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Identification of Dual-Purpose Therapeutic Targets Implicated in Aging and Glioblastoma Multiforme Using PandaOmics - An AI-Enabled Biological Target Discovery Platform

research Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform

17 citations , April 2023 in “Aging”

CNGA3, GLUD1, and SIRT1 are promising targets for treating aging and glioblastoma.

research Hutchinson-Gilford progeria syndrome - A brief introduction

2 citations , June 2018 in “International Journal of Pharmacological Research”

Hutchinson-Gilford Progeria Syndrome caused rapid aging due to a genetic mutation, with treatments to manage symptoms.

research Abstract C4: Sp2: A regulator of stem cell differentiation and tumorigenesis

December 2009 in “Cancer Research”

Over-expression of Sp2 can lead to cancer by preventing proper stem cell differentiation.

research Identification of differentially expressed Gnαs and Gnα11 in sheep ( Ovis aries ) skins associated with white and black coat colors

1 citations , January 2016 in “Acta histochemica”

Black sheep have higher levels of Gnαs and Gnα11 proteins, which may affect their coat color.

Multi-View Light Sheet Fluorescence Microscopy for Imaging Cellular Self-Assembly in Spheroids of Human Hair Follicle Dermal Papilla Cells and Keratinocytes

research 812 Multi-view light sheet florescence microscopy (LSFM) for imaging cellular self-assembly in spheroids of human hair follicle dermal papilla cells and keratinocytes

June 2020 in “Journal of Investigative Dermatology”

The technique effectively shows how human skin and hair cells form into ball-like structures.

The Effect of Topical Gel Secretome Hypoxic Mesenchymal Stem Cells on IL-6 and TGF-β Gene Expression in Male Wistar Alopecia-Like Rat Models Induced by Fluconazole

research The Effect of Topical Gel Secretome Hypoxic Mesenchymal Stem Cells (SH-MSCs) on IL-6 and TGF- β Gene Expression (Experimental Study in Male Wistar Alopecia-Like Rat Models Induced by Fluconazole)

December 2023 in “International journal of multidisciplinary research and analysis”

SH-MSCs gel reduced IL-6 and increased TGF-β, suggesting it could treat alopecia.

research Rare Gli1+ perivascular fibroblasts promote skin wound repair

2 citations , May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Rare Gli1+ fibroblasts are crucial for skin wound healing.

research The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function

3 citations , May 2022 in “Oncogene”

Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.

research Plant elicitor Peptides regulate root hair development in Arabidopsis

February 2024 in “Frontiers in plant science”

Peps help Arabidopsis plants grow more root hairs by affecting specific genes and calcium signaling.

research Calcium Regulation of Growth, Differentiation and Keratinization of Cultured Cells from Murine Hair and Hair Follicles : An Ultrastructural Study

3 citations , December 1990 in “Acta Medica et Biologica”

research WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation

18 citations , January 2013 in “Journal of Investigative Dermatology”

WIF1 helps keep skin stem cells inactive to prevent excessive cell growth.

research TGF-β2 and collagen play pivotal roles in the spheroid formation and anti-aging of human dermal papilla cells

11 citations , August 2021 in “Aging”

Collagen and TGF-β2 help maintain hair cell shape and youthfulness.

research Characterization and Localization of Side Population Cells in Mouse Skin

89 citations , May 2005 in “Stem Cells”

Mouse skin has special cells in the epidermis that decrease with age and are linked to keratinocyte stem cells.

research Biochemistry of Transglutaminases and Cross-Linking in the Skin

57 citations , July 1983 in “Journal of Investigative Dermatology”

Facile Strategy for Gelatin-Based Hydrogel with Multifunctionalities to Remodel Wound Microenvironment and Accelerate Healing of Acute and Diabetic Wounds

research Facile strategy for gelatin-based hydrogel with multifunctionalities to remodel wound microenvironment and accelerate healing of acute and diabetic wounds

November 2023 in “International Journal of Biological Macromolecules”

The gelatin-based hydrogel helps heal acute and diabetic wounds faster by improving healing conditions.

research Suprabasal change and subsequent formation of disulfide-stabilized homo- and hetero-dimers of keratins during esophageal epithelial differentiation

28 citations , March 1993 in “Journal of Cell Science”

Keratins K4 and K13 form stable dimers in mature esophageal cells, aiding cell stability.

research Arabidopsis ZINC FINGER PROTEIN1 Acts Downstream of GL2 to Repress Root Hair Initiation and Elongation by Directly Suppressing bHLH Genes

101 citations , November 2019 in “The Plant Cell”

AtZP1 protein stops root hair growth in plants by blocking certain genes.

research Bioinspired peptides designed for hair perming and dyeing with potential for repair

3 citations , July 2023 in “Acta Biomaterialia”

PepACS offers a safer, eco-friendly way to perm, dye, and repair hair.

research EFFECT OF GELATIN-CYSTINE AND SERENOA REPENS EXTRACT ON FREE RADICALS LEVEL AND HAIR GROWTH

6 citations , January 1998 in “Journal of applied cosmetology”

research Identification of the keratin-associated protein 13-3 (KAP13-3) gene in sheep

26 citations , January 2011 in “Open Journal of Genetics”

The KAP13-3 gene in sheep affects wool quality by influencing keratin assembly.

Updated Skin Transcriptomic Atlas Depicted by Reciprocal Contribution of Single-Nucleus RNA Sequencing and Single-Cell RNA Sequencing

research 1347 Updated skin transcriptomic atlas depicted by reciprocal contribution of single-nucleus RNA sequencing and single-cell RNA sequencing

April 2023 in “Journal of Investigative Dermatology”

The research updated the skin cell profile, finding new skin cell markers and showing fibroblasts' key role in skin health.

research The RAIG Family Member, GPRC5D, Is Associated with Hard-Keratinized Structures

64 citations , March 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

GPRC5D is linked to the formation of hair, nails, and certain tongue areas.

research LncRNA018392 promotes the proliferation of Liaoning cashmere goat skin fibroblasts by upregulating CSF1R through binding to SPI1

3 citations , August 2024 in “Molecular Biology Reports”

LncRNA018392 helps goat skin cells grow by increasing CSF1R.

research Integrated Lipidomics in the Secreted Phospholipase A2 Biology

11 citations , February 2011 in “International Journal of Molecular Sciences”

Different sPLA2 enzymes have unique roles in phospholipid metabolism and biological processes.

research Simultaneous Typing of Erythrocyte Acid Phosphatase, Adenylate Kinase and Adenosine Deaminase in Human Hair Root Sheaths

1 citations , September 1986 in “Journal of the Forensic Science Society”

Hair root sheaths can be used to accurately analyze genetic markers.

research Spatiotemporal Expression Characterization of KRTAP6 Family Genes and Its Effect on Wool Traits

January 2024 in “Genes”

KRTAP6 genes affect wool quality in sheep.

research Skin tumors with matrical differentiation: lessons from hair keratins, beta‐catenin and PHLDA‐1 expression

47 citations , February 2014 in “Journal of Cutaneous Pathology”

Matrical tumors share a common growth mechanism involving the Wnt pathway and consistent PHLDA1 expression.

research LncRNA MTC enhances the proliferation of Liaoning cashmere goat skin fibroblasts by modulating GSTM1-ASK1 interaction

March 2024 in “Cytologia”

LncRNA MTC boosts growth of goat skin cells, improving cashmere quality.

research Parallels in signaling between development and regeneration in ectodermal organs

8 citations , January 2022 in “Current topics in developmental biology/Current Topics in Developmental Biology”

research HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation

20 citations , December 2019 in “International Journal of Molecular Sciences”

HB-EGF boosts the hair growth ability of stem cells, making it a potential hair loss treatment.

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