellular Matrix Proteins to Enhance the Differentiation of Neural Stem/Precursor Cells into Neurons

research Combination of media, biomaterials and extracellular matrix proteins to enhance the differentiation of neural stem/precursor cells into neurons

25 citations , April 2012 in “Acta Biomaterialia”

Using certain small proteins with a growth factor and specific materials can increase the creation of neurons from stem cells.

research Latent transforming growth factor beta-binding protein 1 (LTBP1): roles as a multifunctional extracellular matrix regulator in human disease. From molecular mechanisms to clinical translation prospects

March 2026 in “Folia Histochemica et Cytobiologica”

LTBP1 is a key regulator in diseases and a potential target for new treatments.

Dipeptidyl-Peptidase 4 (DPP4)-Positive Fibroblasts Are Responsible for Secretion of Pro-Fibrotic Matrix Proteins in Human Skin

research 973 Dipeptidyl-peptidase 4 (DPP4)-positive fibroblasts are responsible for secretion of pro-fibrotic matrix proteins in the human skin

April 2019 in “Journal of Investigative Dermatology”

DPP4-positive fibroblasts play a major role in producing proteins that lead to skin fibrosis.

research Expression of extracellular matrix in hair follicle mesenchyme in alopecia areata

11 citations , December 1990 in “British Journal of Dermatology”

Alopecia areata may involve disrupted mesenchymal function in hair follicles.

research Cartilage oligomeric matrix protein (COMP) forms part of the connective tissue of normal human hair follicles

14 citations , February 2011 in “Experimental dermatology”

A protein called COMP is part of the connective tissue in normal human hair follicles and may be important for hair health.

research Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin

2 citations , September 2023 in “International journal of molecular sciences”

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

research Extracellular matrix sensing by FERONIA and Leucine‐Rich Repeat Extensins controls vacuolar expansion during cellular elongation in Arabidopsis thaliana

172 citations , March 2019 in “The EMBO Journal”

FERONIA and LRX proteins help control cell growth in plants by regulating vacuole expansion.

research Electrospinning based biomaterials for biomimetic fabrication, bioactive protein delivery and wound regenerative repair

December 2024 in “Regenerative Biomaterials”

Electrospinning creates materials that help heal wounds by mimicking natural tissue and delivering proteins.

research Antibacterial and wound healing stimulant nanofibrous dressing consisting of soluplus and soy protein isolate loaded with mupirocin

38 citations , November 2024 in “Scientific Reports”

The new wound dressing speeds up healing and kills bacteria effectively.

research From Design to Production: Applications of Polymer and Protein Nanofibers for Regenerating Tissue

September 2018 in “Digital Access to Scholarship at Harvard (DASH) (Harvard University)”

FN nanofiber dressings improve wound healing and restore natural skin structure.

Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

research Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering

74 citations , January 2013 in “Expert Opinion on Biological Therapy”

The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.

research Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis

59 citations , November 2011 in “Development”

Trps1 is essential for proper hair follicle development.

research Gene Expression in Rat Dermal Papilla Cells: Analysis of 2529 ESTs

14 citations , October 2000 in “Genomics”

Rat dermal papilla cells have unique genes crucial for hair growth.

research In vitro and ex vivo examination of topical Pomiferin treatments

10 citations , February 2014 in “Fitoterapia”

Pomiferin may improve skin and hair by increasing important protein production.

research Expression of an Olfactomedin-Related Gene in Rat Hair Follicular Papilla Cells

10 citations , June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

FP-1 is a key protein in rat hair growth, active only during the growth phase.

research Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome

9 citations , September 2022 in “Journal of Clinical Investigation”

Replacing defective mesenchymal cells with normal ones fixes thymic growth issues in 22q11.2DS mouse models.

research Gellan gum-based hydrogels support the recreation of the dermal papilla microenvironment

1 citations , April 2023 in “Biomaterials advances”

Gellan gum hydrogels help recreate the environment needed for hair growth cell function.

research Co-opting Developmental Signaling Pathways to Promote Wound Healing

1 citations , January 2018 in “Recent clinical techniques, results, and research in wounds”

Using developmental signaling pathways could improve adult wound healing by mimicking scarless embryonic healing.

research A novel cell-free regenerative therapy for hair loss: human fetal cartilage progenitor cell secretome

August 2025 in “Biomaterials”

A new therapy using secretions from fetal cartilage cells shows promise for safe and effective hair regrowth.

research Human hair keratin gradient metallogel and their applications for wound healing

January 2024

The research developed a human hair keratin and silver ion hydrogel that could help heal wounds.

Pomiferin: A Potent Stimulant of Extracellular Matrix Proteins

research Cover stories: 10 start-ups to watch: Liquid Light

December 2015 in “Focus on catalysts”

Pomiferin may improve skin and scalp health by boosting important protein expression.

research Hair Restoration: Looking Beyond Minoxidil, Finasteride and Hair TransplantationSonthalia*

January 2015

The document concludes that current hair loss treatments have limitations and suggests researching new treatments targeting different factors of hair loss.