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research Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

252 citations , November 1995 in “The EMBO Journal”

Blocking EGFR in mice causes hair loss and skin changes.

research A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease

67 citations , November 2019 in “Nature Communications”

Oncogenic melanocyte stem cells can develop into melanoma similar to human cases.

research Prenatal transplantation of epidermal neural crest stem cells in malformation of cortical development mouse model

5 citations , December 2016 in “Microscopy Research and Technique”

EPI-NCSCs from hair follicles may help treat brain development issues in mice.

research Development of Woolly Hair and Hairlessness in a CRISPR−Engineered Mutant Mouse Model with KRT71 Mutations

July 2023 in “Cells”

Researchers made a mouse model with curly hair and hair loss by editing a gene.

research CD8-positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Mice

7 citations , February 2015 in “Journal of comparative pathology”

CD8+ T cells play a key role in graft-versus-host disease in certain mice models.

research HtrA1L364P leads to cognitive dysfunction and vascular destruction through TGF‐β/Smad signaling pathway in CARASIL model mice

3 citations , July 2022 in “Brain and Behavior”

The HtrA1L364P mutation causes brain dysfunction and blood vessel damage.

research Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1

75 citations , February 2017 in “Aging”

SkQ1 antioxidant improved health and lifespan in mice.

research Targeted Knockout of β-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects

3 citations , October 2020 in “Journal of Investigative Dermatology”

Removing β-catenin in certain stem cells causes hair whitening and pigmentation issues.

research Regeneration of Mouse Skin Melanocyte Stem Cells In Vivo and In Vitro

1 citations , January 2018 in “Methods in molecular biology”

The research found ways to activate melanocyte stem cells for potential treatment of skin depigmentation conditions.

research Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice

April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Removing Sprouty genes in mice causes various hormone-related issues but does not increase cancer risk by one year of age.

research Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells

31 citations , February 2007 in “Molecular Carcinogenesis”

Overexpressing ATF3 in mice's epithelial cells may lead to oral cancer.

Recombinant Goat VEGF164 Increases Hair Growth by Painting Process on the Skin of Shaved Mice

research Recombinant Goat VEGF164 Increases Hair Growth by Painting Process on the Skin of Shaved Mouse

1 citations , August 2014 in “Asian-Australasian Journal of Animal Sciences”

Recombinant goat VEGF164 speeds up hair growth in mice.

research MOUSE MODELS FOR THE STUDY OF HUMAN HAIR LOSS

36 citations , October 1996 in “Dermatologic Clinics”

Mice are useful for researching human hair loss and testing treatments, despite some differences between species.

research The mouse frizzy (fr) and rat ‘hairless’ (fr^CR) mutations are natural variants of protease serine S1 family member 8 (Prss8)

28 citations , February 2010 in “Experimental Dermatology”

The frizzy mouse and hairless rat mutations are due to changes in the Prss8 gene.

research “Dark Cells” in Normal, Hyperplastic, and Promoter-Treated Mouse Epidermis Studied by Conventional and High-Voltage Electron Microscopy

27 citations , July 1983 in “Journal of Investigative Dermatology”

research Defining a Region of the Human Keratin 6a Gene That Confers Inducible Expression in Stratified Epithelia of Transgenic Mice

44 citations , May 1997 in “Journal of Biological Chemistry”

The human keratin 6a gene's specific sequences trigger expression in skin layers after injury.

research Over-, ectopic-expression of FoxN1 at early life adversely influences lymphopoiesis (HEM3P.280)

May 2014 in “The journal of immunology/The Journal of immunology”

Early over-expression of FoxN1 harms immune and skin development.

research Balding: A New Mutation on Mouse Chromosome 18 Causing Hair Loss and Immunological Defects

22 citations , March 1994 in “Journal of Heredity”

A mutation in mice causes hair loss and immune problems.

research The promoter of an androgen dependent gene in the hamster flank organ

6 citations , May 1997 in “Journal of Dermatological Science”

Researchers found a gene in hamsters that responds to male hormones and may be indirectly controlled by them.

research Hair Follicle Development and Hair Growth from Defined Cell Populations Grafted onto Nude Mice

11 citations , May 1995 in “The journal of investigative dermatology/Journal of investigative dermatology”

research A transgenic mouse model to study the role of epidermal growth factor (EGF) in hair and skin development

January 2002

EGF affects hair and skin development.

research The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region

2 citations , July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Proteolytic enzymes damaged hair follicle stem cells in transgenic mice.

research Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity

372 citations , December 2004 in “Nature Genetics”

The Accelerated Aging Skin in Rhino-Like SHJHhr Mice

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