May 2026 in “The EMBO Journal” The study investigates the formation of feather follicles in avian skin using chicken and transgenic quail skin models. It reveals that novel cellular flows initiate chemo-mechanical circuits that guide the morphological transitions necessary for feather bud formation. Initially, stiff dermal condensates protrude from a softened epithelial sheet, activating YAP and causing the epithelial sheet to fold and form a cylindrical wall that invaginates into the skin. This process is crucial for forming tightly packed dermal papillae. The study contrasts this with scale development, where a rigid epithelial sheet restricts dermal cell flows, preventing further transformation. A topological transformation model was developed to describe how feather follicles evolved from scales.
April 2007 in “Linchuang pifuke zazhi” TGF-β1 and 2 may play a role in hair loss in AGA.
Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.
66 citations
,
July 2015 in “Organogenesis” Wnt signaling is crucial for skin wound healing and reducing scars.
61 citations
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July 2011 in “PLOS ONE” Spermidine may help reduce hair loss and deserves further testing as a treatment.
22 citations
,
August 2020 in “Cells” TGM3 is important for skin and hair structure and may help diagnose cancer.
3 citations
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September 2023 in “Frontiers in immunology” Chronic inflammatory skin diseases are caused by disrupted interactions between skin cells and immune cells.
3 citations
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August 2012 in “Annals of Diagnostic Pathology” AIDS may cause changes in the scalp that increase infection risk and hair loss.
Current hair regeneration methods show promise but face challenges in maintaining cell effectiveness and creating the right environment for hair growth.
Melatonin may protect hair follicle stem cells from damage caused by chemotherapy.
Trichohyalin, a protein from pig tongue, was purified and found to have a filamentous structure.
47 citations
,
April 1978 in “Journal of Cutaneous Pathology” Basal cell epithelioma resembles fetal hair follicles, not adult or fetal skin.
August 2021 in “Annals of pathology and laboratory medicine” Most skin tumors in the study were benign, with squamous cell carcinoma being the most common malignant type.
26 citations
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March 2013 in “Journal of Biomedical Materials Research Part A” Researchers created a 3D hydrogel that mimics human hair follicles, which may help with hair loss treatments.
6 citations
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January 1990 in “The Journal of Dermatology” Human hair follicle cells can be grown successfully on floating collagen membranes without extra support.
3 citations
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July 1990 in “PubMed” Human hair follicles can grow and form structures in a collagen gel, useful for studying hair cell growth.
2 citations
,
February 2012 in “PubMed” Gp₄G promotes hair growth and improves skin health.
128 citations
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March 1989 in “Experimental Cell Research” Hoxc13 is important for hair and tongue development by controlling hair keratin genes.
40 citations
,
June 2013 in “Biomaterials” Scientists created 3D hair-like structures that could help study hair growth and test treatments.
4 citations
,
October 2017 in “Advances in tissue engineering & regenerative medicine” Researchers created a potential skin substitute using a biodegradable mat that supports skin cell growth and layer formation.
December 2015 in “OPAL (Open@LaTrobe) (La Trobe University)” QLT0267 stops hair follicle cell growth and movement.
158 citations
,
February 2012 in “Journal of Investigative Dermatology” FGF18 helps keep hair in its resting phase, affecting hair growth cycles.
4 citations
,
January 1991 in “PubMed” Different bovine tissues show varying types of cytokeratins.
111 citations
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June 2002 in “The EMBO Journal” Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.
5 citations
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September 2009 in “Acta Ophthalmologica” Hyper-keratinisation in Meibomian glands contributes to gland dysfunction.
May 2025 in “Proceedings of the National Academy of Sciences” UTX is crucial for skin differentiation and health, especially in females.
August 2018 in “Journal of Investigative Dermatology” Centrosomes are essential for healthy skin and hair growth, and their role is different from that of cilia.
January 2015 in “DukeSpace (Duke University)” Transferrin receptor 1 is essential for normal function in the intestines, pancreas, and skin.
December 1990 in “PubMed” Different glycoconjugates are present in the outer and inner root sheaths of human hair follicles.
November 2013 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Keratin 79 cells help form and regenerate hair canals.