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ELife Assessment: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

research eLife assessment: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

February 2024

Meis2 is essential for touch sensation and proper nerve connection to touch receptors in certain skin areas of mice.

research The Combination of Natural Compounds Escin–Bromelain–Ginkgo Biloba–Sage Miltiorrhiza (EBGS) Reduces Platelet Adhesion to TNFα-Activated Vascular Endothelium through FAK Signaling

4 citations , August 2024 in “International Journal of Molecular Sciences”

EBGS reduces platelet adhesion, potentially helping prevent blood clots.

Probing Androgen Receptor Co-Factor Selectivity Profiles: A Chemical Tool to Determine Cross-Talk Between Androgen Receptor and Beta-Catenin In Vivo

research Probing androgen receptor co-factor selectivity profiles: a chemical tool to determine cross-talk between androgen receptor and β-catenin in vivo

1 citations , January 2013 in “MedChemComm”

PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

research 879 Molecular network of Smads and Id2 genes in hair follicle stem cells regulation

April 2017 in “Journal of Investigative Dermatology”

The BMP/Smads pathway and Id2 gene control hair follicle stem cells, affecting their rest and growth phases.

research Role of Vitamin D receptor in adult hair follicle cycling

March 2006 in “The FASEB Journal”

Vitamin D receptor is essential for adult hair growth.

research GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing

19 citations , January 2015 in “Scientific Reports”

GPR39 is linked to certain cells in the sebaceous gland and helps with skin healing.

research The T-cell antigen receptor: paradigm recalled

October 1984 in “Immunology Today”

research Identification of functional circRNAs regulating ovarian follicle development in goats

8 citations , September 2024 in “BMC Genomics”

circCFAP20DC helps goat ovarian cells grow, aiding follicle development.

research Nerve growth factor regulates the proliferation of cashmere goat outer root sheath cells through the activation of cAMP-binding protein

1 citations , July 2019 in “Small ruminant research”

Nerve growth factor helps cashmere goat hair cells grow by activating a specific protein.

Molecular Profiling of Frontal Fibrosing Alopecia Reveals TH1 and JAK-STAT Up-Regulation with No Suppression of Hair Keratins

research 1322 Molecular profiling of frontal fibrosing alopecia (FFA) reveals TH1 and JAK-STAT up-regulation with no suppression of hair keratins

2 citations , April 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

research In vivo effects of epidermal growth factor on epidermal pattern formation and hair follicle initiation in the marsupial bandicoot Isoodon macrourus

7 citations , November 1997 in “Reproduction Fertility and Development”

Epidermal growth factor disrupts hair and gland formation in bandicoots.

research Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles.

35 citations , April 1998 in “PubMed”

Activated erbB-2 in mice skin causes severe skin and hair abnormalities.

research Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers

3 citations , January 2011 in “Annals of Dermatology”

Blocking EGFR in skin cells doesn't majorly increase inflammation markers.

17β-Estradiol May Control Human Hair Follicle Growth Also via Up-Regulating the Expression of Cannabinoid Receptor Type 1

research 1370 17β-estradiol may control human HF growth also via up-regulating the expression of cannabinoid receptor type1 expression

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.

research The Insulin-like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia

128 citations , March 1996 in “Journal of Investigative Dermatology”

research Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration

October 2025 in “Cell Reports”

Regulatory T cells help hair growth by using the Cxcr4-Cxcl12 pathway.

research A smart deoxyribozyme-based fluorescent sensor for in vitro detection of androgen receptor mRNA

1 citations , May 2020 in “Beilstein Journal of Organic Chemistry”

Scientists made a sensor that can detect a specific type of RNA related to androgen receptors quickly and accurately.

research The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

344 citations , May 2018 in “EMBO journal”

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

research CD98hc (SLC3A2) regulation of skin homeostasis wanes with age

35 citations , January 2013 in “The Journal of experimental medicine/The journal of experimental medicine”

CD98hc's role in skin health decreases with age.

Recent Progress in Prostaglandin F2α Ethanolamide (Prostamide F2α) Research and Therapeutics

research Recent Progress in Prostaglandin F₂_αEthanolamide (Prostamide F₂_α) Research and Therapeutics

43 citations , July 2013 in “Pharmacological reviews”

New research on prostamide F2α has led to treatments for glaucoma and eyelash growth and may have more medical uses.

research Synthesis of nerve growth factor mRNA in cultures of developing mouse whisker pad, a peripheral target tissue of sensory trigeminal neurons.

5 citations , March 1993 in “The Journal of Cell Biology”

A soluble factor in developing mouse whisker pads boosts nerve growth factor mRNA production.

research The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity

55 citations , November 2010 in “Journal of Allergy and Clinical Immunology”

The L412F variant of TLR3 is linked to skin infections, more viral infections, and autoimmune issues.

research Mutations in the vitamin D receptor and hereditary vitamin D-resistant rickets

107 citations , March 2014 in “BoneKEy Reports”

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

research Keratinocyte Growth Factor Modified Messenger RNA Accelerating Cell Proliferation and Migration of Keratinocytes

11 citations , October 2018 in “Nucleic Acid Therapeutics”

Modified KGF mRNA helps skin cells grow and move faster, which may improve wound healing.

research Aberrant expression of epidermal growth factor receptor in aural cholesteatoma

48 citations , March 1993 in “The Laryngoscope”

Cholesteatoma shows abnormal and increased EGF receptor expression, indicating its rapid growth.

research miR-140-y targets TCF4 to regulate the Wnt signaling pathway and promote embryonic feather follicle development in Hungarian white goose

4 citations , February 2024 in “Poultry Science”

miR-140-y helps control feather growth in geese by affecting the Wnt signaling pathway.

research Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1

37 citations , June 1996 in “Journal of cellular physiology”

Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.

research Extracellular matrix sensing by FERONIA and Leucine‐Rich Repeat Extensins controls vacuolar expansion during cellular elongation in Arabidopsis thaliana

172 citations , March 2019 in “The EMBO Journal”

FERONIA and LRX proteins help control cell growth in plants by regulating vacuole expansion.

research Deletion of an enhancer in FGF5 is associated with ectopic expression in goat hair follicles and the cashmere growth phenotype

December 2020 in “Research Square (Research Square)”

A genetic change in the FGF5 gene affects hair growth in cashmere goats.

research Two siblings with a novel nonsense mutation, p.R50X, in the vitamin D receptor gene

8 citations , March 2011 in “Endocrine”

A new gene mutation causes vitamin D-resistant rickets and hair loss in two siblings.

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