research Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD
Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.
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30-60 / 1000+ results research Neurosteroid-sensitive δ-GABAAreceptors: A role in epileptogenesis?
Blocking neurosteroid production can lead to more seizures and faster epilepsy onset in rats.
research Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction
Neurosteroids may help metyrapone reduce cocaine addiction.
research Plasticity of GABAergic Inhibition
Targeting specific GABA receptors may help treat epilepsy and postpartum depression.
research NEW PROPRIETARY BRANDS: Gabapentin
Lifestyle changes are more effective than metformin for reducing type 2 diabetes risk.
research S.04.04 Social isolation alters GABAA receptors plasticity and function: effect of ethanol
research Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol
Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.
research Neonatal finasteride administration alters hippocampal α4 and δ GABAAR subunits expression and behavioural responses to progesterone in adult rats
research The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system
Crataeva nurvala leaves may help reduce anxiety and improve sleep.
research P.1.g.019 RY-023, an inverse agonist at alpha5 GABAA receptors: the influence on spatial memory and spontaneous locomotor activity
RY-023, a specific drug, can improve early stage memory learning without affecting general activity in rats, but it's less effective for later learning stages and doesn't impact memory recall.
research Mechanism of progesterone neuroprotection of rat cerebellar Purkinje cells following oxygen–glucose deprivation
Progesterone protects rat brain cells by enhancing GABA A receptor activity.
research The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches
Adjusting neurosteroid levels may help reduce alcohol withdrawal symptoms.
research Neurosteroids, neuroactive steroids, and symptoms of affective disorders
Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.
research Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice
AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.
research Inhibition of 5α‐Reduced Steroid Biosynthesis Impedes Acquisition of Ethanol Drinking in Male C57BL/6J Mice
Finasteride reduces alcohol consumption in mice by affecting brain chemicals.
research Isolation rearing-induced reduction of brain 5α-reductase expression: Relevance to dopaminergic impairments
Isolation stress in rats reduces brain enzyme levels, affecting dopamine function.
research In Search of New Therapeutics—Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond
New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.
research Effect of finasteride on behavioural arousal and somatosensory evoked potentials in fetal sheep
Finasteride may affect fetal brain development and increase arousal, but more research is needed for safety confirmation.
research Alterations in neonatal neurosteroids affect exploration during adolescence and prepulse inhibition in adulthood
Early-life neurosteroid changes affect adolescent exploration and adult behavior.
research Ethanol intake patterns in female mice: Influence of allopregnanolone and the inhibition of its synthesis
Female mice are less affected by certain substances that alter alcohol consumption compared to male mice.
research Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice
Progesterone's anesthetic effects don't rely on progesterone receptors.
research Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice
Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.
research Relationships between hair-follicle afferent axons and glycine-immunoreactive profiles in cat spinal dorsal horn
Aδ-LTMRs have complex synapses with glycine, while Aβ-LTMRs have simpler ones.
research Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model
A natural steroid in the body may protect against eye damage in glaucoma.
research Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy
Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.
research Inhibitory amino acid transmitters associated with axons in presynaptic apposition to cutaneous primary afferent axons in the cat spinal cord
Presynaptic inhibition of certain nerve fibers in cats is mainly controlled by GABA and glycine.
research Role of neurosteroids in the anticonvulsant activity of midazolam
Midazolam's seizure prevention is partly due to increased neurosteroid production.
research Olanzapine counteracts stress-induced anxiety-like behavior in rats
Olanzapine reduces stress-related anxiety in rats when given acutely.
research Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats
Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.
research Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling
Progesterone can reduce seizures without relying on the GABAA receptor pathway.