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Sinapic Acid and Glabridin Synergistically Mitigate Androgenetic Alopecia by Modulating Ferroptosis Through Stabilization of Beta-Catenin Against Ubiquitin-Dependent Degradation

research Sinapic acid and glabridin synergistically mitigate androgenetic alopecia by modulating ferroptosis through stabilization of β-catenin against ubiquitin-dependent degradation.

July 2025 in “PubMed”

Sinapic acid and glabridin together help hair growth in androgenetic alopecia.

research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1

28 citations , September 2000 in “Journal of Medicinal Chemistry”

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

research Non-competitive androgen receptor inhibition in vitro and in vivo

January 2010 in “Yearbook of Endocrinology”

Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.

research Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes

45 citations , August 2005 in “Bioorganic & medicinal chemistry”

New compounds with carborane showed anti-androgen effects similar to flutamide.

research Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation

53 citations , October 2011 in “Psychoneuroendocrinology”

Finasteride may help improve certain brain function issues linked to dopamine.

research Relative binding affinity of novel steroids to androgen receptors in hamster prostate

5 citations , January 2005 in “Journal of Enzyme Inhibition and Medicinal Chemistry”

New steroids were effective in blocking male hormone receptors in hamster prostates.

research Effects of transient receptor potential (TRP) channel agonists and antagonists on slowly adapting type II mechanoreceptors in the rat sinus hair follicle

13 citations , December 2009 in “Journal of the Peripheral Nervous System”

TRPA1 and TRPV1 channels don't affect mechanotransduction in rat sinus hair follicles.

Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

research Studies on Neurosteroids XXV. Influence of a 5.ALPHA.-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

61 citations , January 2008 in “Biological & Pharmaceutical Bulletin”

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

research The 5α-reductase inhibitor finasteride is not associated with alterations in sleep spindles in men referred for polysomnography

3 citations , October 2015 in “Human Psychopharmacology-clinical and Experimental”

Finasteride doesn't affect sleep spindles in men.

research GSK-3 Inhibitors: Recent Developments and Therapeutic Potential

3 citations , September 2008 in “Current signal transduction therapy”

Drugs that block GSK-3 show promise for treating various diseases.

research Neurosteroid allopregnanolone attenuates development of nicotine withdrawal behavior in mice

8 citations , February 2013 in “Neuroscience Letters”

Allopregnanolone may help prevent nicotine withdrawal symptoms.

research Towards the Development of AgoKirs: New Pharmacological Activators to Study Kir2.x Channel and Target Cardiac Disease

9 citations , August 2020 in “International Journal of Molecular Sciences”

New compounds may help treat heart disease by activating specific potassium channels.

research Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

36 citations , October 2015 in “Cell reports”

Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.

AGD1, A Class 1 ARF-GAP, Acts in Common Signaling Pathways with Phosphoinositide Metabolism and the Actin Cytoskeleton in Controlling Arabidopsis Root Hair Polarity

research AGD1, a class 1 ARF‐GAP, acts in common signaling pathways with phosphoinositide metabolism and the actin cytoskeleton in controlling Arabidopsis root hair polarity

56 citations , December 2011 in “The Plant Journal”

AGD1 is important for root hair development in Arabidopsis, working with phosphoinositide signaling and the actin cytoskeleton.

research Specific inhibition of FGF5-induced cell proliferation by RNA aptamers

15 citations , February 2021 in “Scientific Reports”

RNA aptamers can specifically block FGF5-related cell growth, potentially treating related diseases or hair disorders.

research Prodrugs of butyric acid from bench to bedside: Synthetic design, mechanisms of action, and clinical applications

70 citations , January 2000 in “Drug Development Research”

New butyric acid prodrugs show promise for cancer treatment, anemia management, and protecting hair from chemotherapy damage.

research Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice

29 citations , October 2009 in “Pharmacology Biochemistry and Behavior”

5alpha-Reductase Inhibitors Dampen L-DOPA-Induced Dyskinesia via Normalization of Dopamine D1-Receptor Signaling Pathway and D1-D3 Receptor Interaction

research 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction

26 citations , September 2018 in “Neurobiology of Disease”

Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.

research Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors

57 citations , May 2014 in “Molecular Phylogenetics and Evolution”

The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.

Effect of Allopregnanolone and Allotetrahydrodeoxycorticosterone on Spike-Wave Discharges in the EEG of Absence Epilepsy Rat Models

research Effect of the allopregnanolone and allotetrahydrodeoxycorticosteron on spike-wave discharges in the EEG of absence epilepsy rat models

4 citations , January 2018 in “General Physiology and Biophysics”

The steroids allopregnanolone and allotetrahydrodeoxycorticosteron worsened absence seizures in rats.

research Arabinogalactan proteins are involved in root hair development in barley

32 citations , December 2014 in “Journal of experimental botany”

Certain proteins are essential for the growth of root hairs in barley.

research Hair growth-modulation by adrenergic drugs

22 citations , August 1999 in “Experimental Dermatology”

Certain drugs can cause early hair growth in mice by affecting the nerves.

research Cerebellar Changes in Guinea Pig Offspring Following Suppression of Neurosteroid Synthesis During Late Gestation

9 citations , June 2016 in “The Cerebellum”

research The effects of finasteride (FIN) and thioacetamide (TAA) on acetylcholinesterase (AchE) activity in various brain regions.

December 2015 in “PLOS ONE”

research Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231

68 citations , January 2013 in “BMC Pharmacology and Toxicology”

Glibenclamide slows breast cancer cell growth by stopping cell division.

research Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro

6 citations , August 2019 in “PLOS ONE”

Gambogic Amide helps maintain hair color and promotes hair growth.

Discovery of (2S)-N-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-3-(6-(4-Cyanophenyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-Yl)-2-Hydroxy-2-Methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment

research Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment

December 2023 in “Journal of Medicinal Chemistry”

A new topical treatment for hair loss shows strong hair growth effects with low toxicity.

Pharmacokinetic Parameters and Mechanisms of Inhibition of Rat Type 1 and 2 Steroid 5α-Reductases: Determinants for Different In Vivo Activities of GI198745 and Finasteride in the Rat

research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.

22 citations , October 2001 in “Biochemical Pharmacology”

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

research Past and Future Strategies for GPCR Deorphanization

1 citations , July 2010

Finding functions for unknown GPCRs is hard but key for making new drugs.

research Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain

61 citations , September 2011 in “Pain”

PEA reduces pain by increasing neurosteroid synthesis in the spinal cord.

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