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GlossaryFractional Lasers

target small skin areas to boost collagen and rejuvenation

Fractional lasers, also known as fractional laser therapy or fractional laser resurfacing, are a type of laser treatment that targets small, precise areas of the skin to promote collagen production and skin rejuvenation. By creating microscopic columns of treated skin surrounded by untreated tissue, these lasers help in faster healing and are commonly used for reducing wrinkles, scars, and pigmentation issues.

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A Randomized, Investigator-Blinded, Controlled, Split-Scalp Study of the Efficacy and Safety of a 1550-nm Fractional Erbium-Glass Laser, Used in Combination with Topical 5% Minoxidil Versus 5% Minoxidil Alone, for the Treatment of Androgenetic Alopecia

research A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia

29 citations , April 2019 in “Lasers in Medical Science”

Laser and minoxidil combo promotes better hair growth than minoxidil alone, safely.

research Histologic comparison of microscopic treatment zones induced by fractional lasers and radiofrequency

27 citations , August 2014 in “Journal of Cosmetic and Laser Therapy”

Different lasers and radiofrequency affect skin differently, important for dermatologists to choose the right treatment.

research Expression of collagen type I, skin fibroblasts and macrophages after 1550 nm erbium glass fractional laser in androgenic alopecia

January 2020

The 1550 nm fractional Er:Glass laser improved hair regrowth in patients with androgenic alopecia, but didn't significantly change collagen type I, skin fibroblasts, or macrophages. More research is needed for optimal results.

research Lasers in the management of alopecia: a review of established therapies and advances in treatment

April 2024 in “Lasers in medical science”

Lasers and light therapies are effective in promoting hair regrowth for different types of hair loss.

Alterations of Collagen Type 1, Skin Fibroblasts, and Macrophages in the Scalp Following the Treatment of 1550-nm Erbium Glass Fractional Laser for Androgenetic Alopecia

research Alterations of collagen type 1, skin fibroblasts, and macrophages in the scalp following the treatment of 1550‐nm erbium glass fractional laser for androgenetic alopecia

June 2021 in “Journal of Cosmetic Dermatology”

Laser treatment shows promise for hair growth, but needs further research.

Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

research Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

10 citations , August 2018 in “Dermatologic Surgery”

Laser treatment improves hair density and increases growth factors in androgenetic alopecia.

research Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models

24 citations , January 2016 in “Lasers in Medical Science”

Erbium glass laser treatment may help with skin remodeling, reduce inflammation, and improve skin cell maturation.

The Efficacy of 1550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

research 411 The efficacy of 1550-nm erbium-glass fractional laser treatment and its effect on the expression of insulin-like growth factor 1 and Wnt/β-catenin in androgenetic alopecia

April 2018 in “Journal of Investigative Dermatology”

Finasteride helps female-pattern hair loss.

research The effect of a 1550 nm fractional erbium-glass laser in female pattern hair loss

47 citations , August 2011 in “Journal of The European Academy of Dermatology and Venereology”

Laser treatment increases hair density and thickness safely in women with hair loss.

Comparative Study Between Topical Steroid Alone Versus Combined Fractional Erbium:YAG Laser With Topical Steroid In Treatment Of Alopecia Areata

research Comparative Study between Topical Steroid alone versus Combined Fractional Erbium:YAG laser with Topical Steroid in Treatment of Alopecia Areata

April 2022 in “Research Square (Research Square)”

The combination of laser and topical steroids is more effective for treating alopecia areata than topical steroids alone.

research Effectiveness and safety of the ablative fractional 2940-nm Er: YAG laser for the treatment of androgenetic alopecia

May 2024 in “Lasers in medical science”

The 2940-nm Er: YAG laser combined with medication is a safe and better treatment for male hair loss than medication alone.

research Evaluating the Efficacy of Platelet Rich Plasma and 1550 nm Fractional Laser in Combination and Alone for the Management of Androgenetic Alopecia

October 2022 in “Journal of Drugs in Dermatology”

Combining PRP and laser treatments improves hair density best for androgenetic alopecia.

research Laser therapies in androgenetic alopecia: Review and clinical experiences

January 2025 in “Journal of Cutaneous and Aesthetic Surgery”

Low-level laser therapy effectively improves hair growth in androgenetic alopecia with minimal side effects.

research A systematic review of erbium lasers in the treatment of androgenetic alopecia

May 2025 in “Lasers in Medical Science”

Erbium lasers improve hair growth in androgenetic alopecia with minimal side effects.

research 415 IL-17C: Checkpoint in innate skin immunology

April 2018 in “Journal of Investigative Dermatology”

IL-17C is important in inflammatory skin diseases and could be a target for treatment.

research 413 DC-HIL+ myeloid-derived suppressor cells are elevated in the peripheral blood and lesional skin of cutaneous lupus patients

April 2018 in “Journal of Investigative Dermatology”

Cutaneous lupus patients have higher levels of certain immune cells in their blood and skin.

Fractional CO₂ Laser Combined With Topical Compound Betamethasone for Vitiligo-Associated Leukotrichia: A Retrospective Study of 13 Patients With Limited Effectiveness

research Fractional CO₂ laser combined with topical compound betamethasone for Vitiligo-Associated Leukotrichia: a retrospective study of 13 patients with limited effectiveness

February 2026

The treatment showed limited success in repigmenting hair for vitiligo-associated leukotrichia.

research Enhancing hair follicle regeneration by nonablative fractional laser: Assessment of irradiation parameters and tissue response

16 citations , April 2015 in “Lasers in Surgery and Medicine”

Using a fractional laser can stimulate hair growth, but the intensity and duration of inflammation are crucial. Too much can cause ulcers and scarring. Lower beam energy and fewer treatments are recommended to avoid damage.

research Adverse events of non-ablative fractional laser photothermolysis: a retrospective study of 856 treatments in 362 patients

18 citations , May 2013 in “Journal of Dermatological Treatment”

Non-ablative fractional laser treatments have a low risk of side effects in Asian patients.

research Efficacy and safety of 1565-nm non-ablative fractional laser versus long-pulsed 1064-nm Nd:YAG laser in treating enlarged facial pores

4 citations , August 2022 in “Lasers in medical science”

Both 1565-nm laser and 1064-nm laser safely and effectively reduce enlarged facial pores, with the 1064-nm laser causing fewer side effects.

research Transcriptomic analysis of human skin wound healing and rejuvenation following ablative fractional laser treatment

24 citations , November 2021 in “PLoS ONE”

Ablative fractional laser treatment rejuvenates skin by altering gene expression and promoting wound healing and tissue regeneration.

research Rejuvenation of the male scalp using 1,927 nm non-ablative fractional thulium fiber laser

15 citations , January 2017 in “Lasers in Surgery and Medicine”

Laser treatment improved scalp skin condition with no side effects.

research Fractional resurfacing in the Asian patient: Current state of the art

33 citations , September 2016 in “Lasers in Surgery and Medicine”

Fractional resurfacing is safe and effective for certain skin conditions in Asian patients, but care must be taken to avoid skin pigmentation issues.

research Erbium YAG Laser in the Treatment of Androgenetic Alopecia

June 2022 in “International Journal of Biomedicine”

Erbium YAG laser treatment, combined with conventional therapy, can effectively reduce hair loss and promote hair growth in men with androgenetic alopecia.

Lasers in Dermatology: Advances and Applications

research Lasers in dermatology

3 citations , March 2008 in “Medical laser application”

Lasers have become safer and more effective for treating skin problems and hair removal.

research Erbium–Yttrium–Aluminum–Garnet Laser Irradiation Ameliorates Skin Permeation and Follicular Delivery of Antialopecia Drugs

31 citations , September 2014 in “Journal of Pharmaceutical Sciences”

Using a special laser can improve how well hair loss treatments get into the skin and hair follicles.

research Laser-assisted Hair Regrowth

5 citations , April 2019 in “Plastic and reconstructive surgery. Global open”

Fractional lasers could help hair regrowth in androgenic alopecia, but more research is needed to confirm their effectiveness and safety.

research Effect of fractional laser alone or in combination on alopecia areata: A systematic review and meta‐analysis

January 2023 in “Journal of cosmetic dermatology”

Fractional lasers effectively treat alopecia areata, especially when combined with minoxidil or cortisol.

research The rise of transcutaneous drug delivery for the management of alopecia: a review of existing literature and an eye towards the future

9 citations , October 2018 in “Journal of Cosmetic and Laser Therapy”

Using methods like lasers and microneedling with drugs can improve hair regrowth for alopecia, but more research is needed on safety and best practices.

research Nonablative Er:YAG Laser Treatment of Androgenetic Alopecia: A Clinical Observation

January 2025 in “Dermatologic Therapy”

The laser treatment improved hair appearance and was safe and well-received by patients.