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Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Vitisin A Outperforms Cyanidin-3-O-Glucoside in Triglyceride Reduction by Modulating Hepatic Lipogenesis and Fatty Acid β-Oxidation

5 citations , February 2025 in “International Journal of Molecular Sciences”

Vitisin A reduces triglycerides better than Cyanidin-3-O-glucoside.

research 11β-hydroxysteroid dehydrogenase type 1 inhibition attenuates the adverse effects of glucocorticoids on dermal papilla cells

September 2017

Blocking 11β-HSD1 reduces stress hormone damage in hair growth cells.

research Current and future perspectives on clinical management of classic 21-hydroxylase deficiency

January 2023 in “Endocrine Journal”

Treating classic 21-hydroxylase deficiency requires precise glucocorticoid dosing and attention to individual patient needs, with new treatments showing promise.

research Spectrophotometric method for the estimation of finasteride in tablets

4 citations , January 2002 in “Indian Journal of Pharmaceutical Sciences”

A new method accurately measures finasteride in tablets using color change and light absorption.

research Measurement of tamsulosin in human serum by liquid chromatography–tandem mass spectrometry

9 citations , April 2013 in “Journal of Chromatography B”

A reliable method was created to measure tamsulosin in human blood.

research Enhanced skin permeation of 5α-reductase inhibitors entrapped into surface-modified liquid crystalline nanoparticles

16 citations , August 2014 in “Archives of Pharmacal Research”

Special nanoparticles increased skin absorption of hair loss treatments with fewer side effects.

research Bioequivalence of two kinds of finasterides tablets in healthy volunteers

January 2004 in “Chinese Journal of New Drugs and Clinical Remedies”

The two finasteride tablet brands are bioequivalent.

research Are STK11 polymorphisms a predictor of the response to metformin in polycystic ovarian syndrome?

June 2022 in “Biomedical reports”

STK11 gene variations do not predict how well metformin will work for PCOS, but may affect hair loss and excess hair growth.

research Simultaneous HBV Reactivation and Hair Discoloration Under Secukinumab Treatment.

May 2025 in “PubMed”

Secukinumab treatment may cause HBV reactivation and hair discoloration.

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