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Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.

Gender-affirming hormone therapy affects metabolism differently based on treatment type.

The discovery of 5α-reductase deficiency in guevedoces led to the development of important urologic medications.

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Low-dose DMSO may help treat castration-resistant prostate cancer by reducing key cancer cell receptors.

Treating early puberty with hormone therapy may increase the risk of polycystic ovary syndrome in adults.

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

Some hormone treatments might raise breast cancer risk, while others don't seem to.

Serenoa repens may help with prostate issues, but more research is needed to confirm its effectiveness.

Estrogen alone may effectively suppress testosterone in some transfeminine individuals.

Removing the ovarian tumor improved the woman's hormonal symptoms.

CB-03-04 shows promise as a treatment for prostate issues due to its strong anti-androgen effects.

The patient's high testosterone was reduced by a medication that suppresses gonadotropin.

Estrogen alone can lower testosterone in some transfeminine people.

Natesto nasal gel improves erectile function and mood in men with low testosterone within 30 days.

The patient was satisfied with hormone therapy, and her epilepsy remained stable.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

Bilateral salpingo-oophorectomy resolved hyperandrogenism in a postmenopausal woman with rare ovarian tumors.

New treatments for male hypogonadism are easier to use and target specific tissues to reduce side effects.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

RU 58841 may treat acne, hair loss, and excessive hair growth.