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Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

research Faculty Opinions recommendation of Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.

May 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Prostaglandin D2, found in higher levels in bald scalps, stops hair growth, suggesting that blocking its receptor could potentially treat hair loss.

research Prostaglandin D ₂ Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

research Computer-Aided Designing Peptide Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase Combined Molecular Docking and Molecular Dynamics Simulation

9 citations , August 2023 in “Molecules”

Two peptides, RMYYY and VMYMI, may be effective anti-inflammatory drugs.

research Hypertrichosis of the malar areas and poliosis of the eyelashes caused by latanoprost

5 citations , July 2014 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas”

Latanoprost eye drops caused excessive hair growth and eyelash whitening in a woman.

research Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis

1 citations , March 2023 in “Science Translational Medicine”

Blocking a certain signal in the gp130 receptor can improve tissue healing and lessen osteoarthritis symptoms.

Cardamonin-Loaded Liposomal Formulation for Improving Percutaneous Penetration and Follicular Delivery for Androgenetic Alopecia

research Cardamonin-loaded liposomal formulation for improving percutaneous penetration and follicular delivery for androgenetic alopecia

February 2024 in “Drug Delivery and Translational Research”

A new liposomal formulation improves drug delivery and hair growth for treating hair loss without causing skin irritation.

Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

research Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process

27 citations , February 2017 in “Clinical, Cosmetic and Investigational Dermatology”

New compounds were found to help increase hair growth and decrease hair loss.

research Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique

1 citations , January 2024 in “NPJ breast cancer”

Experts agree on how to manage sugar levels and skin reactions in patients taking the cancer drug alpelisib.

research Discovery of an Androgen Receptor Degrader Featuring a Pyridazinyl Glutarimide CRBN-Binding Motif for Transdermal Treatment of Androgenetic Alopecia

May 2026 in “Journal of Medicinal Chemistry”

dAR-6–1 is a promising new treatment for hair loss that works better than minoxidil.

research Gpr54 deletion accelerates hair cycle and hair regeneration

1 citations , November 2024 in “EMBO Reports”

Deleting Gpr54 speeds up hair growth and regeneration.

research Collagen/Chitosan Gels Cross-Linked with Genipin for Wound Healing in Mice with Induced Diabetes

31 citations , December 2021 in “Materials”

The gels improved wound healing in diabetic mice but need human trials.

research Latanoprost-induced Skin Depigmentation

9 citations , November 2017 in “Journal of Glaucoma”

Latanoprost eye drops may cause skin depigmentation.

research New drugs under investigation for the treatment of alopecias

26 citations , January 2019 in “Expert Opinion on Investigational Drugs”

New treatments for hair loss show promise, but more research is needed to confirm their safety and effectiveness.

research Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

36 citations , March 2014 in “Annals of the Rheumatic Diseases”

Activating liver X receptors can reduce fibrosis by stopping certain immune cells from releasing harmful proteins.

research FOLLICULAR LIPOSOMAL DELIVERY SYSTEMS

55 citations , January 2002 in “Journal of liposome research”

New liposomal formulations may improve delivery of treatments to hair follicles, potentially helping with hair loss.

research TRAPPED IN THE HYPOGLYCEMIA LOOP

May 2025 in “Journal of the ASEAN Federation of Endocrine Societies”

Early advanced therapies are crucial for better survival in aggressive insulinoma cases.

research Effects of oxytocin receptor agonists on hair growth promotion

October 2024 in “Scientific Reports”

OXTR agonists may promote hair growth and be effective for treating hair loss.

research Comment on ‘Androgenetic alopecia is associated with increased scalp hardness’: role of phosphodiesterase inhibitors?

1 citations , April 2020 in “Journal of The European Academy of Dermatology and Venereology”

Drugs like PDEI may help hair disorders like AGA.

research Novel natural lipids based NLC containing finasteride improved androgenetic alopecia treatment in rats

October 2024 in “International Journal of Pharmaceutics”

Finasteride in lipid carriers improved hair growth in rats.

research TBG096 stimulates hair regeneration through IGF-1R-mediated angiogenesis

January 2026 in “Biochemical Pharmacology”

Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

research Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

1 citations , May 2022 in “Frontiers in Pharmacology”

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells

research Phloroglucinol Enhances Anagen Signaling and Alleviates H₂O₂-Induced Oxidative Stress in Human Dermal Papilla Cells

March 2024 in “Journal of Microbiology and Biotechnology”

Phloroglucinol may help improve hair loss by promoting hair growth and reducing oxidative stress.

research Actualités du SOPK

December 2006 in “Annales D Endocrinologie”

Estrogen-progestin contraception lowers ovarian, endometrial, and colon cancer risk but may raise breast and cervical cancer risk, helps with menstrual and acne issues, and new methods are as effective as pills. Metformin helps overweight women with PCOS and insulin resistance, and dopamine agonists treat prolactinomas.

research Lysophospholipid Mediators in Health and Disease

49 citations , November 2021 in “Annual review of pathology”

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.