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Faculty Opinions Recommendation of Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

research Faculty Opinions recommendation of Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

June 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Six new risk spots for early hair loss were found, which also link to Parkinson's disease and lower fertility. Two genes, FOXA2 and HDAC4, could be new treatment targets. Hair loss might also be connected to heart disease, metabolic syndrome, and prostate cancer.

research Association of atopic dermatitis with autoimmune diseases: A bidirectional and multivariable two-sample mendelian randomization study

12 citations , March 2023 in “Frontiers in immunology”

Atopic dermatitis increases the risk of some autoimmune diseases.

Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

research Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified

18 citations , February 2012 in “Experimental Dermatology”

No link found between specific genes and female pattern hair loss.

research A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

196 citations , March 2016 in “Nature Communications”

Genetic factors influence hair traits like shape, color, and greying in Latin Americans.

research Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations

58 citations , June 2018 in “Scientific reports”

Researchers found 15 new genetic links to skin traits in Japanese women.

research Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men

78 citations , August 2012 in “Human molecular genetics online/Human molecular genetics”

A new gene, JMJD1C, may affect testosterone levels in men.

research Genome‐wide association study identifies variants associated with hair length in Brangus cattle

9 citations , June 2020 in “Animal genetics”

Scientists found genes linked to hair length in Brangus cattle that could help breed heat-tolerant cattle.

research Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles

1 citations , September 2023 in “Clinical, cosmetic and investigational dermatology”

Certain genetic variants linked to immune response increase the risk of alopecia areata in Taiwanese people.

research The Genetics of Seborrheic Dermatitis: A Candidate Gene Approach and Pilot Genome-Wide Association Study

15 citations , December 2017 in “Journal of Investigative Dermatology”

No strong genetic link to other skin conditions was found, but some genetic factors may make people more likely to get seborrheic dermatitis.

research Understanding autoimmunity of vitiligo and alopecia areata

74 citations , May 2016 in “Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics”

Both vitiligo and alopecia areata involve an immune response triggered by stress and specific genes, with treatments targeting this pathway showing potential.

Genome Wide Association Analysis of Root Hair Traits in Rice Reveals Novel Genomic Regions Controlling Epidermal Cell Differentiation

research Genome wide association analysis of root hair traits in rice reveals novel genomic regions controlling epidermal cell differentiation

2 citations , January 2023 in “BMC plant biology”

Scientists found new genetic areas that affect how rice root hairs grow and develop.

research Genome-wide association study of atopic and autoimmune comorbidities in alopecia areata

April 2026 in “Frontiers in Immunology”

Certain genes may be linked to autoimmune conditions in people with alopecia areata.

research Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

717 citations , June 2010 in “Nature”

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

research Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability

94 citations , April 2018 in “Nature Genetics”

New genetic locations explain much of hair color variation in Europeans.

research Genome-wide association study for cashmere traits in Inner Mongolia cashmere goat population reveals new candidate genes and haplotypes

13 citations , July 2024 in “BMC Genomics”

New genes and markers can help breed better cashmere goats.

research Genome-Wide Association Study and Transcriptome Differential Expression Analysis of the Feather Rate in Shouguang Chickens

2 citations , December 2020 in “Frontiers in genetics”

Researchers found genes linked to feather growth speed in Shouguang chickens, highlighting two genes that might explain differences in feathering.

research Genome-Wide Association Study of Fiber Diameter in Alpacas

1 citations , October 2023 in “Animals”

Certain DNA regions in alpacas are linked to fiber diameter.

research Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation

3 citations , April 2023 in “Veterinary sciences”

Researchers found genes that may explain why some pigs grow winter hair, which could help breed cold-resistant pigs.

research A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients

32 citations , September 2013 in “Breast cancer research”

A specific gene variant is linked to a higher risk of hair loss from chemotherapy in breast cancer patients.

research Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2

29 citations , June 2016 in “Experimental Dermatology”

MCHR2 gene duplications may be linked to alopecia areata.

research Finding bald spots on chromosome 20p11

1 citations , February 2009 in “Clinical Genetics”

New genes linked to male pattern baldness were found on chromosome 20p11.

research Association between genetically predicted rheumatoid arthritis and alopecia areata: a two-sample Mendelian randomization study

2 citations , October 2023 in “Frontiers in Immunology”

People with rheumatoid arthritis have a higher risk of developing alopecia areata.

research Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study

April 2024 in “Human genomics”

Identified genes linked to male-pattern baldness may help develop new treatments.

research Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

87 citations , May 2012 in “PLOS Genetics”

Six new genetic regions linked to early hair loss also connect to Parkinson's disease and prostate cancer, possibly leading to new treatments.

research LB1053 Dysregulation of antioxidant enzyme PRDX5 in alopecia areata

1 citations , August 2019 in “Journal of Investigative Dermatology”

PRDX5 enzyme may contribute to alopecia areata by affecting oxidative stress and autoimmunity.

research Genomic Analysis of Trichotillomania

1 citations , January 2025 in “medRxiv”

Trichotillomania may have a genetic link to psychiatric disorders.

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