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Did you mean Follicular Keratinocytes?

GlossaryFollicular Keratinocytes

specialized cells in hair follicles producing keratin for hair

Follicular keratinocytes are specialized cells found in hair follicles, the structures in the skin that produce hair. These cells are responsible for producing keratin, a protein that forms the structural foundation of hair. They play a crucial role in the growth and health of hair by continuously dividing and differentiating to form the hair shaft.

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research Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.

219 citations , July 1995 in “PubMed”

Keratinocyte growth factor promotes hair growth and reduces hair loss from chemotherapy.

Hair Growth Induction by the Tellurium Immunomodulator AS101: Association with Delayed Terminal Differentiation of Follicular Keratinocytes and Ras-Dependent Up-Regulation of KGF Expression

research Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression

51 citations , December 2003 in “The FASEB Journal”

The substance AS101 can help hair grow by slowing down hair cell aging and boosting a hair growth protein.

Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

research Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes

57 citations , June 2003 in “American Journal of Physiology-cell Physiology”

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

research Hair Growth Promoting Effects of Kesh-Kanti-Expert-Oil are Mediated Through Keratinocyte Proliferation and Modulation in Follicular Microenvironment

November 2025 in “Pharmacological Research - Natural Products”

Kesh Kanti Expert Oil promotes hair growth and protects hair health.

Conditioned Media Obtained from Human Outer Root Sheath Follicular Keratinocyte Culture Activates Signalling Pathways That Contribute to Maintenance of Hair-Inducing Capacity and Increases Trichogenicity of Cultured Dermal Cells

research Conditioned media obtained from human outer root sheath follicular keratinocyte culture activates signalling pathways that contribute to maintenance of hair-inducing capacity and increases trichogenicity of cultured dermal cells

6 citations , July 2012 in “Experimental Dermatology”

The substance from human hair root cells can help maintain hair growth and make skin cells more capable of growing hair.

research Regulation of PDGF and PDGF receptor in cultured dermal papilla cells and follicular keratinocytes of the human hair follicle

55 citations , September 2003 in “Experimental Dermatology”

PDGF signaling may play a role in hair growth cycle regulation.

research The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells

207 citations , July 2006 in “Development”

MTS24 marks a new type of skin cell that helps hair growth and repair.

research Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes

5 citations , October 2020 in “Frontiers in Cell and Developmental Biology”

Reducing FOXA2 in skin cells lowers their ability to grow hair.

Effects of Platelet-Rich Plasma on Hair Growth Using Artificial Intelligence-Based Trichoscopy and Ki67+ Keratinocytes Analysis: A Randomized Placebo-Controlled Trial

research Effects of Platelet-Rich Plasma on Hair Growth using Artificial Intelligence-based Trichoscopy and Ki67+ Keratinocytes Analysis: A Randomized Placebo-Controlled Trial

July 2025 in “Clinical Dermatology Review”

PRP significantly boosts hair growth in androgenic alopecia patients.

Expression of the L-Fucose Moiety on Infrainfundibular Follicular Keratinocytes of Terminal Follicles, Its Decreased Expression on Vellus and Indeterminate Follicles of Androgenetic Alopecia, and Re-Expression in Drug-Induced Hair Regrowth

research Expression of the L-Fucose Moiety on Infrainfundibular Follicular Keratinocytes of Terminal Follicles, Its Decreased Expression on Vellus and Indeterminate Follicles of Androgenetic Alopecia, and Re-Expression in Drug-Induced Hair Regrowth

9 citations , January 1992 in “Journal of Investigative Dermatology”

Sugar molecule helps hair growth, less in balding, returns with treatment.

research Enhancement of Hair Growth through Stimulation of Dermal Papilla Cells in Human Follicular Dermal

January 2018 in “Open access journal of pharmaceutical research”

Biofield Energy Healing may increase hair growth by enhancing cell proliferation.

Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression

research Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor β2 Expression

64 citations , March 2005 in “Journal of Investigative Dermatology”

Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.

research Hair Growth Promoting Effect of Radish Crude Saponin Extract on Athymic Nude Mice

March 2019 in “The International Journal of Advanced Smart Convergence”

Radish saponin extract may help grow hair in balding mice.

research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

34 citations , March 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research The epidermal growth factor receptor decreases Stathmin 1 and triggers catagen entry in the mouse

10 citations , December 2015 in “Experimental dermatology”

EGFR helps mouse hair follicles stop growing by reducing certain growth regulators.

research Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells

13 citations , December 2019 in “Nutrients”

An apple-based supplement was found to stimulate hair protein production, which may help with hair growth.

research Attenuation of Dickkopf 1-Induced Hair Growth Inhibition in Cultured Human Hair Follicles by Tianeptine

4 citations , January 2017 in “Annals of Dermatology”

Tianeptine may help prevent hair loss by promoting hair growth and reducing cell death.

research Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells

39 citations , December 2011 in “PLoS ONE”

Radiofrequency exposure can stimulate hair growth by increasing IGF-1 in hair follicle cells.

research Follicular Cell Implantation: An Emerging Cell Therapy for Hair Loss

13 citations , May 2005 in “Seminars in Plastic Surgery”

Follicular Cell Implantation might become a new treatment for hair loss and could lead to advances in organ regeneration.

research In vivoandIn vitrohair growth promotion effects of extract fromGlycine soja Siebold et Zucc

2 citations , June 2016 in “Journal of Applied Biological Chemistry”

Glycine soja extract stimulates hair growth and could help treat hair loss.

New Findings in Hair Research: Influence of Prolactin, Retinoids, and Transforming Growth Factor-β on Hair Growth

research Neues aus der Haarforschung: Einfluss von Prolaktin, Retinoiden und Transforming Growth Factor-β auf das Haarwachstum

3 citations , February 2005 in “Aktuelle Dermatologie”

Prolactin and TGF-β receptor blockers might help treat hair loss.

research Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin

37 citations , June 2019 in “Stem cells”

Special particles from skin cells can promote hair growth by activating a specific growth signal.

Exogenous Stimulation with Eclipta Alba Promotes Hair Matrix Keratinocyte Proliferation and Downregulates TGF-β1 Expression in Nude Mice

research Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice

24 citations , December 2014 in “International Journal of Molecular Medicine”

Eclipta alba extract helps increase hair growth and decrease hair loss-related protein in mice.

research Fibroblast Growth Factor-7 and Hair Biology: Bridging Basic Science and Therapeutic Applications

January 2026 in “Current Issues in Molecular Biology”

FGF-7 helps hair grow by activating hair follicles and is a promising target for hair loss treatments.

Follicular Dermal Papilla Structures by Organization of Epithelial and Mesenchymal Cells in Interfacial Polyelectrolyte Complex Fibers

research Follicular dermal papilla structures by organization of epithelial and mesenchymal cells in interfacial polyelectrolyte complex fibers

40 citations , June 2013 in “Biomaterials”

Scientists created 3D hair-like structures that could help study hair growth and test treatments.

research Beneficial effects of the conditioned medium of adipose tissue-derived stem cells on human follicular cells

January 2010 in “Seoul National University Open Repository (Seoul National University)”

The medium from stem cells in fat tissue may boost hair growth.

Melanogenesis Is Coupled to Murine Anagen: New Concepts for the Role of Melanocytes and Regulation of Melanogenesis in Hair Growth

research Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth.

109 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.

research Follicular cell implantation: Research update on “hair cloning”

October 2015 in “CRC Press eBooks”

Hair cloning for hair loss is not yet a practical solution.

Thymosin Beta 4 Increases Hair Growth by Activation of Hair Follicle Stem Cells

research Thymosin β₄increases hair growth by activation of hair follicle stem cells

98 citations , December 2003 in “The FASEB Journal”

Thymosin β4 promotes hair growth by activating stem cells in hair follicles.

research Vesicle Formation and Follicular Root Sheath Separation in Mice Homozygous for Deleterious Alleles at the Balding (bal) Locus

38 citations , September 1997 in “The journal of investigative dermatology/Journal of investigative dermatology”

A mutation in mice causes hair loss and skin issues due to a defect in a gene affecting cell adhesion.