research Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice
AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.
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150-180 / 885 resultsresearch Social isolation‐induced increase in α4and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABAAreceptor function
Social isolation makes rats more sensitive to alcohol's effects on the brain.
research Isolation rearing-induced reduction of brain 5α-reductase expression: Relevance to dopaminergic impairments
Isolation stress in rats reduces brain enzyme levels, affecting dopamine function.
research Effect of finasteride on behavioural arousal and somatosensory evoked potentials in fetal sheep
Finasteride may affect fetal brain development and increase arousal, but more research is needed for safety confirmation.
research Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model
A natural steroid in the body may protect against eye damage in glaucoma.
research Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy
Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.
research Role of neurosteroids in the anticonvulsant activity of midazolam
Midazolam's seizure prevention is partly due to increased neurosteroid production.
research Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats
Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.
research Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling
Progesterone can reduce seizures without relying on the GABAA receptor pathway.
research The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice
Neurosteroids in the brain can increase or decrease seizure risk in mice.
research A high-performance liquid chromatography–tandem mass spectrometry assay of the androgenic neurosteroid 3α-androstanediol (5α-androstane-3α,17β-diol) in plasma
Testosterone increases 3α-androstanediol levels, which can be blocked by finasteride.
research 11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis
11β-Hydroxylase inhibitors help prevent seizures in mice by boosting natural neurosteroid production.
research Possible involvement of 5α-reduced neurosteroids in adrenergic and serotonergic stimulation of GFAP gene expression in rat C6 glioma cells
5α-reduced neurosteroids may help regulate glial cell differentiation.
research Investigation of the mechanisms of progesterone protection following oxygen–glucose deprivation in organotypic hippocampal slice cultures
Progesterone protects brain cells by converting to allopregnanolone and involving GABAA receptors.
research Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model
A brain-produced steroid causes increased scratching in mice with a skin condition similar to eczema.
research Mitochondrial dysfunction in diabetic neuropathy may be involved in the development of neuropathic pain via a reduction in neurosteroid synthesis
Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.
research Implications of neuroimaging for the treatment of epilepsy
Neuroimaging suggests that treatments targeting brain steroids could help control epilepsy, especially types linked to the menstrual cycle.
research ABSTRACTS—SYMPOSIA
Certain drugs can block changes in brain receptors caused by alcohol withdrawal.
research Hormones and Absence Epilepsy☆
Stress and hormones like progesterone can affect absence seizures, but their effects change with different life stages.
research Pregnancy's lasting imprint: Late pregnancy allopregnanolone alters rat fear recall and medial prefrontal cortex activity
Pregnancy affects fear memory and brain activity in female rats.
research Lactium: A Novel Drug for Psychocutaneous Skin Disorders
Lactium, a milk protein, can help reduce symptoms of skin disorders linked to stress and anxiety without side effects.
research Neurosteroids as Endogenous Regulators of Seizure Susceptibility
Stress increases neurosteroids that help prevent seizures.
research Benzothiazepines, diltiazem and JTV-519, exert an anxiolytic-like effect via neurosteroid biosynthesis in mice
Benzothiazepines like diltiazem reduce anxiety in mice by making neurosteroids.
research Roles of Type 10 17beta-Hydroxysteroid Dehydrogenase in Intracrinology and Metabolism of Isoleucine and Fatty Acids
This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.
research Finasteride treatment and neuroactive steroid formation.
Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.
research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System
Testosterone and its metabolites affect brain functions and could help treat neurological disorders.
research The neurosteroid metabolite of progesterone, 3α‐OH‐dihydroprogesterone (3α‐OH‐DHP), is required for attenuated baroreflex mediated sympathoexcitation in pregnancy
3α‐OH‐DHP is essential for reducing nerve activity related to blood pressure control during pregnancy.
research Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies
Different rat and mouse strains respond differently to stress and alcohol, which may help us understand similar human mechanisms.
research Neuroactive Steroids: Functions, Mechanisms of Action and Physiologic Relevance
Allopregnanolone may enhance alcohol's effects on dopamine neurons, influencing addiction risk.
research Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABAAReceptor Function and Seizure Susceptibility
Stress increases neurosteroids that help prevent seizures.