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Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo

research Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo

February 2026 in “International Journal of Molecular Sciences”

Silencing SFRP1 alone promotes hair growth, but adding DKK1 does not help.

research IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

February 2024 in “Experimental Dermatology”

IGFBP-rP1 could be a new treatment for a common type of hair loss.

research Janus kinase inhibition for the treatment of refractory frontal fibrosing alopecia: A case series and review of the literature

16 citations , August 2023 in “JAAD Case Reports”

JAK inhibitors, like ruxolitinib, may effectively treat frontal fibrosing alopecia.

research Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

265 citations , March 1993 in “The EMBO Journal”

Keratinocyte growth factor significantly alters skin and tissue development.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

Discovery of (2S)-N-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-3-(6-(4-Cyanophenyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-Yl)-2-Hydroxy-2-Methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment

research Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment

December 2023 in “Journal of Medicinal Chemistry”

A new topical treatment for hair loss shows strong hair growth effects with low toxicity.

research Engineered Exosomes Co-Delivering EGF and FGF Ameliorate Androgenetic Alopecia in a Mouse Model

February 2026 in “SHILAP Revista de lepidopterología”

Engineered exosomes with EGF and FGF improve hair growth in mice with hair loss.

research 270 A novel small compound HPH-15 antagonizes TGF-β/Smad signaling and ameliorates experimental skin fibrosis

April 2017 in “Journal of Investigative Dermatology”

HPH-15, a new compound, effectively reduces skin fibrosis in experiments without causing harm.

Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia by Activating Hair Follicle Stem Cells

research Progenic hair regrowth treatment- The use of platelet-released growth factors for treating androgenetic alopecia (AGA) by activating hair follicle stem cells

August 2014 in “Journal of clinical & experimental dermatology research”

Platelet-released growth factors can treat hair loss by activating hair follicle stem cells, blocking certain pathways, and controlling inflammation and fibrosis.

research Frontal fibrosing alopecia treatment options

20 citations , January 2016 in “Intractable & Rare Diseases Research”

Combination therapy, especially with finasteride, is effective for treating frontal fibrosing alopecia.

research Glutamic acid promotes hair growth in mice

12 citations , July 2021 in “Scientific Reports”

Glutamic acid helps increase hair growth in mice.

research Pharmacological Application of Growth Factors: Basic and Clinical

2 citations , January 2015 in “BioMed Research International”

Growth factor treatments are increasingly used in medicine but require more research to fully understand their mechanisms.

research Female Androgenetic Alopecia: An Update on Diagnosis and Management

43 citations , November 2019 in “American Journal of Clinical Dermatology”

FAGA diagnosis uses blood tests and trichoscopy, with treatments like topical minoxidil, oral anti-androgens, and hormone-modulating drugs.

research Unexpected hair growth induced by gefitinib treatment in two patients with EGFR gene mutation-positive adenocarcinoma of the lung

1 citations , September 2015

Gefitinib treatment led to unexpected hair growth in two lung cancer patients.

research Stimulation of mouse vibrissal follicle growth by recombinant human fibroblast growth factor 20

4 citations , April 2018 in “Biotechnology Letters”

Human growth factor 20 can boost mouse whisker growth.

research 0953 Double knockdown of DKK1 and SFRP1, two key players in androgenetic alopecia, does not accelerate the hair-growth promoting effect of individual SFRP1 knockdown in healthy human hair follicles ex vivo

July 2025 in “Journal of Investigative Dermatology”

research Jagged1 and Epidermal Growth Factor Promoted Androgen-Suppressed Mouse Hair Growth In Vitro and In Vivo

7 citations , January 2020 in “Frontiers in Pharmacology”

Jagged1 and Epidermal Growth Factor together significantly increased hair growth in mice with androgen-suppressed hair.

FGF7-Dependent Inhibition of Human Hair Growth by an Osteopontin-Derived Peptide: A Novel Solution for Hirsutism and Hypertrichosis

research 1371 FGF7-dependent inhibition of human hair growth byan osteopontin-derived peptide: A novel solution for hirsutism and hypertrichosis?

April 2018 in “Journal of Investigative Dermatology”

A new peptide, FOL-005, may help treat excessive hair growth by reducing a hair growth promoter, FGF7.

research Fibroblast Growth Factor Influences the Development and Cycling of Murine Hair Follicles

58 citations , April 1993 in “Developmental Biology”

bFGF delays hair growth in mice.

research Epidermal growth factor precursor retards hair growth cycle in vivo

January 2001

Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

research Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process

27 citations , February 2017 in “Clinical, Cosmetic and Investigational Dermatology”

New compounds were found to help increase hair growth and decrease hair loss.

research Amphiregulin in Fibrotic Diseases and Cancer

2 citations , June 2025 in “Preprints.org”

Targeting amphiregulin may improve treatment for fibrotic diseases and cancer.

research Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson–Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies

4 citations , May 2023 in “Cells”

Baricitinib and its combination with lonafarnib improve fat cell formation in certain genetic disorders.

research Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells

10 citations , January 2020 in “Acta Neurobiologiae Experimentalis”

Valproic acid and crocin together boost cell growth and may help treat nerve injuries.

research RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells

6 citations , October 2024 in “Frontiers in Bioengineering and Biotechnology”

A special hydrogel helps stem cells heal wounds better by boosting growth factors.

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