research Defective trophoblast function in mice with a targeted mutation of Ets2
Ets2 gene is crucial for placental development in mice.
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research Guidelines for the management of alopecia areata
The 2003 guidelines suggest that while some treatments can regrow hair in alopecia areata, none alter the disease's progression, and wigs may be the best option for extensive hair loss.
research Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis
Certain mutations in a hair growth-related gene cause a type of genetic hair loss.
research Smad7-Induced β-Catenin Degradation Alters Epidermal Appendage Development
Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.
research Susceptibility variants for male-pattern baldness on chromosome 20p11
research KCNQ4 K+ channels tune mechanoreceptors for normal touch sensation in mouse and man
research Follicular miniaturization in female pattern hair loss: clinicopathological correlations
Hair loss severity relates to increased miniaturization in female pattern hair loss.
research Ichthyosis, Follicular Atrophoderma, and Hypotrichosis Caused by Mutations in ST14 Is Associated with Impaired Profilaggrin Processing
Mutations in the ST14 gene cause skin and hair issues by disrupting important protein processing.
research Advice on the safe introduction and continued use of isotretinoin in acne in the U.K. 2010
Isotretinoin is effective for severe acne but requires careful monitoring for side effects, especially in women who could become pregnant.
research Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment
Controlling inflammation can help heal diabetic foot ulcers.
research Hair Depigmentation Is a Biological Readout for Pharmacological Inhibition of KIT in Mice and Humans
Hair color loss can indicate the effectiveness of a drug targeting the KIT protein in mice and humans.
research Review article: dermatological complications of immunosuppressive and anti-TNF therapy in inflammatory bowel disease
Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.
research Receptor activator of NF-κB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit
RANK-RANKL signaling is essential for hair growth and skin health.
research Rosmarinus officinalis L. (Rosemary) Extracts Containing Carnosic Acid and Carnosol are Potent Quorum Sensing Inhibitors of Staphylococcus aureus Virulence
Rosemary extracts with carnosic acid and carnosol can reduce the harmfulness of Staphylococcus aureus without stopping its growth.
research Hair through the female life cycle
Women's hair generally gets thinner and less dense starting in their mid-thirties, with hair loss becoming more common as they age due to both genetics and environment.
research Alopecia areata and risk of atopic and autoimmune conditions: population-based cohort study
People with alopecia areata are more likely to have other immune-related conditions.
research Nobiletin-loaded composite penetration enhancer vesicles restore the normal miRNA expression and the chief defence antioxidant levels in skin cancer
Nobiletin-loaded vesicles effectively treat skin cancer by restoring normal miRNA and antioxidant levels.
research The effect of treatment with an LH-RH agonist (Buserelin) on gonadal activity growth and bone maturation in children with central precocious puberty
Buserelin safely and effectively suppresses early puberty, potentially improving final height.
research Raman spectroscopy and electronic microscopy structural studies of Caucasian and Afro human hair
Hair treatments cause significant structural changes, especially with excessive heat, regardless of ethnicity.
research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands
Blocking SCD1 in the skin with XEN103 shrinks sebaceous glands in mice.
research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but not for Maintenance of the Epidermal Stem Cell Compartment
Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.
research The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway
Quercitrin may help treat Alzheimer's by boosting brain cell signaling without causing tumors.
research The associated burden of mental health conditions in alopecia areata: a population‐based study in UK primary care*
People with alopecia areata have a higher risk of depression and anxiety, and often face unemployment and work absences.
research Dermatological practice and psychiatry
Many skin patients have mental health issues, so dermatologists should consider psychological care.
research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients
EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.
research Genetics of Wool and Cashmere Fibre: Progress, Challenges, and Future Research
More research is needed to improve wool and cashmere quality through genetics.
research Acoustic Fabrication of Collagen–Fibronectin Composite Gels Accelerates Microtissue Formation
Ultrasound helps create gels that speed up tissue formation.
research Combined drug triads for synergic neuroprotection in retinal degeneration
Using three different drugs together may better treat eye diseases like glaucoma and macular degeneration.
research Dermal TRPV1 innervations engage a macrophage- and fibroblast-containing pathway to activate hair growth in mice
Activating TRPV1 can boost hair growth by involving neurons, macrophages, and fibroblasts.
research Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis
People with alopecia areata are more likely to have anxiety and depression and a lower quality of life.