18 citations
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December 2010 in “The Journal of Steroid Biochemistry and Molecular Biology” Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.
April 2021 in “Journal of Investigative Dermatology” Bacteria can help skin regenerate through a process called IL-1β signaling.
February 2024 in “Clinical and Experimental Obstetrics & Gynecology” PCOS women have more arm fat and higher insulin resistance and glucose levels than non-PCOS women.
53 citations
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August 2019 in “American journal of human genetics” FOXN1 gene variants cause low T cells and immune issues from birth.
28 citations
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May 2012 in “Veterinary Dermatology” Different types of dog hair loss are linked to problems starting the hair growth phase and early hair cycle ending.
15 citations
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January 2002 in “Gynecological endocrinology” Hormones affect skin aging and fat distribution, and treatments can help, but only minoxidil is proven for female hair loss.
7 citations
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October 2024 in “AAPS PharmSciTech” CA-SLN-Ngel significantly reduces cellulite more effectively than regular caffeine gel.
128 citations
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December 2006 in “Journal of Biological Chemistry” Altering SSAT affects fat metabolism and body fat in mice.
31 citations
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May 2017 in “JAAD Case Reports” ATX-101 injections can cause hair loss.
45 citations
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August 2018 in “Stem Cells International” Stem cells, especially from fat tissue and Wharton's jelly, can potentially regenerate hair follicles and treat hair loss, but more research is needed to perfect the treatment.
14 citations
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May 2019 in “Experimental Dermatology” Fat tissue extract may help treat vitiligo by reducing cell stress and promoting skin repair.
5 citations
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February 2025 in “Cell Reports” Skin acetyl-CoA synthesis is crucial for overall lipid balance.
18 citations
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August 2017 in “PLOS ONE” Skin and its underlying fat layer act together to resist mechanical stress, and reinforcing this composite structure may help more with anti-aging than just strengthening the skin alone.
131 citations
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September 2017 in “Molecular and Cellular Endocrinology” The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
128 citations
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October 2011 in “Development” Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.
29 citations
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January 2021 in “Journal of Investigative Dermatology” Fat under the skin releases HGF which helps hair grow and gain color.
18 citations
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October 2021 in “Frontiers in Physiology” Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.
8 citations
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June 2023 in “Journal of clinical medicine” Nanofat shows promise for facial rejuvenation and treating skin issues but needs more research for long-term safety.
5 citations
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July 2024 in “Aesthetic Surgery Journal” Fat grafting is more effective and safer for correcting jowls than ligament release.
3 citations
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March 2023 in “Life” Obesity can worsen wound healing by negatively affecting the function of stem cells in fat tissue.
2 citations
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January 2017 in “AIMS cell and tissue engineering” Mesenchymal stem cells show promise for treating various skin conditions and may help regenerate hair.
March 2026 in “Preprints.org” The MIRA technique improves cellulite treatment results and patient satisfaction.
December 2024 in “Frontiers in Neurology” Testosterone with finasteride improved muscle and bone health in men with spinal cord injury.
February 2022 in “Journal of Investigative Dermatology” Newborn skin cells can change into wound-healing cells more easily than adult ones, which might explain why baby skin heals without scars. Understanding this could help treat chronic wounds and prevent scarring.
136 citations
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September 2019 in “Journal of Clinical Investigation” Dermal adipose tissue in mice can change and revert to help with skin health.
115 citations
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December 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology” Skin cells called dermal fibroblasts are important for skin growth, hair growth, and wound healing.
44 citations
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June 2023 in “Cell Reports” IL-1 promotes fat cell growth in skin, while WNT inhibits it and encourages scar formation.
5 citations
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October 2021 in “Frontiers in Cell and Developmental Biology” Fat tissue under the skin affects hair growth and aging; reducing its inflammation may help treat hair loss.
2 citations
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November 2022 in “Journal of Biochemistry and Molecular Biology” Aging changes hair stem cells and their environment, leading to gray hair and hair thinning, but understanding these changes could help develop treatments for hair regeneration.
October 2025 in “Preprints.org” Adipose mesenchymal stem cells are best for skincare because they reduce inflammation and are safe and effective.