180 citations
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January 2011 in “EMBO Reports” A combined approach is needed to fully understand adult stem cells, with genetic lineage-tracing being crucial.
141 citations
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May 2007 in “Cancer Research” CD34 is crucial for skin tumor development in mice.
129 citations
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July 2019 in “Stem Cell Research & Therapy” Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.
118 citations
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January 2016 in “Current Topics in Developmental Biology” The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.
87 citations
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March 2015 in “The EMBO Journal” Adult tissue stem cells can adapt and switch roles to help repair and maintain the body.
71 citations
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February 2020 in “Journal of Translational Medicine” Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.
65 citations
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January 2018 in “Nature Reviews Endocrinology” Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.
57 citations
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March 2019 in “Immunity” The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.
56 citations
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June 2015 in “Nature Protocols” Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.
27 citations
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June 2023 in “Nature” Senescent melanocytes can boost hair growth by activating hair stem cells.
21 citations
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October 2013 in “Molecular Biology of the Cell” The protein CCN2 controls hair growth by affecting hair follicle formation and stem cell activity in mice.
17 citations
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May 2021 in “Journal of Cell Science” N1-acetylspermidine promotes hair follicle stem cell self-renewal.
16 citations
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September 2020 in “Animals” circRNA-1926 helps goat stem cells turn into hair follicles by affecting miR-148a/b-3p and CDK19.
14 citations
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November 2020 in “International Journal of Molecular Sciences” Advanced therapies like gene, cell, and tissue engineering show promise for hair regrowth in alopecia, but their safety and effectiveness need more verification.
13 citations
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April 2022 in “Frontiers in oncology” Melanoma development can be linked to the breakdown of skin's melanin-producing units.
12 citations
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May 2014 in “International Journal of Molecular Medicine” Chrysanthemum zawadskii extract helps hair grow by stimulating hair cells.
11 citations
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October 2021 in “Stem Cell Research & Therapy” Hair follicle stem cells reduced hair loss and inflammation in mice with a condition similar to human alopecia.
11 citations
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June 2021 in “Frontiers in Cell and Developmental Biology” Melatonin helps goat hair stem cells grow and maintain their ability to become different cell types.
11 citations
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October 2016 in “Biomedicine & Pharmacotherapy” Both human platelet lysate and minoxidil can promote hair growth, but they affect different genes and cell survival rates.
10 citations
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June 2021 in “EMBO reports” When skin blisters, healing the wound is more important than growing hair, and certain stem cells mainly fix the blisters without helping hair growth.
10 citations
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October 2020 in “Frontiers in Cell and Developmental Biology” Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.
9 citations
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July 2020 in “Experimental Dermatology” Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.
7 citations
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May 2022 in “Frontiers in Cell and Developmental Biology” Epigenetic and metabolic changes affect stem cell function and aging in skin.
4 citations
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January 2025 in “The Journal of Cell Biology” Ceramide Synthase 4 is crucial for maintaining hair follicle stem cells and preventing hair loss.
4 citations
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April 2024 in “The Journal of Cell Biology” Caspase-1 helps hair stem cells move to heal wounded or inflamed skin.
3 citations
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January 2024 in “In Vivo” Methionine is essential for hair maintenance in C57BL/6 mice.
3 citations
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October 2023 in “Journal of Investigative Dermatology” Aged skin cells can help hair growth by stimulating stem cells.
3 citations
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July 2023 in “Frontiers in Aging” Hair follicle stem cells change states with age, affecting hair growth and aging.
3 citations
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December 2022 in “npj Regenerative Medicine” HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.
3 citations
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January 2019 in “Advances in stem cells and their niches” Dermal papilla cells are key for hair growth and color, influencing hair type and size, and their interaction with stem cells could help treat hair loss and color disorders.