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research Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter

215 citations , November 2000 in “Journal of Investigative Dermatology”

The system allows precise control of gene expression in mouse skin, useful for studying skin biology.

research Keratin gene mutations in disorders of human skin and its appendages

185 citations , December 2010 in “Archives of Biochemistry and Biophysics”

Keratin gene mutations cause various skin and hair disorders, but new research offers hope for future treatments.

Vestibular Hair Cell Regeneration and Restoration of Balance Function Induced by Math1 Gene Transfer

research Vestibular Hair Cell Regeneration and Restoration of Balance Function Induced by Math1 Gene Transfer

129 citations , January 2007 in “Otology & Neurotology”

Gene therapy with the Math1 gene helped regenerate balance-related cells and improve balance in mice.

research Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair

119 citations , August 2008 in “BMC Evolutionary Biology”

KRTAP genes evolved early in mammals, leading to diverse hair traits.

research Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans

114 citations , August 2002 in “Journal of Investigative Dermatology”

Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.

The Proximal Promoter of the Human Transglutaminase 3 Gene

research The Proximal Promoter of the Human Transglutaminase 3 Gene

105 citations , February 1996 in “Journal of biological chemistry/The Journal of biological chemistry”

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations , June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

research Regulation of Keratin Gene Expression in Hair Follicle Differentiation^a

98 citations , December 1991 in “Annals of the New York Academy of Sciences”

Keratin gene regulation is similar across mammals, affecting hair follicle differentiation.

research Gene expression profiling gets to the root of human hair follicle stem cells

92 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.

Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss

research Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss

77 citations , April 2009 in “British Journal of Dermatology”

Aromatase gene variation may increase female hair loss risk.

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