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Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles

research Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles

14 citations , January 2017 in “Pharmacological Reports”

TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.

research Improved isolation of outer root sheath cells from human hair follicles and their proliferation behavior under serum-free condition

13 citations , February 2007 in “Biotechnology and Bioprocess Engineering”

research Epidermis reconstructed from the outer root sheath of human hair follicle on de-epidermized dermis. Effect of retinoic acid

August 1993 in “Journal of Dermatological Science”

Isolation and Characterization of Human Dental Tissue-Derived Stem Cells in Impacted Wisdom Teeth: Comparison of Dental Follicle, Dental Pulp, and Root Apical Papilla-Derived Cells

research Isolation and characterization of human dental tissue-derived stem cells in the impacted wisdom teeth: comparison of dental follicle, dental pulp, and root apical papilla-derived cells

9 citations , January 2010 in “Journal of the Korean Association of Oral and Maxillofacial Surgeons”

Root apical papilla cells from wisdom teeth are best for bone therapies.

research 597 Outer root sheath is able to synthesise glycogen from lactate-investigating glycogen metabolism in human hair follicles

7 citations , September 2019 in “Journal of Investigative Dermatology”

research Keratinization of outer root sheath cells is prevented by contact with inner root sheath of rat hair follicles

9 citations , July 2008 in “Archives of Dermatological Research”

research Some observations on the proteins of the inner root sheath cells of hair follicles

34 citations , July 1958 in “Biochimica et Biophysica Acta”

Ionizing Radiation Triggers Dedifferentiation of Outer Root Sheath Cells Into Stem Cell-Like Progenitors for Hair Follicle Regeneration

research 881 Ionizing radiation triggers dedifferentiation of outer root sheath cells into stem cell-like progenitors for hair follicle regeneration

April 2017 in “Journal of Investigative Dermatology”

research A Unique Type I Keratin Intermediate Filament Gene Family is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles

41 citations , January 2001 in “Journal of Investigative Dermatology”

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research Dermal-epidermal interactions—follicle-derived cell populations in the study of hair-growth mechanisms

19 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Dermal-epidermal interactions are crucial for hair growth and maintenance.

research Characterization of transport systems for cysteine, lysine, alanine, and leucine in wool follicles of sheep

9 citations , August 2007 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium”

Sheep wool follicles absorb different amino acids at various rates and locations, which could affect wool growth based on diet and genetics.

research Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

990 citations , October 1999 in “Development”

Activated LEF/TCF complexes are crucial for hair development and cycling.

research The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles

57 citations , April 2009 in “Differentiation”

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

research Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle

46 citations , November 1998 in “Experimental Cell Research”

K15 gene is mainly active in the basal layers of hair follicles and epithelia, aiding early skin cell development.

research Localization of the rabies virus antigen in Merkel cells in the follicle-sinus complexes of muzzle skins of rabid dogs

11 citations , September 2016 in “Journal of virological methods”

Rabies virus was found in specific skin cells of rabid dogs' muzzles, suggesting these cells could help diagnose rabies.

research Environment of the Anagen Follicle

4 citations , January 2018 in “Advances in Experimental Medicine and Biology”

The document concludes that hair follicles have a complex environment and our understanding of it is growing, but there are limitations when applying animal study findings to humans.

research The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region

2 citations , July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Proteolytic enzymes damaged hair follicle stem cells in transgenic mice.

research The location and proliferation of human hair follicle stem cells

January 2006 in “Chinese Journal of Dermatology”

Mesenchymal cells are essential for hair follicle stem cell growth.

research Nestin expression in hair follicle sheath progenitor cells

352 citations , August 2003 in “Proceedings of the National Academy of Sciences”

Nestin is found in hair follicle progenitor cells, linking them to neural stem cells.

research Regulation of hair follicle development by exosomes derived from dermal papilla cells

87 citations , April 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

research The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain

70 citations , December 2004 in “Differentiation”

The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.

research A Novel Type II Cytokeratin, mK6irs, is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

45 citations , March 2001 in “Journal of Investigative Dermatology”

A new protein, mK6irs, is found in specific hair layers and may help understand hair growth and diseases.

research Modulation of the differentiated phenotype of keratinocytes of the hair follicle and from epidermis

41 citations , July 1994 in “Journal of Dermatological Science”

Hair follicle cells need complex interactions to fully differentiate.

Transepidermal UV Radiation of Scalp Skin Ex Vivo Induces Hair Follicle Damage That Is Alleviated by Topical Treatment with Caffeine

research Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine

31 citations , February 2019 in “International Journal of Cosmetic Science”

Caffeine applied to the scalp can protect hair follicles from UV damage.

research CD34 glycoprotein identifies putative stem cells located in the isthmic region of canine hair follicles

21 citations , July 2006 in “Veterinary dermatology”

CD34 marks potential stem cells in dog hair follicles.

Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

research Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scalp

14 citations , October 2020 in “Scientific reports”

Hair greying is linked to reduced ATM protein in hair cells, which protects against stress and damage.

research Mesenchymal Stem Cells From Mouse Hair Follicles Reduce Hypertrophic Scarring in a Murine Wound Healing Model

13 citations , January 2022 in “Stem cell reviews and reports”

Mouse stem cells from hair follicles can improve wound healing and reduce scarring.

Quantification of Hair Follicle Parameters Using Computer Image Analysis: A Comparison of Androgenetic Alopecia with Normal Scalp Biopsies

research Quantification of hair follicle parameters using computer image analysis: A comparison of androgenetic alopecia with normal scalp biopsies

13 citations , August 1995 in “Australasian Journal of Dermatology”

Hair follicles are smaller in people with androgenetic alopecia compared to those with normal scalps.

research The Glypican-1/HGF/C-Met and Glypican-1/VEGF/VEGFR2 Ternary Complexes Regulate Hair Follicle Angiogenesis

10 citations , December 2021 in “Frontiers in cell and developmental biology”

Glypican-1 is important for blood vessel growth in hair follicles and could help treat hair loss.

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