research Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases
Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.
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research Developing human fetal skin demonstrates a unique lymphocyte signature
Fetal skin has unique immune cells different from adult skin.
research 3D spheroid culture synchronizes heterogeneous MSCs into an immunomodulatory phenotype with enhanced anti-inflammatory effects
3D spheroid culture makes stem cells better at reducing inflammation.
research Serum Level of Macrophage Migration Inhibitory Factor (MIF) in Egyptians With Alopecia Areata and Its Relation to the Clinical Severity of the Disease
Higher MIF levels in alopecia areata patients suggest it could be a treatment target and disease predictor.
research Frontal Fibrosing Alopecia Involving the Limbs Shows Inflammatory Pattern on Histology: A Review of 13 Cases
Frontal fibrosing alopecia on limbs shows permanent inflammatory hair loss, not typical scarring.
research Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis
Reprogramming macrophages to resolve inflammation can help reduce severe COVID-19 complications.
research Targeted Inactivation of Gh/Tissue Transglutaminase II
Tgm2 helps stabilize dying cells and aids fibroblast attachment to the extracellular matrix.
research Major Differences in Expression of Inflammatory Pathways in Skin from Different Body Sites of Healthy Individuals
Different parts of the body have unique immune characteristics in their skin.
research Fibroblasts and wound healing: an update
Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.
research Commensal microbe regulation of skin cells in disease
research Skin-associated adipocytes in skin barrier immunity: A mini-review
Skin-associated adipocytes help protect the skin from infections by supporting its immune barrier.
research Local heroes or villains: tissue-resident memory T cells in human health and disease
Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.
research 1347 Updated skin transcriptomic atlas depicted by reciprocal contribution of single-nucleus RNA sequencing and single-cell RNA sequencing
The research updated the skin cell profile, finding new skin cell markers and showing fibroblasts' key role in skin health.
research Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment
The document concluded that more research is needed to find the best treatment for Frontal fibrosing alopecia.
research Refractory dermatomyositis–systemic lupus erythematosus overlap syndrome and response to tofacitinib
Tofacitinib successfully treated a woman's severe symptoms from a rare autoimmune condition.
research Integrated multiple machine learning and Mendelian randomization reveal LTF gene as a prognostic biomarker for nonspecific orbital inflammation
The LTF gene may help predict and manage nonspecific orbital inflammation.
research Frontal fibrosing alopecia in association with Sjögren's syndrome: more than a simple coincidence
Frontal Fibrosing Alopecia may be linked to autoimmune diseases like Sjögren's syndrome.
research Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction
Advances in mechanobiology and immunology could lead to scarless wound healing.
research Multifunctional and immunoregulatory microenvironment-responsive hydrogel for whole course management of infected diabetic wounds
The ATAN-Met hydrogel helps heal infected diabetic wounds by promoting tissue regeneration and fighting bacteria.
research Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice
TNFα and interleukin-1 blockers reduce skin inflammation from EGFR antibody therapy.
research Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice
TNFα and interleukin-1 blockers reduce skin inflammation from EGFR antibody therapy.
research Aberrant B cell and cytotoxic T cell activation in female pattern hair loss: a pilot comparative clinico-transcriptomic study
Immune system issues may contribute to female pattern hair loss.
research Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration
Helminth protein helps wounds heal better by reducing scarring and promoting tissue growth.
research Frontal fibrosing alopecia: reflections and hypotheses on aetiology and pathogenesis
FFA's causes may include environmental triggers and genetic factors.
research 730 M2 macrophages promote wound induced hair neogenesis through the production of growth factors
M2 macrophages help hair regrowth in wounds by making growth factors.
research Wounds and the Microbiota: The Healing Interplay Between Host and Microbial Communities
Balancing good and harmful microbes is key to healing chronic wounds.
research 068 Pathogenic Th17 cells, CD8+CD69+CD49a- tissue-resident memory T cells and common γ chain receptor + natural killer cells express more IL-17, compared to IFN-γ, under the foxp3+ memory regulatory T cells-depleted microenvironment in patients with chronic alopecia areata
IL-17 plays a key role in severe hair loss in chronic alopecia areata.
research 364 Mechanical forces of human dermal fibroblasts significantly decrease with age
Skin cell strength decreases significantly as we age.
research Inflammatory Phenomena and Fibrosis in Androgenetic Alopecia
Hair loss in androgenetic alopecia may be due to ongoing tiny inflammation and tissue changes around hair follicles.
research Senescence-induced reparative fibroblasts enable scarless wound healing in aged murine skin.
Older mice heal wounds without scars due to special fibroblasts.