May 2026 in “RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218” This review analyzes recent scientific evidence on the neuroendocrine and metabolic impacts of chronic use of 5-alpha reductase inhibitors, focusing on Post-Finasteride Syndrome (PFS). The study, based on eight high-impact studies from 2021 to 2026, highlights PFS as a multisystemic condition linked to the use of 5-ARIs, with reports of refractory sexual dysfunction and mood disorders in young patients. The inhibition of enzymes in the central nervous system suppresses the synthesis of active metabolites like allopregnanolone, leading to GABAergic dysregulation and excitotoxicity. Metabolically, the suppression of dihydrotestosterone is associated with insulin resistance, non-alcoholic fatty liver disease, Type 2 Diabetes Mellitus, and changes in gut microbiota. Genetic polymorphisms in the SRD5A2 gene and epigenetic changes, such as DNA methylation of the androgen receptor, contribute to the chronicity of symptoms. The findings suggest that PFS extends beyond transient side effects, emphasizing the need for personalized medicine models and strengthened informed consent protocols to mitigate persistent biopsychosocial risks.
Frontal fibrosing alopecia in men is often misdiagnosed and needs better diagnostic criteria and treatments.
December 2024 in “Reports of Vinnytsia National Medical University” Men with alopecia areata have different body proportions, with shorter legs and longer upper bodies.
January 2024 in “JCEM case reports” This is the first known case of parathyroid cancer in a patient with Birt Hogg Dube Syndrome.
January 2021 in “Journal of the European Academy of Dermatology and Venereology” PrEP doesn't increase STI risk in high-risk men, anti-androgen drugs may lower ICU admission for male COVID-19 patients, a 3-point injection is better for crow's feet, and the 'Geriatric-8' tool could help assess frailty in older skin cancer patients.
January 2018 in “Springer eBooks” Alopecia totalis/universalis is a severe form of hair loss where all body hair is lost.
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists created a new 3D skin model from cells of plucked hairs that works like real skin and is easier to get.
September 2012 in “Annals of saudi medicine/Annals of Saudi medicine” The twins' condition is unique and doesn't match any known syndromes.
June 2011 in “Expert Review of Dermatology” Researchers discovered potential origins and new treatments for skin cancer, including biomarkers for melanoma and therapies that reduce tumor growth.
October 2007 in “Clinical Biochemistry” New genotype linked to non-classical congenital adrenal hyperplasia found in Italian siblings.
October 1997 in “Dermatologic Clinics” The aging population's demand for aesthetic medicine is increasing due to longer life expectancy and societal factors.
15 citations
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May 2003 in “Choice Reviews Online” Many health beliefs are myths; evidence-based medicine is crucial.
July 2025 in “Journal of Investigative Dermatology” Machine learning can help identify biomarkers for personalized Pemphigus vulgaris treatment.
January 2006 in “Fertility and Sterility” The book provides a detailed guide on managing Polycystic Ovary Syndrome and is useful for physicians.
15 citations
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February 2015 in “Cell & tissue research/Cell and tissue research” P-cadherin is important for hair growth and health, and its problems can cause hair and skin disorders.
9 citations
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March 2009 in “Psychoneuroendocrinology” Certain gene variations are linked to better memory in healthy Chinese women.
2 citations
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December 2004 in “Medicine” Different hair and scalp disorders cause hair loss or excess hair growth, with various treatments available depending on the specific condition.
July 2023 in “The Egyptian Journal of Hospital Medicine ” Alopecia areata is a hair loss condition caused by immune factors and can be treated with JAK inhibitors.
May 2023 in “IntechOpen eBooks” More research is needed to understand how testosterone is maintained in adult males.
August 2015 in “Free Radical Biology and Medicine” The study suggests that higher levels of SIRT1 and SIRT2 may improve overall cell health and aging processes.
1 citations
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August 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” A new mutation in the TMEM173 gene and a risk allele in IFIH1 cause a unique set of immune-related symptoms.
May 2022 in “Journal of the Egyptian Women's Dermatologic Society (Print)” Women's hair loss can be due to hormonal changes and various conditions, with treatments focusing on stopping progression and managing symptoms.
July 2023 in “Nature Genetics” Researchers identified key cell types and genes involved in hair and skin diseases.
13 citations
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January 2013 in “Molecular genetics and metabolism” Proper diet management is crucial for phenylketonuria patients to avoid severe health issues.
3 citations
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January 2018 in “Archives of Disease in Childhood” Switching to generic tacrolimus was safe, effective, and saved money.
36 citations
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September 2015 in “Orphanet Journal of Rare Diseases” Revertant cell therapy could be a future treatment for Ichthyosis with confetti.
24 citations
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November 2015 in “Frontiers in Genetics” Nitroxide drugs can safely and effectively treat age-related diseases like macular degeneration and cardiovascular issues.
175 citations
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August 1997 in “Nature Genetics” 2 citations
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October 2021 in “Skin health and disease” No significant link between male pattern baldness and COVID-19 severity was found.
47 citations
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July 2023 in “Nature Genetics”